Piracetam-Egis 1200mg medicine for physical mental syndrome, muscle vibration (20 tablets)

Dosage form Box of 20 capsules
Specifications Piracetam

Ingredient

Composition information	Content
Piracetam	1200mg

Uses

indications

Piracetam Egis 1200mg pills are indicated in the following cases:

Treatment of symptoms of physical mental syndrome (memory disorders, lack of attention, reduced activity). Simply use or combination of drugs. A intellectual orientation has a complex mechanism of action. Piracetam works by increasing nucleotid metabolism in nerve cells, increasing glucose and oxygen consumption in the brain and increasing acetylcholine and dopamine details in nerve cells. Piracetam level is attached to the dual layer of phospholipids of the cell membrane depending on the dosage, the drug restores the integrity of the structure, which is thought to increase the liquid and function of the membranes.

Pharmacokinetics

absorption

After drinking, Piracetam is quickly absorbed in the formless form. Birth is almost 100%. Use at the same time with food does not affect the absorption, but the value of CMAX decreases and TMAX increases.

Distribution

Peak concentration in plasma is achieved after taking 30-60 minutes and in cerebrospinal fluid for 2 - 8 hours.

Metabolism

The semi -exhaust time of Piracetam is 4-5 hours in plasma and 6-8 hours in cerebrospinal fluid. The ratio of cohesion to plasma protein is 15%. Piracetam focuses on cerebral cortex, cerebellum, double, hippocampus, external pillows and vein puppets.

Elimination

The drug is discharged in the urine in the form of unchanged. After single dose, 90 - 100% of the drug is discharged within 24 - 30 hours. Piracetam passes the blood -brain barrier through the placenta (the concentration of the fetus is 70-90% of the drug concentration in the mother) and is secreted into breast milk. Piracetam can be separated (the cup efficiency is 50 - 60%).

Before taking Piracetam-Egis 1200mg medicine for physical mental syndrome, muscle vibration (20 tablets)

How to use

take oral medication, can be used with or not with food. Taking medicine with water, daily dose can be divided into 2 to 4 times.

Dosage

Adults

Dosage must be determined for each case based on the severity of the disease and clinical response. The normal starting dose for adults is 2400 mg daily, maintenance dose is 1200 - 2400 mg daily. The maximum daily dose is 4800 mg.

Treatment time must be determined based on the patient's clinical condition.

In chronic diseases, usually treated for about 6 - 12 weeks for maximum effectiveness. After three months of treatment, the use of drugs must be reviewed and decided to see if it continues. If you have to treat longer, you should reduce the dose or stop the drug completely in a period of 6 months.

Treatment of symptoms of physical mental syndrome: 2.4 - 4.8 g/day divided into two to three times.

Muscle vibration due to brain warts: The daily starting dose is 7.2 g; When necessary, it can increase 4.8 g each time 3-4 days to 24 g per day, divided into two to three times. Other drugs used to treat muscle vibration due to cerebral cortex should be maintained at normal doses, then depending on the clinical improvement that can reduce the dose of these drugs.

When treated, continue using piracetam if there are still symptoms of the disease, in acute stage patients, the condition can be improved over time and need to be achieved every 6 months to be able to reduce or stop treating drugs. This should be done by gradually reducing the dose of 1.2 g after every 2 days (every 3-4 days in Lance and Adam syndrome - to avoid unexpected recurrence or convulsions due to quitting drugs).

Dizziness: Daily recommendations are 2.4 - 4.8 g divided into two to three times.

Dosage for children

Children read difficult: Children 8 years of age and older: Daily recommendations are 3.2 g divided into two times, in collaboration with the method of teaching linguistic disability.

Dosage for the elderly

Should adjust the dose for the elderly with impaired renal function. Used for prolonged treatment for the elderly, it is necessary to periodically evaluate creatinine clearance to adjust the dose when necessary.

Dosage for patients with impaired renal function

Daily dose must be determined for each patient depending on the condition of the kidney function. Refer to the following guide and adjust the appropriate dose. To determine the following dose, it is necessary to estimate the patient's creatinine clearance according to ml/min.

group

Creatinine clearance

(ml/minute)

Dosage Time. At the end

No dose adjustment for patients only suffer from liver failure. Dosage adjustment for patients with liver failure with renal failure.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Symptoms

The highest piracetam overdose dose is reported as 75 g. Abdominal pain and hemorrhagic diarrhea have occurred, possibly due to the very high sorbitol content in the product formula. No other unwanted effects have been recorded when using Piracetam overdose.

Overdose

In case of acute overdose, gastric lavage or vomiting. There is no specific antidote for Piracetam. Overdose treatment by treating symptoms and can remove Piracetam by blood decentralization with an efficiency of separating 50 - 60%.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Piracetam Egis 1200 mg you may experience unwanted effects (ADR).

Classification of agency systems Common rarely encounter

Bleeding disorders. Enlightenment. face. jute. guide how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Piracetam Egis 1200 mg contraindicated in the following cases:

Hypersensitivity to piracetam, with other pyrolidon derivatives, or any other ingredients of the drug.

cerebral hemorrhage.

End phase renal failure.

Huntington dance.

Precautions when using

affect platelet collection

Because Piracetam has the effect of inhibiting platelet aggregation (see Pharmacological section), it is necessary to be cautious when used for patients with severe bleeding, patients at risk of bleeding such as gastrointestinal ulcers, patients with hemodynamic disorders, patients with a history of cerebral hemorrhage, patients undergoing large surgery including dental surgery, patients using anti -coagulopathy drugs including acidylsalys acidlsalylicylitis Low.

Renal function impairment

Piracetam is eliminated through the kidneys and therefore be cautious when taking this drug for patients with renal failure.

Take medicine for the elderly

When taking prolonged drugs for the elderly, they need to periodically evaluate creatinine clearance to adjust the dose accordingly (see the dose and usage section).

Stop medicine

Avoid sudden stopping of medication in patients with muscle vibration due to cerebral cortex because it can cause recurrent convulsions or convulsions by quitting.

The ability to drive and operate machinery

With unwanted effects to observe, Piracetam can affect the ability to drive and operate machinery. Therefore, it is necessary to be cautious and must be decided by a doctor.

Pregnancy

There is no adequate data on the use of piracetam for pregnant women. Animal studies do not show direct or indirect harm to pregnancy, fetal development, affecting the birth or postpartum development.

Piracetam passes through the placenta fence. The concentration of drugs in infants is approximately 70 - 90% of the drug concentration in the mother's body. Piracetam should not be used for pregnant women unless it is really necessary, when the benefits of treatment greater than the risk may occur and the clinical condition of the mother needed to be treated with piracetam.

The period of breastfeeding

piracetam is secreted into the mother's milk. Therefore, piracetam should therefore be breastfeeding or should stop breastfeeding when using piracetam. It is necessary to consider stopping breastfeeding or stopping treatment with Piracetam based on the evaluation of the benefits of breastfeeding on the baby compared to the benefits of the mother's treatment.

Drug interaction

Pharmacokinetic interactions: less likely to interact with drugs, leading to piracetam pharmacokinetics changes because about 90% of piracetam dose is eliminated in urine in unchanged form.

On in vitro, Piracetam concentration 142, 426 and 1422 μg/ml does not inhibit cytochrome P450 liver enzymes in humans (CYP 1A2, 2A6, 2B6, 2C8, 2C9, 2C19, 206, 2E1 and 4A9/11).

At concentration of 1422 μg/ml, observing the mild inhibition of CYP 2A6 (21%) and 3A4/5 (11%). However, the ki values indicate the inhibition of these 2 cyp liver enzymes can increase at piracetam concentration in excess of 1422 μg/ml. Therefore there is no interaction in metabolism between piracetam and other drugs.

thyroid hormone

Confusion, stimulation, sleep disorders may occur when using simultaneously piracetam with thyroid hormone (T3 + T4).

acenocoumarol

In a single blind study conducted in patients with severe recurrent vein thrombosis, using piracetam at a dose of 9.6 g/day does not affect the dose of acenocoumarol needed to achieve Inr 2.5 to 3.5 but compared with the effect of monopoly acenocoumarol, the addition of piracetam 9.6 g/day significantly reduces the collection of plasma Fibrinogen and the elements Von Willebrand (VIII: C; VIII: VW: Ag; VIII: VW: RCO), Visuality of plasma and total blood.

Anti -epileptic drugs

Dosage 20 g of Piracetam per day for 4 weeks does not change the highest concentration and the lowest concentration of anti -epileptic drugs (carbamazepin, phenytoin, phenobarbiton, valprooat) in epilepsy patients are taking stable dose.

alcohol

Take the same dose of 1.6 g of piracetam with alcohol that does not affect the plasma concentration of both substances.

Storage

Store drugs at temperatures below 30 ° C.

Other drugs

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