Pimoint 20mg Romania treats rheumatoid arthritis (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Piroxicam

Ingredient

Composition information	Content
Piroxicam	20mg

Uses

indications

Pimoint drugs are indicated in some diseases that require anti -inflammatory and/or analgesic diseases:

rheumatoid arthritis and osteoarthritis, osteoarthritis.

Againon inflammation, acute musculoskeletal disease and sports injury.

Sutta and pain after surgery.

Acute gout.

Pharmacokinus

Piroxicam is an nonsteroidal anti -inflammatory drug, of the Oxicam group, which has anti -inflammatory, analgesic and antipyretic effects. The mechanism of action of the drug is not clear. However, the general mechanism for the above effects may be due to the inhibition of prostaglandin synthetase and thus prevents the formation of prostaglandin, thromboxan, and other products of cyclooxygenase enzymes.

Piroxicam can also inhibit the activation of neutral polygon leukemia, even if there are products of cyclooxygenase. Therefore, anti -inflammatory effects also include proteoglycanase and collagenase inhibition in cartilage. Piroxicam is not impacted by online stimulation of Yen - adrenal. Piroxicam also inhibits platelet capacitors.

Because Piroxicam inhibits the synthesis of prostaglandin in the kidney, it reduces blood flow to the kidneys. This is especially important for patients with kidney failure, heart failure and liver failure, and important for patients who have a change in plasma volume. After that, decreased to form prostaglandin in the kidneys can lead to acute renal failure, water retention and acute heart failure.

Dynamic pharmacokinetics

Piroxicam is well absorbed through the gastrointestinal tract. Peak concentration in plasma appears from 3-5 hours after taking the drug. Food and anti -acid drugs do not change the speed and level of drug absorption. Because Piroxicam has a liver -intestinal cycle and has a lot of difference in absorption among patients, half -life eliminates the drug in plasma varies from 20 to 70 hours. This can explain why the effects of the drug are so different from patients, when using the same dose. It also means that the stable state of the drug is achieved after very different treatment, from 4 to 13 days.

The drug is very strong with plasma proteins (about 99%). The distribution volume is approximately 120 ml/kg. The concentration of drugs in plasma and in the epidemic is approximately equal when the drug state is stable (that is, after 7-12 days). Under 5% of urine excreted drugs in the form of unchanged. The main metabolism of the drug is hydroxyl - chemical pyridine, followed by glucuronic acid, then this complex is excreted in urine.

Before taking Pimoint 20mg Romania treats rheumatoid arthritis (10 blisters x 10 tablets)

How to use

oral medication.

Dosage

Adults

Use 20 mg, once a day. Some people may respond to a dose of 10 mg daily, others may have to use 30 mg daily, drink once or divide 2 times a day. Because the half -life of the drug is prolonged, the drug concentration has not reached a stable level within 7-10 days, the response to the drug increases slowly over a few weeks.

Piroxicam is also used in the treatment of acute gout at a dose of 40 mg daily in 5-7 days.

Children

Do not use drugs for children. However, Piroxicam can also be used for children 6 years of age and older with rheumatoid arthritis.

Usable oral dose: 5 mg/day for children weighing less than 15 kg, 10 mg/day for children weighing 16-25 kg, 15 mg/day for children to weigh 26 - 45 kg, and 20 mg/day for children to weigh 46 kg or more.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? Currently, due to the lack of experience in overdose, it is impossible to know the effectiveness and recommendations on specific detoxification effectiveness. However, gastric and supportive treatment measures should be applied. Drinking activated carbon can reduce the absorption and reabsorption of Piroxicam effectively, and thus reduces the remaining drug.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using pimoint drugs, you may experience unwanted effects (ADR).

Over 15% of Piroxicam users have some unwanted reactions, most of the digestive tract but many reactions do not hinder the treatment. About 5% must stop treatment.

Common, ADR> 1/100

Digestive: stomatitis, anorexia, epigastric pain, nausea, constipation, abdominal pain, diarrhea, indigestion.

Hematology: Hematitis and hematocrite, anemia, leukopenia, Eosin hypernagus. skin: itching, rash. nerve: dizziness, dizziness, drowsiness.

urinary tract: increased urea and blood creatinin.

Systemic: headache, discomfort.

Tinneton: tinnitus.

Cardiovascular, respiratory: edema.

Uncommon, 1/1000

Gastrointestinal: abnormal liver function, jaundice, hepatitis, gastrointestinal bleeding, perforation and ulcers, dry mouth.

Hematology: thrombocytopenia, hemorrhagic dots, bruising, myeloma.

Skin: Sweating, Red rash, Stevens - Johnson syndrome.

nerve: depression, insomnia, restlessness, stimulation.

urinary tract: Hematuria, protein - urinary, interstitial nephritis, nephrotic syndrome. Systemic: Fever, symptoms like influenza.

The senses: swelling of the eyes, blurred vision, irritant eyes.

Cardiovascular, respiratory: Hypertension, congestive heart failure.

Rare, ADR

Digestive: pancreatitis.

Skin: thin pepper, hair loss.

Neither nervous: restlessness, restless sitting, hallucinations, changing temperament, composition.

Urinary tract: difficult urine. Body: Weakness.

Sensory: Temporary hearing.

Hematology: Hematopathy.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Pimoint drugs in the following cases:

Hypersensitivity to piroxicam.

Stomach ulcer, acute duodenum ulcer.

History of bronchospasm, asthma, nasal polyps and quincke edema or jute due to Aspirin, or another nonsteroidal anti -inflammatory drug.

cirrhosis.

Severe heart failure.

People with many risks of bleeding.

Renal failure people with glomerular filtration level below 30 ml/min.

Be cautious when using

Use cautiously in the following cases: Elderly. Bleeding disorders, cardiovascular disease, a history of stomach -duodenal ulcer, liver failure or renal failure. People who are taking diuretics.

The ability to drive and operate machinery

Patients should be warned that it may occur dizzy, drowsiness and blurred vision.

Pregnancy

Like other Prostaglandin inhibitors and release, Piroxicam causes the risk of lung increased lung pressure in infants, due to arterioscleric closing if these drugs are used in the last 3 months of pregnancy. Piroxicam also inhibits labor, prolongs pregnancy, and is toxic to the gastrointestinal tract in pregnant women. Do not use piroxicam for pregnant women in the last 3 months or near labor.

Breastfeeding period

Piroxicam excreted into breast milk. Not determined the safety of the drug used for mothers during breastfeeding.

Drug interaction

When using piroxicam simultaneously with cumarin anticoagulant drugs and high protein -linked drugs, physicians need to monitor patients closely to adjust the dose of the drugs accordingly. Because of the high protein bond, Piroxicam can push other drugs from plasma proteins.

Do not treat the drug simultaneously with aspirin, as this will lower the concentration in the blood of Piroxicam (about 80% when treated with 3.9 g of aspirin). Besides, it is not better than when only treated with aspirin, but also increases unwanted effects.

When treating drugs simultaneously with lithium will increase lithium toxicity due to increasing lithium concentration in plasma. Therefore, it is necessary to closely monitor the concentration of lithium in plasma.

Use piroxicam simultaneously with antacidants that do not affect the concentration of piroxicam in plasma.

Storage

Keep in the original packaging, the temperature does not exceed 30 ° C.

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