PMS-Azimax 500mg Imexpharm Treatment Treatment (1 blister x 3 tablets)

Dosage form Box of 1 blister x 3 tablets
Specifications Azithromycin
Ingredient Imexpharm

Ingredient

Composition information	Content
Azithromycin	500mg

Uses

indications

PMS - Azimax 500 mg drug is indicated in the following cases:

azithromycin is indicated in the treatment of infections caused by drugs that are sensitive to drugs such as:

Upper respiratory infections: ear - nose - throat infections such as sore throat, sinusitis, tonsillitis, otitis media. Exhortation. Lower soft oranges made by Haemophilus ducreyi. The bactericidal effect of the drug obtained by azithromycin is connected to the subunit of 50s of the bacterial ribosom, which hinder the bacterial protein synthesis.

Azithromycin has in vitro antibacterial validity for Gram -positive bacteria and grams including: Staphylococcus aureus, s.pneumoniae, Streptococcus pyogenes (group A); Other strains of strains such as Haemophilus parainfluenzae, H.influenzae, Branhamella CatVrhalis; Anaerobic bacteria include: Bacteroides Fragilis, E.coli, Bordetella Pertussis, Haemophilus Ducreyi, Bordetella Parapertussis; Neisseria Gonorrhoeae and Chlamydia Trachomatis. Azithromycin also works on some other bacteria such as Legionella Pneumophila, Mycoplasma Pneumoniae, Mycoplasma Hominis, Campylobacter sp. and treponema pallidum.

Dynamic pharmacokinetics

azithromycin absorb well after oral, biological use about 40%. After taking the medication, the peak concentration in plasma is reached within 2 to 3 hours. The drug is distributed mainly in tissue such as lungs, tonsils, prostate glands, granulocytes, higher macrophages in the blood. The half -life of azithromycin is from 11 - 14 hours when measuring over 1 day. After the dose repeated, the excretion time increased to about 57 hours, mainly due to slow release. The half -life of the drug from different tissues is 2-4 days.

azithromycin is excreted mainly in feces, bile and very little through the urine. Most azithromycin is excreted in a constant form, only a small amount is excreted in the form of metabolism. In case of liver failure, severe kidneys must adjust the dose.

Before taking PMS-Azimax 500mg Imexpharm Treatment Treatment (1 blister x 3 tablets)

How to use

Take oral use.

Take azithromycin once a day, should take medicine 1 hour before meals or 2 hours after meals due to food reduces Azithromycin absorption.

Dosage

Adults

Infectious and lower respiratory infections, Skin and soft tissue infections: The starting dose of 500 mg, 04 days after each day taking 250 mg.

Genital transmission disease: single dose 1 g.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? Typical symptoms of the use of macrolid antibiotic overdose include recovery, nausea, vomiting and diarrhea.

If overdose, active carbon indications, symptomatic treatment and supportive measures.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using PMS - Azimax 500 mg, you may experience unwanted effects (ADR).

Most adverse effects occur in the gastrointestinal tract (nausea, vomiting, abdominal pain, diarrhea). Like other macrolides and penicilin, sometimes there is an increase in liver transaminase recovery. Sometimes there is temporary decrease in neutrophils in clinical trials.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

PMS - Azimax 500 mg contraindicated in the following cases:

PMS - Azimax 500 mg is contraindicated in the following cases:

sensitive to azithromycin or with other antibiotics of the MacRolid family.

Caution when using

Special Warning

Leave a cool dry place to avoid light and reach of children. Azithromycin must be prescribed as directed by the doctor.

Be cautious when using

azithromycin should only be used one hour or two hours after eating or taking antacids.

As with other antibiotics, during the use of drugs, the signs of superinfection must be observed because bacteria are not sensitive to the drug, including fungi. No need to adjust the dose for people with renal failure.

The ability to drive and operate machinery

should be cautious when used for driving objects and operating machinery.

Pregnancy

The effects of the above drug's effects have the fertility of animals that azithromycin through the placenta, but no harmful effects on the fetus. There is no data on the use of drugs on pregnant women.

Because studies affect the fertility of animals on animals is not always right on humans, so they do not use azithromycin for pregnant women, unless there is no alternative drug.

Lactation period

Not for pregnant and lactating women if not really necessary.

Drug interaction

digoxin: Macrolid antibiotics reduce digoxin metabolism, so it is capable of increasing blood digoxin, so it is necessary to check digoxin levels during treatment.

Carbamazepin: Be careful when coordinating with azithromycin because there are some macrolid antibiotics that increase carbamazepine concentration in plasma leading to overdose.

Cyclosporin: Some macrolid antibiotics affect the metabolism of cyclosporin. Need to quantify the concentration of cyclosporin in plasma and adjust the dose accordingly.

Antacids: It is best to take azithromycin 1-2 hours before or after the antacid dose because these drugs affect the absorption of azithromycin.

As well as other macrolid antibiotics, azithromycin should not be used simultaneously with alkaloids of chicken spurs.

Patients need to notify other physicians to be used simultaneously, such as Terfenadin, Cisapride, Theophyllin, Warfarin ... during treatment with azithromycin.

Storage

In a dry place, avoid light, temperature below 30 ° C.

Other drugs

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