Poziats 5mg Medisun treat schizophrenia, treat acute bipolar disorders (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Aripiprazole

Ingredient

Composition informationContent
Aripiprazole5mg

Uses

Indications

Aripiprazol is a typical anti -psychotic drug that is indicated in the following cases:

  • Treatment of schizophrenia;

    Aripiprazol has high affinity with Dopamine D2 and D3 receptors, Serotonin 5-HT1A and 5-HT2A; Having average affinity with Dopamine D4 receptors, Serotonin 5-HT2C and 5HT7, Alpha1-Aadrenergic and H1 histamine, and has a moderate affinity for Serotonin Restrain Channel.

    The mechanism of action of Aripiprazol has not been clarified, but the effect can be explained through a combination of two properties: partial antagonism at Dopamine D2 and Serotonin 5-HT1A and 5-HT2A receptors.

    Dynamic pharmacokinetics

    Aripiprazol absorbed well, the peak concentration in plasma is within 3-5 hours, bioavailability is 87%. Integrated with serum protein more than 99%, mainly with albumin. Aripiprazol is metabolized mainly by 3 biological transformations: reducing hydrogen, hydroxylation and reducing N-alkyl. The half -life of Aripiprazol is about 75 hours.

    • Before taking Poziats 5mg Medisun treat schizophrenia, treat acute bipolar disorders (3 blisters x 10 tablets)

    How to use

    Aripiprazol is taken once a day and the time of drinking does not depend on the meal.

    Dosage

    schizophrenia

    Adults

    Starting dose and the recommended destination dose is from 10 - 15 mg/day, once used.

    Aripiprazol is effective at 10 - 30 mg/day, but the dose is 10 - 15 mg/day higher than the dose. Do not increase the dose 2 weeks before this is the time it takes to achieve a stable state.

    Maintain treatment

    There is no exact data on the use of long -term Aripiprazol, systematically assessing the schizophrenic patient has stabilized symptoms with other anti -psychotic drugs for a period of ≥3 months and has stopped those drugs, then uses Aripiprazol 15 mg/day and has been monitored recurrence for 26 weeks, showing that the maintenance treatment is 15 mg/day. It is necessary to periodically reassess to determine the maintenance dose.

    Youth

    The recommended target dose of Aripiprazol is 10 mg/day.

    Aripiprazol has been studied in minor schizophrenia from 13 to 17 years of age between 10 mg/day to 30 mg/day.

    Starting dose of 2 mg/day, increasing to 5 mg/day after 2 days and using the target dose 10 mg/day after the next 2 days.

    The dose of 30 mg/day has not been shown to be more effective than the dose of 10 mg/day. Patients should be periodically re -evaluated to determine maintenance dose.

    Conversion from other anti -psychotic drugs

    Not yet collected accurate data in schizophrenia patients who have taken other mental medication and switch to Aripiprazol or use Aripiprazol in combination with other mental drugs. The sudden stopping of mental illness used earlier, although it can be accepted in some schizophrenia patients, but for other patients, the stopped slowly may be more appropriate. In all cases, the intersection between drugs should be reduced to a minimum.

    bipolar disorder

    Adults

    The recommended starting dose in adults is 15 mg/day when used for monomers and 10 mg to 15 mg/day when treatment in combination with lithium or valproat.The recommended target dose is 15 mg/day, when used for monomers or supplementary therapy with lithium or valproat.

    The dose may increase to 30 mg/day based on clinical response. The safety of the dose is over 30 mg/day has not been assessed in clinical trials.

    Youth

    The recommended starting dose in teenagers (from 10 to 17 years old) with a single therapy is 2 mg/day, increasing the dose to 5 mg/day after 2 days, and increasing to the dose of 10 mg/day after the next 2 days.

    The recommended dose does not change when using supplementary therapy with lithium or valproat.

    If necessary, the dose can increase by 5 mg/day, but it is necessary to increase the dose slowly, within a minimum period of 1 week to increase the dose once. Patients should be periodically evaluated to determine the maintenance dose of treatment.

    Treatment of depression support - in collaboration with other depression treatments

    Adults

    The initial starting dose is recommended for supplementary treatment for patients with depression disorders taking antidepressants from 2 to 5 mg/day.

    The recommended dose is from 2 to 15 mg/day.

    If necessary, the dose can increase by 5 mg/day, but it is necessary to increase the dose slowly, within a minimum period of 1 week to increase the dose once. Patients should be periodically evaluated to determine the maintenance dose of treatment.

    Autism disorders

    Children and teenagers (from 6 to 17 years old)

    Dosage range is recommended from 5 to 15 mg/day.

    Starting dose of 2 mg/day. Increase the dose to 5 mg/day, then increase to 10 or 15 mg/day if necessary.

    If necessary, the dose can increase by 5 mg/day, but it is necessary to increase the dose slowly, within a minimum period of 1 week to increase the dose once. Patients should be periodically evaluated to determine the maintenance dose of treatment.

    Tourette syndrome

    Children and teenagers (from 6 to 18 years old)

    Doses recommended for treatment of tourette syndrome from 5 to 20 mg/day.

    For patients weighing less than 50 kg, the starting dose of 2 mg/day, an increase of 5 mg/day after 2 days. It may increase to a dose of 10 mg/day in patients who do not achieve optimal control. However, it is necessary to increase the dose slowly, within a minimum period of 1 week to increase the dose once.

    For patients weighing 50 kg or more, the starting dose of 2 mg/day for 2 days, and then increasing to 5 mg/day for 5 days, the 8th day is used by 10 mg/day.

    The dose may increase to 20 mg/day for patients who do not achieve optimal control. If needed, the dose increases by 5 mg/day, but it is necessary to increase the dose slowly, within a minimum period of 1 week to increase the dose once. Patients should be periodically evaluated to determine the maintenance dose of treatment.

    When used with other drugs that cause interaction, Aripiprazol is recommended to adjust the dose.

    What to do when overdose?

    When an overdose, early use of activated carbon or dialysis can reduce the absorption of Aripiprazol. Besides, the ECG measurement should be conducted, measures to maintain respiratory function and symptomatic treatment.

    What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

    Side Effects

    When using Poziats 5 mg, you may experience unwanted effects (ADR).

    Common, ADR> 1/100:

  • Systemic: influenza syndrome, neck pain, pelvic pain, chest pain, stubborn neck, stubbornness.

    • Cardiovascular: tachycardia, hypotension, slow heart rate. digestion: Nausea, vomiting.

  • Blood and lymphatic system: Anemia.
  • Metabolic/nutrition disorders: weight loss, increased creatin - phosphokinase, dehydration.
  • Nervous system: depression, agitation, abnormal gait, manic reaction, schizophrenic mental reaction, hallucinations, suicide ideas, opposition, confusion, paranoid reaction.
  • Respiratory: Sinusitis, shortness of breath, pneumonia, asthma.

    • Uncommon, 1/1000

  • Body: Facial edema, suicide thought, migraine, feeling of stiffness (in the abdomen, jaw, neck, tongue, chest, back, head, head), chills, light sensitivity, jaw pain, sore throat, abdominal, stomach, chest tightness.
    • Cardiovascular: Brushing chest drum, bleeding, heart failure, myocardial infarction. Digestive: Increasing cravings, swallowing difficulties, gastritis - intestines.
  • Endocrine: Hypothyroidism.
  • Blood and lymphatic system: Radyto anemia, leukopenia, leukopenia.

    • Metabolic/nutritional disorders: edema, hyperglycemia, hypercholesterol.

    Nervous system: distracting, erratic emotions, convulsions, spasms. Respiratory: pneumonia, nosebleeds, hiccups, laryngitis.

    Rare, 1/10000

  • Systemic: Heavy head, stroke, throat swelling, Mendelson syndrome.
    • Cardiovascular: Aura, heart failure, big heart, thrombosis.
  • digestive: esophagitis, gastrointestinal ulcers, vomiting blood, gut, bleeding.
  • Endocrine: goiter, hyperthyroidism.
    • blood and lymphatic system: Bleeding spots, platelets, platelets.
  • Metabolic disorders/nutrition: Animal inflammation, rheumatoid arthritis, muscle pattern, hepatitis.
  • Nervous system: Reduce tone, loss of regulation of movements, increased longevity.
    • Respiratory: dry nose, pulmonary edema, increased secretion of phlegm, pulmonary embolism, oxygen deficiency.

    Instructions on how to handle ADR

    When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

    Warnings

    Before using the drug you need to read the instructions carefully and refer to the information below.

    Contraindicated

    Poziats against contraindications in cases of hypersensitivity to any ingredients of the drug.

    Caution when using

    Attention: Preventive attention: Malignant sedative syndrome, movement disorders.

    Precautions at use: Hypotension posture, epilepsy, cognitive impairment and exercise, reducing the ability to regulate body temperature, difficulty swallowing, suicide.

    Used in other patients with other diseases: Elderly patients with psychosis with Alzheimer disease.

    The ability to drive and operate machinery

    Side and drowsiness side effects affect the ability to drive and operate machinery. So do not use the drug when driving and operating machinery.

    pregnancy

    azipiprazol should not be used for pregnant women unless the maternal benefits are more pronounced the potential risks for the fetus.

    Breastfeeding period

    Aripiprazol excreted in milk, should not be used for nursing mothers.

    Drug interaction

    Aripiprazol works mainly on the central nervous system, so be careful while coordinating Aripiprazol with alcohol and drugs that affect the central nervous system.

    Aripiprazol has an antagonistic effect on the alpha1-adrenergic receptor, thus capable of increasing the effects of some anti-hypertension drugs.

    CYP3A4 induction substances (such as carbamazepin) can increase Aripiprazol excretion, CYP3A4 inhibitors (such as ketoconazol) or CYP2D6 inhibitors (such as Quinidin, Fluoxetin or Paroxetin) can inhibit the elimination of Aripiprazol and cause an increase in Aripiprazole in the blood.

    Storage

    Store in a dry place, avoid light, temperature below 30 ° C.

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