PowerCort Cream Glenmark skin cream is short -term treatment of dermatological diseases, psoriasis, Eczama (15g)

Dosage form Tube
Specifications Clobetasol Propionate

Ingredient

Composition information	Content
Clobetasol Propionate	0.05% (KL/KL)

Uses

Indications

PowerCort cream has an effective effect in short -term treatment (less than 2 weeks) Dermatological diseases such as psoriasis (except for psoriasis psoriasis are wide -growing), hard -to -treat eczema, flat lids, disc red and other skin diseases that do not respond to weaker corticosteroids.

Pharmacokic

Clobetasol Propionate is a corticosteroids used in the skin with strong effects. It has anti -inflammatory, immunosuppressive and anti -proliferation effects. Anti -inflammatory effects are caused by a decrease in the formation, release and activity of intermediate inflammatory substances such as kinin, histamine, enzymes of liposom, prostaglandin, leukotrien thus reducing the initial manifestations of the inflammatory process.

Corticosteroids inhibit the grip and white blood cell movement to the damaged areas, reverse the vasodilation and increase the permeability of the vascular wall, resulting in reducing the approach of white blood cells to the damaged area. Vascular contractions reduce serum escape, reduce swelling and reduce discomfort.

Immunosuppressant effects reduces response to hypersensitivity reactions immediately and late (tubes III and IV). This is due to the inhibition of toxic effects of antigen and antibodies in the vascular wall to create skin allergic vasculitis; And due to the inhibition of the effects of lymphokin, target cells and macrophages, they together cause allergic contact dermatitis reactions. In addition, the corticosteroids can prevent the approach of sensitive t leukocytes and macrophages to the target cell. Anti -proliferation effects reduces tissue hyperplasia due to psoriasis.

Clobetasol causes lipocortin induction are phospholipase inhibiting proteins A2. As a result, Clobetasol prevents the production of intermediate inflammatory substances, prostaglandin and leukotrien, thereby inhibiting inflammatory reactions.

Dynamic pharmacokinetics

The drug can be absorbed through the skin depending on the condition of the skin. Usually less than 5% of the dose is absorbed through normal healthy skin. However, absorption can be more when the skin is inflamed or icy, helps increase the permeability of the skin epidermis.

Before taking PowerCort Cream Glenmark skin cream is short -term treatment of dermatological diseases, psoriasis, Eczama (15g)

How to use

Apply the skin at the position to be effective.

Dosage

Apply a thin layer of cream and gently rub the damage once or twice daily until healing. As well as highly active steroids used other, it is necessary to stop treating when the disease has been controlled. Good response after only a few days of treatment.

If it is necessary to treat longer, the treatment should not exceed 2 weeks and the total dose should not exceed 50 g/week if not re -examination of the disease condition for patients because the drug has the ability to inhibit the axis under the hill - the pituitary -thin gland. Short treatments can be used to treat overdoing cases. Lighter steroids should be used for treatment if needed continuous treatment with steroids.

With difficult lesions, especially horny horns, can enhance the anti -inflammatory effect of this drug if necessary, by covering the treatment area with a polythen membrane. In general, overnight cover can bring the expectation. After that, the improvement can be maintained without the need to cover.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? Symptoms should be treated when overdose. Symptoms of acute corticosteroid overdose are often recovered. Treatment of electrolyte imbalance if needed. If the poisoning field is performed, advice slowly corticosteroids.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using PowerCort 15 g , you may experience unwanted effects (ADR).

The unwanted effects are listed below by the Meddra Agency and frequency. The frequency is defined as follows: Very common (≥1/10), common (≥1/100 and Data after circulation:

Infection and parasitic infection

Opportunified infections.

immune system disorders

Hypersensitivity, body rash.

Axial inhibition of the hypothalamus-Kidney (HPA): Cushing manifestation (for example, the full moon, obesity in the center), slow weight gain/growth growth in children, osteoporosis, glaucoma, hyperglycemia/glucose urinary tract, cataract, hypertension, weight gain/obesity, endocardized cortisol levels.

Itching, burning on the spot/Skin pain.

Skin atrophy*, zebra*, capillary dilatation*.

Very rare]

On -site irritation/pain.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

PowerCort 15 g contraindicated in the following cases:

Do not specify using this preparation for children under 12 years old. Also contraindicated for patients sensitive to any ingredients of the drug.

as well as other skin corticosteroids, do not use this preparation to treat red acne, acne, dermatitis around the mouth, viral primary dermatitis (herpes, chickenpox), fungal infections (Candida infection, skin fungus) and bacterial infections.

Be cautious when using

Clobetasol Propionat is a corticosteroid used in the skin with a very strong effect capable of inhibiting hypothalamus axes - pituitary - adrenal gland (HPA) at a dose of 2 g/day. The absorption of the body of corticosteroids used on the skin can cause inhibition of the hypothalamus- the pituitary-renal gland recovers, the manifestations of the Cushing syndrome, the hyperlemen blood glucose and theuria glucose in some patients.

Conditions to increase the absorption of the whole body of corticosteroids used on the skin, including strong effects, are large topical area, long -term use and topical tape. Therefore, patients with large-dose skin-doser-doser skin that have a strong effect on a large skin area must be periodically evaluated for manifestations of axial inhibitor-in-axis-yen-nephrotic (HPA) by testing free cortisol in urine and ACTH stimulation tests.

If you find signs of inhibition of axis in the hypothalamus- the pitiful gland (HPA), you should stop the drug, or reduce the frequency of use, or replace it with a steroid that has a weaker effect. The recovery of the HPA axis will generally occur quickly and completely after stopping the medication. The manifestations and symptoms of steroid stops require adding systemic corticosteroids that may occur but not regular.

If applied to the eyelids, be careful to keep the wireless drug in the eye because it can cause glaucoma.

If you see irritation, stop immediately corticosteroids and replace it with an appropriate therapy.

If skin infections are available, appropriate antifungal and antibacterial drugs are needed. If there is no positive response, immediately stop using corticosteroids until the infection is controlled.

Infections will be easily developed in moist and warm conditions caused by ice. Need to wash the damaged area before changing the new bandage.

Some areas of the body such as face, groin, armpits are more likely to shrink than other areas of the body after treatment with local corticosteroids. Regular monitoring of patients is important when treating in these areas.

The ability to drive and operate machinery

Clobetasol Propionate does not affect the ability to drive and operate the machine.

Pregnancy

Group pregnancy classification

Local corticosteroids, especially strong effects, are not used on large skin, in large quantities, or for a long period for pregnant or pregnant women. There is no adequate and good control of the likelihood of monsters in pregnant women. Therefore, PowerCort should only be used for pregnant women if the benefits are greater than the potential risk for the fetus.

The period of breastfeeding

I don't know if topical corticosteroids will go into breast milk. Therefore, be careful when using PowerCort for breastfeeding women.

Drug interaction

Simultaneous drugs that are capable of inhibiting CYP3A4 (eg ritonavir and iTraconazole) have been shown to reduce the metabolism of corticosteroids, resulting in increased body contact. The clinical level of this interaction depends on the dose and sugar of corticosteroids and the effect of CYP3 A4 inhibitors.

Storage

Store at temperatures below 30 ° C. Avoid light.

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