Pizar-3 Davipharm tablets treat infections caused by parasites, worms (1 blister x 4 tablets)

Dosage form Box of 1 blister x 4 tablets
Specifications Ivermectin

Ingredient

Composition information	Content
Ivermectin	3mg

Uses

indications

Pizar 3 drugs are indicated in the following cases:

Treatment worms only onchocerca, although the drug is effective in the treatment of worms including racemia in the intestine due to Strongyloides Stercoralis. The role of Ivermectin in worms only in the lymphatic system has not been carefully studied.

Pharmacology

Ivermectin is the semi -synthetic substance of one of Avermectin, a group of large lacton structons, isolated from the fermentation of Streptomyces Avermitilis. Ivermectin has a broad spectrum on roundworms and secretions of cattle, thus being used in veterinary. The drug was first used for humans in 1981. Ivermectin was effective on a variety of round worms such as races, hair worms, needle worms, roundworms, hookworms and worms Wuchereria bancrofti. However, the drug does not work on liver fluke and tapeworms.

Currently, Ivermectin is a chosen drug to treat worms only onchocerca Volvulus and is a worm larvae that is only very strong, but has little effect on mature parasites. After drinking for 2-3 days, the worm larvae only go away quickly; The larvae in the cornea and eye room are slower.

The effect of the drug may last up to 12 months. One month after use, the larvae at the uterus only mature unable to escape, and then degenerated and eliminated. The effect of prolonged larvae is very helpful in preventing the spread of the disease.

already know quite well the mechanism of action of Ivermectin on worms only onchocerca. The drug causes direct toxic effects, immobile and eliminating larvae through lymphatic lymphatic. Ivermectin stimulates the secretion of neurotransmitters is Gama-Amino Butyric Acid (GABA). In sensitive worms, the drug affects by enhancing the release of gaba after the nerve joints that make the worm paralyzed.

Ivermectin does not easily join the central nervous system of mammals. Therefore, it does not affect the nerve conduction dependent of these species.

Dynamic pharmacokinetics

unknown the absolute biological use of the drug after taken. In general, there is no difference in the peak concentration in the plasma between the tablet form and the capsule form (46 compared to 50 micrograms/ l). However, when using Ivermectin in a solution of alcohol water, the peak concentration doubled and the relative bioavailability of the tablet is only 60% of the bioavailability of the solution.

Time reaches a peak concentration in plasma for about 4 hours and is not different between the form of preparation. Ivermectin has an apparent distribution of about 48 l, and very low clearance (about 1.2 l/ hour). Half life eliminates after taking the solution for about 28 hours. About 93% of the drug is linked to plasma proteins. The metabolism of the drug has not been carefully studied, but it has been hydrolyzed and methyl is removed in the liver. Ivermectin is excreted through bile and eliminates almost only through stool. Less than 1% of the dose is discharged through urine.

Before taking Pizar-3 Davipharm tablets treat infections caused by parasites, worms (1 blister x 4 tablets)

How to use

ivermectin drink with water in the early morning when not eaten or maybe another time, but avoid eating within 2 hours before and after taking the drug.

Dosage

has not determined the safety of children under 5 years old.

Adults and children over 5 years old: use a single dose of 0.15 mg/ kg. Higher doses will increase the harmful reactions, without increasing the effectiveness of treatment. It is necessary to re -treat the same dose every year to make sure to control the worm larvae only onchocerca. If the patient is seriously infected with the larvae into the eyes, it may be more frequent treatment, such as after every 6 months to use the medication once.

Ivermectin dose tutorial to treat onchocerca infection:

Body (kg)

Single dose

15 - 25

26 - 44

45 - 64

65 - 84

≥ 85

3 mg

6 mg

9 mg

12 mg

0.15 mg/kg

Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? Other undesirable effects include seizures, air conditioning, shortness of breath, abdominal pain, abdominal pain and .

When infected, infusion and electrolytes, respiratory aids (oxygen and artificial respiration if needed), use hypertension if hypotension . Causing vomiting or gastric wash as soon as possible. After that, use bleach and other anti -toxic measures if needed to prevent the absorption of more drugs into the body.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Pizar 3 , you may experience unwanted effects (ADR).

Ivermectin is a safe drug, very suitable for broad treatment programs. Most of the unwanted effects of the drug are due to immune reactions to dead larvae. Therefore, the severity of this effect is related to the density of larvae in the skin. Unwanted effects have been notified including fever, itching, dizziness, edema, skin rash, sensitive pain in lymph nodes, sweating, shivering, muscle pain, swelling of joints, swelling of the face (Mazzotti reaction). Hypoglycemic hypotension has been released with sweating, tachycardia and times.

Unwanted effects often occur in the first 3 days after treatment and depending on the dose. The ratio of unwanted effects has been notified very differently. In a report including 50,929 patients using iVemectin, the unwanted effect is about 9%. In areas with high circulation, the ratio of unwanted effects can be much higher.

Here is ADR: In the treatment of worms only onchocerca dose 0.1 - 0.2 mg/ kg:

Common, ADR> 1/100

Osteoarthritis: Demostatic arthritis (9.3%).

lymph nodes: enlarged and lymph nodes in the armpits (10.0% and 4.4%), in the neck (5.3% and 1.3%), groin (12.6% and 13.9%).

Skin: itching (27.5%), skin reactions such as edema, nodules, pustules, skin rash, urticaria (22.7%).

Systemic: Fever (22.6%).

Cardiovascular: Hypotension (1.1%), tachycardia (3.5%).

Central nervous system: headache (0.2%).

No report.

Notify the physician the unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Pizar 3 contraindicated in the following cases:

Patients sensitive to any ingredient of the drug.

Patients with diseases accompanied by brain fence disorders, such as African trypanosoma and meningitis.

Be cautious when using

still do not have much experience using drugs for children under 5 years old, so not for this age.

Due to gaba increased drugs, there is a notion that the drug has the effect on the central nervous system in humans that the brain barrier is damaged (such as in meningitis, Trypanosoma disease).

When treated with Ivermectin for people with worms dermatitis only onchocerca can increase the reaction, more harmful reactions may occur, especially edema and make the condition worse.

To be out of reach of children.

The ability to drive and operate machinery

There is no data showing that the drug has an influence on the ability to drive and operate machinery. However, the unwanted effect of the drug is headache, dizziness, hypotension that may occur. Therefore, it is necessary to be cautious when driving and operating dangerous machines.

Pregnancy

Documents on humans are limited. In a study on a wide area of 14,000 patients taking the drug once a year, in 3 years, 203 babies were born from mothers who used drugs during pregnancy. The results showed that the defects in babies born from mothers who use drugs are not different from the children of mothers who do not use drugs. Because worm larvae are only onchocerca, it is easy to cause blindness, there has been no report on the possibility of teratogenicity, although the drug has been used on a very wide range, so Ivermectin can be used after 3 months of pregnancy.

The period of breastfeeding

Ivermectin secretes breast milk with low concentrations (less than 2% of the drug used). Safety for infants has not been determined, so only this medication is for the mother when it is more beneficial to the mother.

Drug interaction

There has been no notice of harmful drug interactions, but theoretically, the drug can increase the effects of GABA receptors stimulating drugs (such as benzodiazepine and sodium valproat).

Storage

In a dry place, avoid light, the temperature does not exceed 30 ° C.

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