Pit-Stat 2mg drugs add diet to reduce total cholesterol (1 blister x 10 tablets)

Dosage form Box of 1 blister x 10 tablets
Specifications Pitavastatin

Ingredient

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Composition information	Content
Pitavastatin	2mg

Uses

Indications

Pit-staules indicated treatment in the following cases:

Reducing total cholesterol (TC) and LDL-C, in adults, adolescents and children 6 years of age and older suffering from primary blood cholesterol, including heterozygic blood cholesterol (genetic) and mixed blood lipid disorders, patients when diet and combination of exercise can not lower cholesterol levels.

Pharmacokology

pitavastatin is a competitive inhibitor and selective HMG-COA reducing enzyme, a decision of the level of cholesterol synthesis in the liver and by increasing the number of LDL receptors in the liver on the surface cell to increase the process of LDL recovery and metabolism, reducing the total concentration of cholesterol (TC) and TC) LDL-Cholesterol (LDL-C) in the blood.

Its prolonged liver cholesterol synthesis reduces VLDL secretion (lipoprotein very low density) into the blood, reducing the concentration of triglyceride (TG) in plasma.

Pharmacological effects: Pit-Stat Tablet IMG reduces LDL-C, total cholesterol, triglycerides and increases HDL cholesterol (HDL-C). Pit-Star Tablet IMG reduces APO-B and creates increasing variables in APO-A1. It also reduces Non-HDL-C and reduces cholestero/HDL-C, APO-B/APO-A1 ratio.

pharmacokinetic

absorption

Pitavastatin is quickly absorbed by the above gastrointestinal tract and the peak concentration of plasma is achieved within an hour after drinking. The absorption is not affected by food. The drug does not
changes through the circulatory cycle and is well absorbed from white and ileum. Pitavastatin's absolute bioavailability is 51%.

Distribution

Pitavastatin binds more than 99% of human plasma proteins, mainly with albumin and alpha-acid glycoprotein, and the average distribution integral is about 133 L. Pitavastatin is not a chop-glycoprotein.

Metabolism

pitavastatin is mainly in a constant form in plasma. The main metabolite is the inactive lactone formed through a Glucuronide Pitavastatin in the form of ester by UDP Glucuronosyltransferase (UGT1A3 and 2B7). In In vitro studies, the use of 13 cytochromep450 (CYP) isomers of humans, indicating that the metabolism of pitavastatin because CYP is dark
; CYP2C9 (and to a lower level is responsible for the metabolism of pitavastatin into small metabolites.

Elimination

pitavastatin is unchanged to quickly excreted by the liver in the bile, but it must undergo the intestinal circulation, contributing to its time. Less than 5% pitavastatin is eliminated in the urine.

Half lifetime of plasma elimination ranges from 5.7 hours (single dose) to 8.9 hours (stable state and medium oral clearance is 43.4 hours after the single dose.

Before taking Pit-Stat 2mg drugs add diet to reduce total cholesterol (1 blister x 10 tablets)

How to use

The drug should only be used for oral and should swallow the whole tablet. Can be taken at any time of the day, together with food or not. However, patients should take the drug at the same time of the day.

M more effective statin therapy in the evening due to the biological rhythm of lipid metabolism.

If children or teenagers cannot swallow the pills, when necessary, the pill can be dispersed in a cup of water and drink immediately. To ensure the exact dosage, rinse with a little water and drink immediately. The drug is not dispersed in acidic or milk juice.

Dosage

Patients should have a diet to reduce cholesterol before treatment. It is important that all patients need to continue controlling the diet during treatment. The normal starting dose is pitavastatin, once a day. Dosage adjustment should be done in a period of 4 weeks or more. Should be individualized at LDL-C level, the goal of treatment and response of the patient.

Maximum daily dose is 4 mg.

Elderly: No need to adjust the dose in patients over 70 years old.

Pediatric patients:

Children and teenagers aged 6 years and older: The use of 1mg Pi-Stat Tablet in children should only be done by doctors who have experience in treating blood lipids and treatment process should be monitored regularly.

In children and teenagers hyperlested heterozygous family blood, the starting dose is usually 1 mg, once a day. Dosage adjustment should be done in a period of 4 weeks or more.

In children from 6 to 9 years old, the maximum daily dose is 2mg. In children 10 years of age and older, the maximum daily dose is 4 mg.

In children younger than 6 years old: Safe and effective of Pit-Sat Tablet 1mg in children under 6 years old has not been set up and has not even data.

Patients with impaired renal function. There is no need to adjust the dose in patients with mild renal function, but should be used carefully. Data at a dose of 4 mg is limited to all levels of renal function. Therefore, only 4 mg dose with strict supervision after determining the dose. For patients with severe renal failure, the 4 mg dose is not recommended.

Patients with liver function are impaired from mild to medium: The dose of 4 mg is not recommended for patients with mild to medium liver failure. The maximum dose for 1 day is 2 mg with close monitoring.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? Patients should be treated symptoms and supportive measures set up as required. Need to monitor liver function and concentration CK.

Hemodialysis is not beneficial.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

Notify the physician the unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Pit-stat drugs are contraindicated in the following cases:

Patients with hypersensitivity to the ingredients of the drug.

Precautions when using

No data.

Medicinal interaction

Medicinal interaction may affect the activity of the drug or cause side effects.

Patients should notify the doctor or pharmacist a list of the drugs and functional foods you are using. Do not use or increase or decrease the dose of the drug without the guidance of a doctor.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

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