Pirolam Medana Skin Gel for Fungal Diseases, Scalp Fungal, Foot Fungus (20g)

Dosage form Gel
Specifications Tube
Ingredient Ciclopirox lamin

Ingredient

Thành phần cho 1g

Composition information	Content
Ciclopirox lamin	10mg

Uses

Indications

Piram 20g pills are indicated in the following cases:

Treatment of skin fungal disease , scalp fungus, leg fungus, nail mushrooms and thigh skin fungus caused by:

trichophyton rugum;

trichphyton mentagrophytes; tropicalis;

Candida Krusei;

Pharmacokology

ciclopirox , a pyridon derivative and a broad -spectral synthetic antifungal. Ciclopirox has the effect of killing fungi and spores. This effect is related to the inhibition of absorption (Leucin) and preventing the accumulation of cells in cells that play an important role in the metabolism and growth of mushroom cells, including inhibition of calcium and potassium ions into the fungal cells. Ciclopirox creates a chelat complex with multi -chemotherapy cation (Fe3+, AI3+) and inhibits some metal -dependent enzymes, which are involved in mushroom cell respiration.

Ciclopirox accumulates in cells and mounted, sometimes not recovered, with many different organizations such as endoplasmic grid, ribosom, mitochondrial and cell wall. Ciclopirox penetrates the skin through the epidermis, hair follicles and oily glands.

Compared to other antifungal drugs, Ciclopirox has a different chemical structure, broad spectrum, stronger anti -inflammatory effects and better penetration into the keratin layer. The broad effect of the drug includes skin fungus, yeast, mold and mixed mushrooms.

Ciclopirox's anti -inflammatory effects are due to inhibition of cyclooxygenase and lipoxygenase and stronger than ketoconazole, fluconazole, miconazole and naphtyllin.

ciclopirox works on all skin mushrooms, yeast, mold and mixed mushrooms. In addition, Ciclopirox acts on Gram -positive bacteria, gram negative and inhibited Mycoplasma, Trichomonas, Chlamydia regardless of pH.

pharmacokinetics

ciclopirox penetrates into hair, hair follicles through epidermis and sebaceous glands. A part of Ciclopirox remains in the epidermis's horny film.

Research on permeability shows that 0.8 - 1.6% Ciclopirox can be found in the horn film 1.5 to 6 hours after applying the drug.

Ciclopirox concentration in the skin is 10 to 15 times higher than the minimum inhibitory concentration of mushroom growth.

ciclopirox and metabolites are quickly excreted through the kidneys. After applying the medication on the spot, most of the absorption dose will eliminate through the kidney within 8 to 12 hours. Two days after applying the drug, only 0.01% of the dose detected in the urine.

Before taking Pirolam Medana Skin Gel for Fungal Diseases, Scalp Fungal, Foot Fungus (20g)

How to use

Piram 20g medicine is an external medicine.

Dosage

drugs for adults and children over 6 years old.

Apply Pirolam 20g 2 times daily to the contaminated skin, gently rub or let the gel layer naturally dry. Continue to take the drug until the symptoms are over. Optimal treatment time with ciclopirox olamin up to 3 weeks.

In order to prevent recurrence, it is advisable to continue treating for 10 days after the lesions have recovered. Notice your doctor if the disease does not improve after 4 weeks.

Do not use fabric or stickers, except for treating nail mushrooms can be used to cover the contaminated area.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose? Sometimes skin irritation can be irritated.

What to do when forgetting a dose? The next dose is still used normally according to the planned plan. Do not offset the dose by applying two doses together.

Side Effects

When using piram 20g pills , you may experience unwanted effects (ADR).

Unwanted effects include burns, skin irritation, irritation, itching, and observation edema in some patients (1 - 4%).

Instructions on how to handle ADR

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Piram 20g contraindicated in the following cases:

Hypersensitivity to Ciclopirox or any excipients of the drug.

Do not use Pirolam 20g for children under 6 years old. There is no full study of Ciclopirox's safety assessment in children.

Do not use this medication for mushrooms in the eyes or tissues around the eyes.

Be cautious when using

in pregnant women and nursing women, using only ciclopirox in necessary cases. Do not scratch itching and scratch the mushroom lesions.

Avoid contacting the eye.

Do not use Pirolam 20g in the vagina.

Avoid wearing moisture and hot shoes and shoes. After washing or bathing, wipe the infected areas thoroughly.

Daily changing clothes, towels, gauze (nail fungus) if exposed to the infected area. Washing at 90 ° C (Should use one -time shower towels).

Propylene alcohol may cause skin irritation.

Methyl parahydroxybenzoate drugs, propyl parahydroxybenzoate propyl can cause skin allergies (can cause late allergies) and sometimes cause bronchospasm.

The ability to drive and operate machinery

Piram 20g leather mixture does not affect the ability to drive or operate machinery.

Pregnancy

There is no appropriate research and good control in pregnant women. Therefore, only the use of Ciclopirox during pregnancy if the benefits overcome the risk to the fetus.

Research on post -oral medication development is done in mice, missed rats, rabbits and monkeys. Ciclopirox or Ciclopirox Olamin is taken orally for these objects during the development of the fetal organ. Do not record any toxicity or cause over -fetus at high doses of Ciclopirox 77, 125, 80 and 38.5mg/kg/day respectively on mice, missed rats, rabbits and monkeys (approximately 11, 37, 51 and 24 times the maximum recommended dose for people calculated by the ratio of body surface area).

Fetal skin development studies are conducted in missed mice and rabbits use Ciclopirox olamin dissolved in PEG 400. Ciclopirox olamin is applied on the spot during the formation of fetus organs. Do not record any of the toxicity or over -fetal causes at high doses of Ciclopirox 92mg/kg/day and 77mg/kg/day on the corresponding mouse and rabbits (approximately 27 and 49 Maximum recommendations for people to calculate by the ratio of body surface area).

Breastfeeding period

It is unclear whether the drug is except for breast milk or not. Due to many drugs into breast milk, it should be cautious when using Ciclopirox mixture in breastfeeding women.

Drug interaction

There is no interaction when applying the drug simultaneously with 1%hydrocortison cream. Ciclopirox works with ITRACANAZOL or Terbinafin, so it is necessary to reduce the dose of simultaneous use.

Storage

Store in cool dry places below 30 ° C, avoid light.

To be out of reach of children.

Other drugs

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