Platra 40mg ACME Formulation Treatment Treatment of Gastroesophageal reflux disease (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Pantoprazole

Ingredient

Composition information	Content
Pantoprazole	40mg

Uses

Indications

Platra drug is indicated in the following cases:

Treatment gastric ulcer, duodenum . out. In terms of chemical structure is the derivative of benzimidazol.

Pantoprazol is not inversely linked to H+/K+ ATPASE is an enzyme system on the surface of the cell into the stomach, so Pantoprazol inhibits the final transport of hydrogen ions into the stomach. Because the H+/K+ ATPASE enzyme system is considered the acid pump (proton) of the gastric mucosa, Pantoprazol is called proton pump inhibitors.

Pantoprazol inhibits the basic acid secretion and is stimulated by any stimulating agent.

Pantoprazol can prevent Helicobacter pylori in people with stomach ulcer - duodenum infected with this bacterium. If combined with one or more anti -bacterial drugs (such as amoxicillin, clarithromycin), pantoprazol can be effective in exporing gastritis caused by H. pylori.

pharmacokinetic

absorption

Pantoprazol quickly absorbed through the gastrointestinal tract, but varies depending on the dose and stomach pH. Oral bioavailability can be up to 70% if used repeated.

Distribution

Pantoprazol is strongly attached to plasma proteins.

Metabolism

Metabolic drugs in the liver.

Elimination

Eliminate drugs through the kidneys 80%, the sale time is about 30-90 minutes.

Before taking Platra 40mg ACME Formulation Treatment Treatment of Gastroesophageal reflux disease (3 blisters x 10 tablets)

How to use

Platra drugs are used orally, once a day in the morning.

Dosage

duodenum ulcer

Take every day 40mg, for 2-4 weeks.

To eradicate Helicobacter pylori, it is necessary to combine pantoprazol with 2 antibiotics in the treatment mode using 3 drugs in a week.

Treatment of gastroesophageal reflux disease

Take 20 - 40mg once a day in the morning for 4 weeks, can increase up to 8 weeks if necessary, in people with unprotected esophagus ulcers after 8 weeks of treatment, can extend the treatment up to 16 weeks.

Maintain treatment: 20 - 40mg per day. Safety and efficiency of maintenance dose for over 1 year has not been determined.

Coordinate with antibiotics in H.P treatment regimen

An effective regimen including Pantoprazol oral 40mg, 2 times a day (in the morning and evening) + Clarithromycin 500mg, 2 times + Amoxicillin 1.0g, 2 times a day or Metronidazol 400mg, 2 times a day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

How to handle

Stomach washing, active carbon, symptomatic treatment and support.

Monitor the activity of the heart, blood pressure. If vomiting is prolonged, water and electrolytes must be monitored.

Because Pantoprazol is strongly attached to plasma proteins, the method of separation does not eliminate the drug.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Platra , you may experience unwanted effects (ADR).

Common, ADR> 1/100

Body: tired, dizzy, headache

Systemic: weakness, dizziness, dizziness, insomnia .

Skin: itching.

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Platra drug contraindicated in the following cases:

Do not use Pantoprazole for cases where a history of sensitivity to Pantoprazole. There is currently no information about Pantoprazole's output through breast milk. Only use pantoprazole when the benefit of the mother is considered greater than the risk for the fetus and the baby.

Caution when using

before using pantoprazol as well as other proton pump inhibitors for stomach ulcers, which must eliminate stomach cancer because the drug can cover symptoms or slow cancer diagnosis.

Be careful when using pantoprazol in people with liver disease (acute, chronic or history). The serum concentration of the drug may increase slightly and mitigate the excretion; But no dose adjustment.

Avoid using when cirrhosis or severe liver failure. If used, the dose should be reduced or given 1 time a day. Must monitor regular liver function.

Use carefully in people with kidney failure, the elderly.

The ability to drive and operate machinery

Not used for drivers and operating machinery.

Pregnancy

only use pantoprazol when really necessary during pregnancy.

Breastfeeding period

Need to consider stopping breastfeeding or stopping the drug, depending on the benefits of Pantoprazol with the mother.

Drug interaction

pantoprazol changes the absorption of drugs that depend on pH such as: ketoconazol.

Pantoprazol is metabolized in the liver thanks to the cytochrom P450 enzyme system. Therefore, Pantoprazol has the ability to interact with drugs metabolized by this enzyme.

However, clinical clinicals have not seen significant interaction between pantoprazol and drugs: carbamazepin, caffeine, diazepam, diclofenac, digoxin, ethanol, glibenclamid, metoprolol, nifedipine, phenytoin, theophyline, warfarin and oral contraceptives used as oral.

Do not see pantoprazol interacting with antacids when used simultaneously.

There is no interaction with combined antibiotics (amoxicillin, clarithromycin) to treat Helicobacter pylori.

Storage

Store in a dry place, the temperature does not exceed 30 ° C, avoiding light.

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