Pilavos 500mg Usarichpharm Treatment of Ec Mc, worm larvae moving under the skin (7 blisters x 4 tablets)

Thiabendazole not only prevents the production of eggs and larvae but also prevents the development of this egg or larvae when it is eliminated into feces.

Mechanism of action:

The mechanism of action of Thiabendazol on parasites is not known correctly but it can inhibit the reduction of fumarat, which is a specific enzyme.

The mechanism of destroying the Trichinella Spiralis larvae (these larvae have moved into the muscles) is unknown.

pharmacokinetics

absorption:

Thiabendazole is absorbed quite quickly and reaches the maximum concentration in the blood after taking the drug 1-2 hours.

Distribution:

In 48 hours, about 5% oral dose is found in feces and 90% in urine.

Metabolism:

Thiabendazole is converted almost completely into 5-hydroxy; In this form, it is present in the urine in the form of Glucuronid or Sulfate.

Era:

Most drugs are eliminated in the first 24 hours.

Caution when using

general

Thiabendazole is not suitable for the treatment of mixed mixture of ascaris, because it can make these worms move.

Some advice before treating worms should treat prior symptoms such as anemia, malnutrition, water deficiency.

Doctors must monitor patients with jaundice, reduce bile secretion, liver parenchyma damage.

Monitoring regularly in patients with liver and kidney failure.

In some very rare cases, liver damage may worsen and cannot reduce damage.

Because the drug contains lactose, it is not used for people with glucose deficiency - galactose.

Patient

Due to the side effects on the central nervous system, patients need to avoid neurological activities, requiring alertness.

The ability to cause cancer, gene mutations, reduce fertility:

Thiabendazol has been studied with short and long -term programs on animals at a dose greater than 15 times the normal dose of human use, so there is no effect of cancer.

Thiabendazole does not affect the disadvantage of fertility on mice at 2 '/2 times the normal dose of usage in humans or rats at the dose is equivalent to normal doses in humans.

Thiabendazole does not change gene in the test of bacterial genetically modified, micronucleus tests in Invivo and quantify the main intermediate substances in Invivo.

used in pediatrics:

Not used for pediatric patients weighing less than 13.60 kg.

Elderly patients:

There is no full study of the difference between the elderly (≥ 65 years old) and the young people in using Pilavos. However, when used for elderly people, they must be cautious, so starting from the lowest dose, regularly monitoring, liver, kidney function, heart, heart, monitor the diseases they are treating and using other drugs.

This drug is completely metabolized in the liver, and the metabolites are excreted by the kidneys so the risk of toxicity to the kidneys will be much greater in people with kidney failure. Because most of the older patients weaken the kidneys, when used for this object, they must choose the dose carefully and must monitor the kidney function regularly.

Signs to note and recommend:

Pilavos medicine is only used for patients who have known worms through testing, not used as prevention medicine.

Thiabendazole should not be used in the first regimen to treat entobiasis (needle worm disease), only for use in case patients can endure allergic reactions, or other treatments that fail.

When there is a sensitive (allergy), it must be stopped immediately.

The effect of the drug on the ability to drive and operate machinery

Because the drug causes dizziness and drowsiness, it is not used for drivers and operating machinery.

Use drugs for women during pregnancy and lactation

Pregnant women:

Research on reproduction as well as rabbits at rabbits at a dose greater than 15 times the normal dose for humans, on rats at a dose equivalent to humans and rats in the mouse at a dose greater than 2.5 times the normal dose for humans, no evidence is harmful to the fetus. In further research on mice, no defects when using Thiabendazol are in the form of a domestic phlegm with a large dose of 10 times the normal use of human use. But when using thiabendazol in the form of an epidemic in olive oil with the same dose, there is a defect: cleft palate of the palate, the optical shaft defect of the bone.

Because there are no adequate and controlled studies in pregnant women, this drug is not used for pregnant women.

breastfeeding women:

Do not know if the thiabendazole is excreted through breast milk or not, so it is not used for nursing mothers.

Drug interaction

thiabendazole competes with theophylin in the transformer position in the liver, so it increases the concentration of these compounds in serum up to the threshold of toxic dose.

Similarly, when used simultaneously with the derivatives of xanthin, it must be first and must monitor the concentration of drugs in the blood, or reduce the dose.

Using at the same time with other drugs must also be closely monitored.