Powder mixed with Claminat IMP 500mg/62.5mg infection treatment (12 packs)

Genital urinary infections such as cystitis, urethritis, nephritis, pyelonephritis, female genital infections and gonorrhea.

Skin infections and soft tissue.

Bone and joint infections such as osteomyelitis.

Other bacterial infections such as infections, postpartum infections, postpartum infections, infections in the abdomen.

Pharmacy

Pharmacological group: Coordination of penicillin group, including beta-lactamase inhibitors.

ATC code: J01CR02.

Amoxicillin is a semi -synthetic antibiotic with wide antibacterial spectrum against many Gram -positive and gram -negative bacteria. However, amoxicillin is easily decomposed by beta-lactamase enzymes, so the effect of Amoxicillin is used alone does not include these bacteria.

Clavulanic acid is a beta-lactam, structurally related to penicillin, capable of inactiveness of many types of beta-lactamase yeast commonly seen in resistance to penicillin and cephalosporin. In particular, clavulanic acid works well against beta-lactamase specified by plasmids that often cause propagation resistance. Clavulanic acid often affects the Beta-lactamase type 1 specified by chromosomes.

The presence of clavulanic acid protects amoxicillin from decomposition by beta-lactamase enzymes, thus expanding amoxicillin antibacterial spectrum includes many common bacteria resistant to amoxicillin and other cephalosporins. Therefore, combination of amoxicillin and clavulanic acid has a special feature of a broad-spectrum antibiotic and a beta-lactamase inhibitor.

Bacterial spectrum:

common sensitive bacteria

Patients with a history of serious hypersensitivity (eg anaphylaxis) with other drugs belonging to the beta-lactam group (such as cephalosporin, carbapenem or monobactam).

Patients with a history of jaundice or liver dysfunction related to amoxicillin and clavulanic acid.

Precautions when using

Before starting treatment with Claminat 500mg/

62.5mg, need to learn about the patient's allergic history with penicillin, cephalosporin or other beta-lactam drugs.

Patients treated with penicillin may have severe hypersensitivity reactions and sometimes fatal (anaphylaxis). These reactions are likely to occur in patients with a history of penicillin sensitivity and patients with allergies. If allergic reactions occur, medication must be discontinued and have appropriate alternative treatments.

In the case of Beta-lactamase enzymes secreted by bacteria, which is not inhibited by clavulanic acid, which leads to resistance to bacteria with beta-lactam antibiotics, does not use Claminat 500mg/62.5mg for treatment. Do not use this medication to treat S.pneumoniae resistant to penicillin.

Convulsions can occur in patients with impaired renal function or patients using high doses.

It is necessary to avoid Claminat 500mg/62.5mg for patients with mononoculatoculus hyperlemen due to the high risk of rash in these patients if they use amoxicillin. Using allopurinol while being treated with amoxicillin may increase the risk of skin allergies.

Take the drug that lasts sometimes causes excessive growth of non -sensitive bacteria.

The appearance of all -body typhus with pustules at the beginning of the treatment may be a symptom of the acute all -body pustules syndrome (AGEP). When there are signs, patients need to stop taking the drug and do not use amoxicillin -containing drugs to treat the disease in later cases.

Be cautious when using Claminat 500mg/62.5mg for patients with impaired liver function. Cases of liver occur mainly in male patients, elderly patients and prolonged and rare patients in children. Typically, signs and symptoms usually occur during the process or after a short time of treatment, but in some cases, it may not be clear until several weeks after stopping treatment. These symptoms can often recover from themselves, but there are still cases of severe, even death, but very rare, often occurs in patients with serious illness or use in combination with drugs that affect the liver.

Colitis caused by antibiotics occurs with most antibiotics, including amoxicillin, the level of mild to life -threatening fluctuations. Therefore, this diagnosis should be noted in patients with diarrhea during or after any antibiotic use. If antibiotic colitis occurs, stop taking the drug immediately and have appropriate treatment. Contraindicated anti -spasms in this case.

periodically evaluate the function of organ systems, including liver, kidney function and hematopoietic system during prolonged treatment.

Increasing blood clotting time may occur and rarely in patients using amoxicillin and clavulanic acid. Patient status should be monitored when used simultaneously with anticoagulant drugs and adjust the dose of appropriate anticoagulants.

Little urine patients may experience crystal but rare cases, mainly occur when taking injection drugs. When using high doses of amoxicillin, it is necessary to balance the amount of drinking water and release to reduce the ability to form amoxicillin crystals. The bladder pipes must be checked regularly to avoid precipitation causing clogging when there is a high concentration of preparations in the urine.

Patients with urinary phenylceton and patients need to control phenylalanin to be cautious when taking Claminat 500mg/62.5mg because the drug contains aspartame will be converted in the digestive tract into phenylalanin.

Claminat 500mg/62.5mg contains manitol that can cause light laxative.

While treating amoxicillin, the glucose oxidase enzyme should be used when it is necessary to test glucose in the urine because non -enzyme methods can give false positive results.

Clavulanic acid causes nonsense cohesion of IgG and albumin on the red blood cell membrane, resulting in a false positive result of the Coombs test.

The drug can cause false positive testing Bio-Rad Laboratories Platelia Aspergillus EIA due to cross-reactions with polysaccharide and polyfuranose are not Aspergillus. Therefore, for patients who are taking amoxicillin and clavulanic acid, should be cautious when reading the results if there is a positive result when tested by this method and should be redefined by other diagnostic methods.

The ability to drive and operate machinery

There is no adequate research to prove that the drug affects the ability to drive and operate machinery. However, unwanted effects such as allergies, dizziness, convulsions, ... can reduce the ability to focus and react of the patient, therefore, should be careful when driving and operating machinery if using the drug.

Pregnancy

Use drugs for pregnant women:

Claminat medicine 500mg/62.5mg does not cause congenital deformities. In premature women, early rupture of amniotic fluid, the drug increases the risk of necrotizing intestinal inflammation in newborns. Therefore, avoiding drugs during pregnancy, unless the doctor is indicated.

Breastfeeding period

amoxicillin and clavulanic acid are both breast milk. Therefore, diarrhea and fungal infections on mucous membranes can occur in infant breastfeeding, need to stop breastfeeding when babies have the above manifestations. Only use the drug during breastfeeding after evaluating benefits and risks from a doctor.

Medicinal interaction

Oral anticoagulant drugs: combination of oral anticoagulants and penicillin antibiotics are widely used in practice without reporting on interaction.

However, there have been cases of increased international normalization index in patients using acenocoumarol or warfarin in combination with amoxicillin. In case of simultaneous use, prothrombin should be monitored or international chemical index and adjust the anticoagulant dose when needed.

methotrexate: Amoxicillin reduces methotrexate secretion, increases the risk of toxicity.

Probenecid : reduces amoxicillin secretion in the renal tubules and can increase, prolong the concentration of amoxicillin in the blood but do not increase clavulanic acid. Therefore, do not use the drug simultaneously with Probenecid.

nifedipin : Increases amoxicillin absorption.

Oral contraceptive pills: like antibiotics with broad -effects, the drug can reduce the effectiveness of oral contraceptives, so it is necessary to notify the patient in advance.

Allopurinol: Patients with hyperuricemia when using simultaneously Allopurinol along with amoxicillin will increase the ability of amoxicillin.

Bacterial substances: There may be antagonists between amoxicilin and bactericidal substances such as fusidic acid, chloramphenicol , tetracyclin.

affect clinical tests: