PMS-Ciprofloxacin 500mg treatment of severe infections (2 blisters x 10 tablets)

Dosage form Box of 2 blisters x 10 tablets
Specifications Ciprofloxacin
Ingredient Middle otitis, malignant outer otitis, chronic sinusitis, cervicitis, testicular inflammation, urethritis, skin and soft tissue infection, pneumonia, bone inflammation

Ingredient

Composition information	Content
Ciprofloxacin	500mg

Uses

Indications

Ciprofloxacin 500mg drug is indicated in the following cases:

ciprofloxacin 500 - HV is used for treatment in severe infections such as:

Respiratory infections, otitis media, sinusitis especially causes Gram -negative bacteria, including pseudomonas or staphylococcus.

Genital infections, gonorrhea, appendages, prostatitis.

Gastrointestinal or biliary tract infections, peritonitis.

Skin infections and soft tissue, osteoarthritis.

Severe infections in the hospital (blood infection, immunodeficiency).

Read carefully for use before use. If you need more information, please consult your doctor.

This drug is only used as prescribed by a physician.

Pharmacokic of

Ciprofloxacin is a semi -synthetic antibiotic, with wide antibacterial spectrum, belonging to Quinolon group, also known as DNA inhibitors. Ciprofloxacin works well with antibiotic -resistant bacteria of other groups (aminoglycosides, cephalosporin, tetracyclin, penicilin ...) and is considered one of the most powerful drugs in the fluoroquinolone group.

antibacterial spectrum includes

Ciprofloxacin has a very wide antibacterial spectrum, including most important pathogens. Most gram -negative bacteria, including pseudomonas and enterobacter are sensitive to the drug. Gram -positive bacteria (Enterococcus strains, Staphylococcus, Streptococcus, Listeria monocytogenes ...) are less sensitive. Ciprofloxacin does not work on most anaerobic bacteria.

Bacteria that cause intestinal diseases such as Salmonella, Shigella, Yersina and Vibrio Cholerae are often highly sensitive. The bacteria that cause respiratory diseases such as Haemophilus and Legionella are often sensitive, Mycoplasma and Chlamydia are only sensitive to the drug. Neisseria is often very sensitive to drugs.

Mechanism of action

Ciprofloxacin inhibits DNA Gyrase enzyme, prevents Chromosom's copy that makes bacteria not reproduce quickly.

pharmacokinetic

absorption

Ciprofloxacin absorbs quickly and easily in the digestive tract. When food and anti -acid drugs, the absorption of drugs is slower but not significantly affected. After drinking, the maximum concentration of Ciprofloxacin in the blood appears after 1-2 hours with absolute biological available 70-80%. Maximum maximum concentration in serum corresponding to 50mg doses is 2.4mg/liter.

Distribution

The distribution of ciprofloxacin is very large (2 - 3 liters/kg body weight). The drug is widely distributed and has high concentrations in places where infections (body fluids, tissues). The concentration in tissue is usually higher than the serum concentration, especially in parenchyma, muscle, bile and prostate. Ciprofloxacin passes through the placenta and excreted through breast milk.

Metabolism

Half of life in plasma is about 3.5 to 4.5 hours in patients with normal kidney function, this time is longer in patients with kidney failure and in the elderly.

Elimination

about 40 - 50% of oral dose is eliminated in the form of unchanged urine by filtering in the glomerular filter and excreted in the renal tubules. Other excreted lines are metabolic in the liver, excreted bile, and excreted through the mucosa into the intestine (this is a mechanism of clearing compensation in patients with severe kidney failure). The drug is excreted within 24 hours.

Before taking PMS-Ciprofloxacin 500mg treatment of severe infections (2 blisters x 10 tablets)

How to use

Take oral use, patients should take medicine for 2 hours after meals, should take plenty of water and do not take anti -stomach drugs for 2 hours after taking the drug.

Dosage

Dosage and medication time for each specific case as prescribed by the treating doctor.

Ciprofloxacin treatment time depends on the type of infection and the severity of the disease. For most infections, the treatment should continue at least 48 hours after the patient has no symptoms. The treatment time is usually 1-2 weeks, but with severe or complicated infections, may need longer treatment.

Respiratory infections (depending on mild severity and pathogenic bacteria): 250 - 500mg x 2 times/day.

Grant urinary infection: 250 - 500mg x 2 times/day.

Cystitis in women: The only dose of 500mg, with complications: 500 - 750mg x 2 times/day.

Gonorrhea outside the genitals: 250mg x 2 times/day.

Inhan complications: The only dose 500mg.

diarrhea: 500mg x 1 - 2 times/day.

Other infections: 500mg x 2 times/day.

Life -threatening infections: 500 - 750mg x 2 times/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

What to do when forgetting a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Ciprofloxacin 500mg, you may experience unwanted effects (ADR).

On the digestive system: nausea, vomiting, diarrhea, abdominal pain, uncomfortable flatulence, loss of appetite.

On the nervous system: headache, dizziness, dizziness, fatigue, insomnia, tremor, loss of air conditioning, epilepsy or convulsions, especially in confusion, anxiety, depression.

On the respiratory system: shortness of breath, nosebleeds, larynx edema or lungs, coughing blood, bronchial spasms, pulmonary obstruction.

may also experience other but very rare side effects: erythema, hemorrhage under the skin, increased heart rate, joint pain, hepatitis.

Instructions on how to handle ADR

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Ciprofloxacin 500mg drug is contraindicated in the following cases:

People with a history of hypersensitivity to ciprofloxacin and related drugs such as nalidixic acid and other quinolons.

Do not use ciprofloxacin for pregnant women and lactation period, unless the benefits are greater than the risk of the drug.

Precautions when using

Be careful when using ciprofloxacin for people with a history of epilepsy or central nervous system disorders, people with liver function or kidney function, people with Glucose 6 phosphate dehydrogenase, people with muscle weakness.

The long -term use of ciprofloxacin can cause non -sensitive bacteria to overdue drugs. It is necessary to monitor patients and make antibiotics regularly to take appropriate treatments according to antibiotics.

ciprofloxacin can make mycobacterium tuberculosis tests negative.

Ciprofloxacin can cause dizziness, whirling mind, affecting vehicles or operating machinery.

Restriction of using ciprofloxacin for young children and growing children (under 18 years old) because of the experiment, the drug has cartilage degeneration in gravity joints.

The ability to drive and operate machinery

The drug can affect the speed of reflection to the level of reducing the ability to drive and operate machinery, the effect increases when used with alcohol.

Pregnancy

should only use Ciprofloxacin for pregnant women in cases of severe bacterial infections without other antibiotics instead, forced to use ciprofloxacin.

Breastfeeding period

Do not use ciprofloxacin for nursing mothers, because ciprofloxacin accumulates in milk and can reach the concentration that can cause harm to children. If the mother is forced to use ciprofloxacin, they must stop breastfeeding.

Medicinal interaction

Concomitance nonsteroidal anti -inflammatory drugs (ibuprofen, indomethacin ...) will increase the side effects of ciprofloxacin.

Concomplified anti -acid drugs with aluminum and magnesium will reduce serum levels and reduce bioavailability of ciprofloxacin.

Iron products (Fumarat, Gluconate, Sulfate) significantly reduce the absorption of ciprofloxacin in the intestine. Zinc preparations have less effects.

Take the sucralfate at the same time will reduce the absorption of ciprofloxacin significantly. Antibiotics should be given 2 - 6 hours before taking sucralfat.

Ciprofloxacin absorption may be reduced half if used simultaneously some cyclophosphamide, vincistin, doxorubicin, cytosin arabinosid, mitozantron).

If using the Convidinosin simultaneously, the concentration of ciprofloxacin is significantly reduced. Ciprofloxacin should be taken before using Didanosin for 2 hours or after using Didanosin 6 hours.

Take Ciprofloxacin simultaneously with theophylin may increase theophylin level in serum, causing the side effects of theophylin. The chest of theophylin concentration in the blood, and may be reduced by theophylin if it is forced to take 2 drugs.

ciprofloxacin and ciclosporin use simultaneously can cause temporary increased serum creatinine. Should check blood creatinine twice a week.

Probenecid reduces glomerular filtration level and reduces the excretion in the renal tubules, thus reducing the elimination of drugs through urine.

Warfarin in combination with ciprofloxacin can cause prothrombin lowering, regular examination of blood prothrombin and adjusting anticoagulant dose.

Storage

Store drugs in a dry place, temperatures below 30 ° C, avoiding light.

To be out of reach of children.

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