Potriolac 15g TW2 skin gel treatment on the spot scales

Dosage form Tube x 15g
Specifications Calcipotriol, betamethasone

Ingredient

Composition information	Content
Calcipotriol	0.75mg
Betamethasone	75mg

Uses

Indications

Potriolac Gel drugs are indicated in the following cases:

Medicines for people aged 18 and over to treat diseases:

Treatment on the spot scales in the scalp and in other areas.

Psoriasis is usually mild.

Psoriasis generated by skin cells giving birth too quickly, causing skin redness, creating scales, thick skin. Potriolac Gel contains active ingredients Calcipotriol and betamethasone. Calcipotriol helps cells return to normal growth, and betamethasone reduces inflammation.

Pharmacokological

betamethasone is an adrenal corticosteroid with anti -inflammatory anti -itching, vasoconstriction, and immune cancellation. Anti -inflammatory mechanism is unknown. If the bundle is applied, it will increase the permeability of the horny layer for betamethasone.

However, there is an assumption that betamethason is like hormones with potential anti -inflammatory, immunosuppressant properties in the gel that operates by blockade and activity of phospholipase enzymes A2, as well as COX1 and COX2 (cyclooxygenase) enzymes for Prostaglandin synthesis.

Calcipotriol is a synthetic derivative of vitamin D3, Calcipotriol attached to vitamin D receptors, minimizing the regulation of calcium metabolism, calcificationriol is considered to be similar to vitamin D in the process of canceling and inhibiting in-vitro horn horns, repairing the abnormalities of these cells in the process of plywood.The above results show that the Potriolac gel has a combination of both active ingredients Betamethason and Calcipotriol 50/500 for psoriasis treatment than using monomers in inflammation, horny cells in psoriasis. Moreover, the drug helps immune cells to be filtered, restoring normal cell growth, reducing scales and thickness of psoriasis, and soothes the symptoms of psoriasis.

pharmacokinetic

absorption

Research results show that the body absorption of Calcipotriol and Betamethasone in the formula is less than 1% of the dose (2.5g potriolac gel) when applied to normal skin has an area of 625cm2 in 12 hours. For psoriasis psoriasis and tape after applying the drug, it increases the absorption of corticosteroids. For damaged skin, the drug can be absorbed 24%.

Distribution

Skin is not damaged, both betamethasone and calcificationroot concentrated in horned tissues. In the case of damaged and body absorption, calcable Calcipotriol is distributed in tissues, betamethasone is distributed mainly in the kidney.

Metabolism

Effects on the spot both calcableriol and betamethasone retain the structure. In the case of absorption of both calcium and betamethasone metabolic in the liver into an active and can metabolize the kidneys of the glucuronic ester kidney.

Elimination

In the case of body absorption, the sale time is 5-6 hours. Calcipotriol is eliminated through bile and in the form of metabolism for 24 hours. And betamethason is eliminated through the inactive urine.

Before taking Potriolac 15g TW2 skin gel treatment on the spot scales

How to use

Use a hair brush to remove psoriasis, can brush the throne. Shake the tube and open the lid.

Squeeze the medicine into the fingers. Tilt your head before applying the drug to avoid the drug flow into the face, eyes, mouth.

Apply gel gel to the psoriasis area. Then use the tip of the fingers to gently. Wash your hands carefully after taking the drug. Avoid spreading the medicine to other areas such as face, eyes, mouth.

If the drug is stick to the eyes, wash your eyes immediately with clean water and see a doctor.

If you accidentally apply the drug to the skin without compressed scales, must wipe off the drug as soon as possible.

Do not cover the skin or bundle the skin to avoid the drug absorbed into the blood.

To promote the drug effectively, do not wash your hair immediately after applying the drug but leave the drug in the topical or overnight position, or leave it all day.

Because hair is dry, rubbing a little shampoo into the topical area. Then leave for 1 - 2 minutes and then wash your hair as usual.

Dosage

Each day using 1 time: the amount of medicine is enough for the scalp area from 1 - 4 g (1 teaspoon) per day. Shake the gel before applying, squeeze the tip of the fingertips clean or directly the medication area, then apply the drug gel to the infected skin, wash your hands immediately after applying the drug. If applying the drug too much, it is necessary to wipe the drug without being sick.

Do not wash or bathe, wash your hair where the drug is applied immediately after applying the drug. Should leave the medicine at the place of topical or 1 night. When applying and tilting your head to avoid the drug flow into the eye and face area. Do not take the drug in excess of 15g of the total amount of drugs a day (including other forms of preparation containing calcificationriol) or not applying the topical area, as it can cause high blood calcium and systemic corticosteroid absorption causes cortisol response to ACH. Do not use more than 100g of Calcipotriol drugs per week. Do not apply medicine to over 30% of the body skin area. There is no recommendation for children under 18 years of age. The drug time is 4 weeks applied for the treatment of scalp psoriasis, 8 weeks for psoriasis not in the scalp area.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Treatment by stopping the drug until the blood calcium returns to normal.

Moreover, the drug contains corticosteroids, if the wrong drug is used for a wide skin red psoriasis, can be toxic to the top of the medication that lasts more than 5 months and the dosage on 34g of drugs per day, may appear millions of eggs impaired adrenal gland function - thyroid, secondary adrenal insufficiency, stopping the drug suddenly causing Cushing syndrome.

Handling

For symptoms caused by calcificationriol, stop taking the drug until blood calcium returns to normal. For symptoms caused by betamethasone by reducing the dose and treating systemic symptoms. If you swallow the gel or show signs of poisoning, you need to go to a doctor and medical care.

What to do when forgetting a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Potriolac Gel, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Skin: itching.

Uncommon, 1/1000

Skin: irritation of the eye, feeling hot skin, pain or skin irritation, folliculitis, itching due to dermatitis, redness due to varicose veins, dry skin, skin infections.

Rare, 1/10000

Skin: allergic reactions, thin skin, changing hair growth, skin around the mouth, burning contact dermatitis, mild skin discoloration, severe folliculitis.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Potriolac gel drugs in the following cases:

Hypersensitivity to Calcipotriol, Bethamethasone and catch any ingredients of the drug.

Because the gel contains calcableriol, it is contraindicated for patients with calcium metabolic disorders.

The drug also contains corticosteroids, which should be contraindicated for cases of viral skin lesions (herpes, varicella), fungal skin, bacterial infections, parasites such as scabies, tuberculosis, dermatitis around the mouth, skin heterotrophy, ordinary acne, red acne, ulcers and injuries, wrinkles, floating, and then inferior disorders. Use medication for facial, eyes, skin with many folds such as groin, armpits, areas under the breast or tape the skin after applying the drug.

Do not take the same medication and treatment with other drugs containing corticosteroids.

Not used for red psoriasis, peeling and pustules.

Precautions when using

for people with specialized dysliages, should periodically quantify blood calcium to adjust the dose.

Need to supervise specialized physicians when applying drugs to over 30% of body skin area.

For patients with diabetes, blood sugar levels should be monitored to adjust the dose and anti -diabetes drugs.

Limit the use of drugs in the genital area, the risk of infection.

Limit the use of drugs in the skin using the drug in contact with sunlight.

The ability to drive and operate machinery

potriolac gel does not affect driving and operating machinery.

Pregnancy

Research on mice through prolonged oral corticosteroids, resulting in that the preparation containing corticosteroids shows signs of reproductive toxicity (such as platelets, waveform deformity), on prolonged pregnancy and hard labor, long -term labor, reducing body mass, reducing survival of the child's generation. However, the results of epidemiological research on about 300 pregnant women treated with corticosteroids do not see the genital abnormalities of the baby born.

Thus the potential risks for people who have not yet confirmed, Potriolac Gel is only used for pregnant women when carefully considered between the potential benefits of the drug and the potential risk of the drug.

Breastfeeding period

Bethamethason through breast milk, the risk of unwanted effects for children is not yet known for treatment. There is currently no data published about the excretion of Calcipotriol into breast milk. Therefore, the instructions should not be used for Potiriolac Gel during breastfeeding.

Medicinal interaction

Modable interaction may occur when using drugs on wide skin. CYP3A4 metabolic inhibitors can affect the bioavailability of the drug such as bromocriptine, dexamethasone, erythromycin, ketoconazole, miconazole, omeprazole ...

Should avoid using the drug simultaneously with UVA, UVB treatment therapy or combined with Psoralen (Puva).

Storage

In a dry place, temperatures below 30 ° C, avoid light.

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