PINCLOS 75mg Incepta tablets reduce events due to atherosclerosis, myocardial infarction (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Clopidogrel

Ingredient

Composition information	Content
Clopidogrel	75mg

Uses

indications

Pinclos drugs are indicated in the following cases:

Treatment of reduced events caused by atherosclerosis (myocardial infarction, stroke and stroke) in patients with a history of atherosclerosis manifested by ischemic stroke (from 7 days to less than 6 months), myocardial infarction (from a few days to less than 35 days) or peripheral artery disease. myocardial infarction does not have Q wave), used in combination with acetylsalicylic acid.

Clopidogrel has a selective inhibitory effect on adenosin diphosphate (ADP) on platelet receptors and consequently the intermediate activity ADP of Glycoprotein GPIIB/IIIA complex, thus inhibits the collection of platelets. Clopidogrel also inhibits platelet aggregation due to the amplification of platelet activation from ADP release.

Pharmacokinetics

absorption

After drinking, Clopidogrel is absorbed quickly but not completely, at least absorbing at least 50%. Food does not affect the bioavailability of clopidogrel.

Distribution

clopidogrel and carboxylic acid derivative high with protein (98% with clopidogrel and 94% with metabolites).

Metabolism

Clopidogrel metabolizes mainly in the liver, the main metabolites are inactive carboxylic acid derivatives. This metabolite accounts for 85% of the drug in plasma and reaches the peak concentration in plasma (about 3 mg/l after taking a dose of 75 mg repeated) after taking 1 hour.

Elimination

Clopidogrel and metabolites are excreted mainly in urine and feces; About 50% of oral doses are excreted in the urine and about 46% excreted in stool after 5 days of taking the drug. The half -life of the drug is 8 hours.

Before taking PINCLOS 75mg Incepta tablets reduce events due to atherosclerosis, myocardial infarction (3 blisters x 10 tablets)

How to use

pinclos is an oral medication according to the instructions of the treating doctor.

Dosage

Adults

The only dose of 75 mg/day, can be used or not at the same meal.

In patients with acute coronary syndrome without stir segment (unstable angina or myocardial infarction without Q): should start treatment at a dose of 300 mg of clopidogrel on the first day, then continue the dose of 75 mg/day (combined with acetylsalicylic acid 75 - 325 mg/day) in the following days.

Elderly or patients with renal failure

No dose adjustment.

children and young people

There is no data on the safety and effectiveness of the drug for patients under 18 years old.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when using overdose? Bleeding time increases to 1.7 times equivalent to Clopidogrel dose of 75 mg/day.

There is no drug that detoxifies the pharmacological activity of clopidogrel. Platelets can limit the effect of clopidogrel.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using PincoS, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Bleeding: stomach bleeding, hemorrhage, bruising, hematoma and nosebleeds, hematoma, bleeding and bleeding in the eye (mainly conjunctiva).

nerve: such as headache, dizziness, loss of balance and paresthesia. stomach - intestines: abdominal pain, anorexia, gastritis and constipation.

Skin and subcutaneous tissue: itchy. liver: liver and bile disorders.

Uncommon, 1/1000

Hematology: severe neutropenia, severe platelets.

digestive: constipation, toothache, vomiting, flatulence, and gastritis.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

PINCLOS drugs contraindicated in the following cases:

Too hypersensitivity to clopidogrel bisulfate or any ingredient of the drug.

Severe liver failure.

There is pathological bleeding such as digestive ulcers or bleeding in the brain.

Pregnant or breastfeeding women.

Children under the age of 18.

Be cautious when used

In patients with acute myocardial infarction, do not start treating clopidogrel for the first few days after myocardial infarction.

Like other anti -platelets, Clopidogrel should be used with patients with increased risk of bleeding due to trauma, surgery or other pathological conditions. Clopidogrel should stop using Clopidogrel 7 days before surgery to avoid platelet resistance.

Clopidogrel extends the bleeding time and should be used carefully with patients who are likely to bleed (especially the stomach and intraocularity).

Patients should be known when using clopidogrel longer than usual, they must stop using when bleeding appears and should notify abnormal bleeding for a doctor. Patients should notify the doctor and dentist to use Clopidogrel before surgery and before taking any new drug.

Not much experience using clopidogrel in medium -sized liver failure patients who may have bleeding organs. Be cautious when using clopidogrel for these patients.

Do not use clopidogrel with warfarin as it can increase the level of bleeding.

Because of the ability to increase the risk of bleeding, caution should be used when combined with clopidogrel with acetylsalicylic acid, nonsteroidal anti -inflammatory drugs, heparin, or thrombolytic drugs.

The ability to drive and operate machinery

There is no relevant report, but Clopidogrel can cause headaches, dizziness, and loss of balance. Therefore should be cautious when driving or operating machinery.

Pregnancy

Studies of reproductive processes in mice and rabbits found that there is no sign of weakening fertility or miscarriage caused by clopidogrel. However, there are no adequate and controlled studies on pregnant women. Therefore, do not use clopidogrel during pregnancy.

The period of breastfeeding

Because the drug has not been fully studied in breastfed babies, do not use clopidogrel for breastfeeding women.

Drug interaction

warfarin: Do not use clopidogrel with warfarin as it can increase the level of bleeding.

Acetylsalicylic acid:

does not change the ability to inhibit platelet training due to the ADP of clopidogrel, but clopidogrel increases the effectiveness of acetylsalicylic acid on the platelet aggregation due to collagen. Clopidogrel. Therefore, be careful when used in combination.

Heparin: Pharmacological interaction between clopidogrel and heparin is possible, increasing the risk of bleeding. Therefore, be careful when used in combination.

Non -steroid anti -inflammatory drugs (NSAID): Be cautious when used in combination with clopidogrel with NSAIDs due to the phenomenon of hidden gastric bleeding.

Other combination of treatment: There is no clinical interaction with pharmacological significance when used in combination with clopidogrel with Atenolol, Nifedipin, or both Atenolol and Nifedipin.

pharmacokinetics of Digoxin or theophyllin is not changed when combined with clopidogrel.

Stomach antacids do not change the absorption time of clopidogrel.

Phenytoin and Tolbutamid can be combined safely with clopidogrel.

antifungal drugs (ketoconawl, fluconazole, voriconazole): avoid simultaneous use of clopidogrel with antifungal drugs.

bupropion:

Clopidogrel may increase blood concentration and increase the effects of bupropion, thus increasing the side effects of bupropion such as agitation, dry mouth, insomnia, headache/migraine, nausea/vomiting, constipation, tremor.

Statin:

Statin drugs can inhibit the activity of CYP enzymes, slow down the metabolism of clopidogrel into active metabolites, thus reducing or losing the effect of the drug.

Cyclosporin: Clopidogrel should be used cautiously when used simultaneously with cyclosporin A in kidney transplantation because the risk of drug interaction can reduce cyclosporin levels and cause acute transplantation.

Storage

Store in a cool dry place, below 30 ° C, avoid light.

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