Pracetam 400 Stella tablets treat dizziness, memory impairment (10 blisters x 10 tablets)

Many of these substances are considered to have a stronger effect on piracetam in terms of learning and memory. It is thought that in both ordinary people and people with impaired function, Piracetam works directly to the brain to increase the activity of the brain area (the brain area is involved in the mechanism of awareness, learning, memory, alertness and consciousness).

Piracetam acts on some neurotransmitters such as acetylcholin, noradrenalin, dopamine ... This can explain the positive effect of the drug on learning and improve the ability to perform memory tests. The drug can change neurotransmitter and contribute to improving the metabolic environment for good neurons to work well.

On experiments, Piracetam has a protective effect against metabolic disorders due to ischemia by increasing brain resistance to oxygen deficiency.

Piracetam increases the mobilization and use of glucose without depending on the supply of oxygen, facilitates the pentose path and maintains energy synthesis in the brain.

Piracetam enhances the recovery rate after damage due to lack of oxygen by increasing the rotation of inorganic phosphate and reducing glucose and lactic acid accumulation.

Under normal conditions as well as when oxygen deficiency, Piracetam is found to increase the amount of ATP in the brain due to increased ADP conversion to ATP; This may be a mechanism to explain some useful effects of the drug.

The impact on acetylcholin transmission (increasing the release of acetylcholin) may also contribute to the mechanism of action of the drug. The drug also has the effect of increasing the release of dopamine and this can work well on the formation of memory.

The drug has no effect on sleep, sedation, resuscitation, pain, nerve or neuron and no effect of GABA.

Piracetam reduces the ability to converge platelet and in case of abnormal erythrocytes, the drug can cause red blood cells to restore deformation and ability to pass through capillaries. The drug has anti -vibration effect.

pharmacokinetic

absorption

After drinking, Piracetam is absorbed quickly and almost completely through the intestine. Birth is about 100%. When taking a single dose of 2 g, the peak concentration in the blood reaches 40 - 60 mcg/ml after 30 minutes. The peak concentration in cerebrospinal fluid is achieved after taking the drug 2 - 8 hours.

Volume distribution is about 0.6 l/kg. The semi -discharged time in plasma is 4-5 hours, while the sale time in cerebrospinal fluid is 6-8 hours. The selling time increases in the case of renal failure.

Distribution - Metabolism

Piracetam is not associated with plasma proteins and is excreted mainly through the kidneys in the form of air.

Piracetam diffuses all types of tissues and can be through both blood and placenta barriers, as well as membranes used in the kidney.

piracetam is active in intact and not metabolized in any animal that has been tested.

Piracetam is concentrated in the cerebral cortex, lobes of forehead, lobes and occipital lobes, cerebellum and base core.

Elimination

The excretion through the kidney is almost completely,> 95% after 30 hours. Piracetam's kidney clearance coefficient in healthy people is 86 ml/min.

What to do when overdose?

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Caution when using

Because piracetam is metabolized mainly through the kidneys, need to be cautious when treating patients with renal failure. Monitor kidney function in these cases. The increase in the semi -emissions time is directly related to the impaired renal function and creatinine clearance. This is also true for elderly patients whose creatinine clearance depends on age.

Due to the impact of Piracetam on plateletic collection, be careful in patients with severe bleeding, patients are at risk of bleeding such as gastrointestinal ulcers, patients who are suffering from hemostasis disorders, patients with a history of hemorrhage due to bleeding, patients undergo surgery including tooth surgery and patients taking anticoagulants or anti -platelets including low dose Aspirin.

Avoid sudden treatment in muscle vibration patients because this can cause an outbreak or epilepsy due to drug stops.

The ability to drive and operate machinery

In clinical studies, at the dose of 1.6 - 15 g/day, hyperactivity, sleep, restlessness and depression are reported more frequently in patients using piracetam than patients using Placbo.

There is no experience on the effect of driving at the dose of 15 - 20 g/day. Therefore, patients should be cautious when intending to drive or operate machinery while using piracetam.

Pregnancy

piracetam through the placenta. Piracetam should not be used during pregnancy.

Breastfeeding period

piracetam is secreted through breast milk. Therefore, piracetam should not be used during breastfeeding or breastfeeding while being treated with piracetam.

Medicine interaction

can still continue the method of treating classic alcoholism such as vitamins and sedatives, in the case of patients who are missing vitamin or excited.

A case of interaction between piracetam and thyroid essence (T3 and T4) when used simultaneously: confused, easily agitated and sleep disorders are replaced later.

Piracetam increases prothrombin time in patients who have been stabilized by warfarin .