PMS-Zanimex 500mg Imexpharm Treatment Treatment of ENT infection (2 blisters x 5 tablets)

Dosage form Box of 2 blisters x 5 tablets
Specifications Cefuroxim

Ingredient

Composition informationContent
Cefuroxim500mg

Uses

Indications

Zanimex 500 are indicated in the following cases:

  • Infection with ear, nose and throat: otitis media, sinusitis, tonsillitis, pharyngitis.
  • Skin infections and soft tissue: Impastation, pus disease, boils.
  • Inventure of gonorrhea.

    • Pharmacology

    cefuroxim is a broad -spectral semi -synthetic antibiotic belonging to the cephalosporin group. Cefuroxim has antibacterial activity due to synthetic inhibition of bacterial cell walls by engaging in essential target proteins.

    Cefuroxim has antibacterial activity on many common pathogens, including beta -lactamase strains of gram -positive and gram -negative bacteria. Cefuroxim is especially durable with many beta enzymes - lactamase of Gram -negative bacteria.

    antibacterial spectrum:

  • Gram -negative aerobic: E. Coli, Klebsiella Sp, Proteus Mirabilis, Providencia Sp, Proteus Rettgeri, Haemophilus Influenzae (including ampicillin resistance strains), Haemophilus parainfluenzae, Branhamella Catacrhalis, Neensseria (Including strains with penicillinase and non -penicillinase secretion).

    • Gram -positive aerobic: Staphylococcus aureus and Staphylococcus epidermidis (including penicillinase production strains except methicillin strains), Streptococcus group B (Streptococcus agalactiae), Streptococcus pyogenes (and streptocciCci Beta), Streptococcus pneumoniae.

  • Anaerobic: Gram -positive and gram -negative bacteria (including peptococcus and peptostreptococcus spp). Gram -positive bacillus (including Clostridium sp) and Gram -negative bacilli (including Bacteroides and Fusobacterium spp), propionibacterium sp.

    • Dynamic pharmacy

    cefuroxim is absorbed through the gastrointestinal tract after drinking. Cefuroxim is widely distributed throughout the body. The drug through the bloody barrier when the meninges are inflamed. The drug is given the placenta and is excreted through breast milk. The maximum concentration in the serum is about 2-3 hours after drinking during meals. Serum half -life is from 1 to 1.5 hours. Cefuroxim is not metabolized and eliminated in the form of non -variable according to the glomerular filtration mechanism and excreted in the renal tubules.

    Before taking PMS-Zanimex 500mg Imexpharm Treatment Treatment of ENT infection (2 blisters x 5 tablets)

    How to use

    Treatment time from 10 - 14 days.

    Should take PMS-Zanimex at meals to increase bioavailability. Swallowing the tablet, should not be chewed due to the bitter taste.

    Dosage

    Adults

    Most infections: 250 - 500 mg x 2 times/day.

    Urinary infection: 125 mg x 2 times/day.

    Lower respiratory infections: 250 - 500 mg 2 times/day, depending on the infection.

    Nephritis - Pyelonephritis: 250 mg x 2 times/day.

    Inhabited illegal: single dose 1 g.

    New lympha disease: 500 mg x 2 times/day, for 20 days.

    Patients with renal failure

    Creatinine clearance (ml/minute)

    Dosage

    ≥ 20

    No dose adjustment

    Discount 50% of the dose compared to normal doses, drink 1 time/day.

    Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

    Most of the nausea, vomiting, diarrhea, in addition can cause muscle stimulation and seizures, especially in people with kidney failure.

    Handling

    Protects the respiratory tract for patients, ventilation and infusion. If convulsions, stop drugs, use anti -seizure measures. Hemorrhage can be from the circulatory system.

    What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

    Side Effects

    Common, ADR> 1/100

  • Digestive: diarrhea.
  • Skin and subcutaneous tissue: lumpy skin.

    • Uncommon, 1/1000

  • Digestive: Nausea, vomiting.

    • blood and lymphatic system: Eosin hypernagus, leukopenia. Systemic: urticaria, itching, anaphylactic reaction, candidiasis.

    Rare, ADR

  • Blood: Hemolytic anemia.
    • digestive: fake colitis.

    Mile liver: jaundice. kidney - Urinary: Acute renal failure and interstitial nephritis.

    Instructions on how to handle ADR

    When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

    Warnings

    Contraindicated

    Zanimex 500 contraindicated for the following cases:

  • Hypersensitivity to antibiotics of cephalosporin and ingredients of the drug.

    Be cautious when using

    there has been a report of fake colitis when using broad spectrum antibiotics. Therefore, it is necessary to pay attention to this diagnosis in patients with severe diarrhea related to the use of antibiotics. Be careful to use this medication for people with gastrointestinal diseases, especially colitis.

    Prolonged treatment with Cefuroxim may increase non -sensitive bacteria. Need to follow the patient carefully. If serious superinfection during treatment, the drug must be stopped.

    Be careful when giving patients simultaneously with strong diuretic drugs because it can have adverse effects on kidney function.

    PMS-Zanimex 500 mg films have high content that is not suitable for children. If necessary, use a lower level of tablets.

    The ability to drive and operate machinery

    There has been no recognition of the impact of the drug on the ability to operate machinery and driving. However, it is advisable to notify patients with unexpected effects such as: discomfort, headache when taking the drug.

    Pregnancy

    There has been no complete research on drug use for pregnant women. Need to be cautious when using; Should consider the benefits of the mother and the danger to the fetus.

    Lactation period

    cefuroxim excreted into milk, should stop breastfeeding during treatment.

    Drug interaction

    ranitidin, sodium bicarbonate

    Reduce the bioavailability of Cefuroxim. Cefuroxim should be used at least 2 hours after the antacids or H2 histamine receptors, as these drugs can increase the stomach pH.

    Probenecid high doses

    Reducing Cefuroxim's clearance in the kidneys, making the serum cefuroxim level higher and longer.

    aminoglycosides or strong diuretics

    Increases the likelihood of kidney poisoning.

    Cefuroxim can affect the bacteria in the intestine, reducing estrogen recovery. Therefore, the drug can reduce the effects of oral drugs containing estrogen and progesterone.

    • Storage

    Leave a cool place, avoid light, temperature below 30⁰C.

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