Praxilene 200mg Merck Treatment Treatment of chronic obstructive arteritis (2 blisters x 10 tablets)

Dosage form Box of 2 blisters x 10 tablets
Specifications Naftidrofuryl oxalate

Ingredient

Composition information	Content
Naftidrofuryl oxalate	200mg

Uses

Indications

Praxilene 200mg drug is indicated for use in cases of painful pain treatment due to chronic peripheral artery disease of the lower limb (phase II).

Pharmacokology

Naftidrofuryl produces two synergistic effects, leading to spreading ischemic effect.

At the blood vessel level: as a specific antagonist of receptors 5-HT2, Naftidrofuryl against vascular shrinkage and platelet collection of serotonin.

At the cell level: As an active substance producing ATP, Naftidrofuryl enhances the metabolism of ischemic cells.

Clinical effectiveness

In Phase II, peripheral artery disease significantly increases the walking distance on the rug compared to the placebo.

In a clinical study on patients with anhuman pain, observing improvement and intensity and frequency of pain during exertion and improvement of daily activities.

pharmacokinetic

absorption

Rapid absorption in the intestine: The plasma peak concentrations are achieved within 2.5 hours after taking the drug.

Distribution

The ratio attached to plasma protein is 80%. Naftidrofuryl passes through the bloody barrier and can be through the placenta.

Metabolism

Naftidrofuryl is metabolized, mainly due to hydrolysis, into other inactive metabolites.

Elimination

80% is excreted in urine in the form of metabolites, mainly in combination form. Selling time is about 3 to 4 hours.

Before taking Praxilene 200mg Merck Treatment Treatment of chronic obstructive arteritis (2 blisters x 10 tablets)

How to use

Praxilene 200mg is used orally. Take medicine at meals. Swallowing the tablet without chewing and drinking with 1 cup of large water.

Dosage

The peripheral artery disease of the lower limbs: 3 times a day, 1 tablet each time, equivalent to 600mg of Naftidrofuryl/day.

Treatment with Naftidrofuryl only works on symptoms that allows a moderate improvement to walk the walking distance for 6 months after the beginning of treatment. It should only be used as a support for other treatments or proposed methods for treatment in the second phase of chronic peripheral artery disease (such as control of cardiovascular risk factors, regular exercise, stop smoking).

Should re -evaluate the response to treatment after 6 months and to reconsider the decision to continue treating in the absence of improvement.

Older people

This drug is mainly used for the elderly. Old age does not appear to affect the pharmacokinetic properties of oral Naftidrofuryl. Therefore, it is not necessary to adjust the dose of Naftidrofuryl for this object.

Children

This drug is not prescribed for children.

What to do when overdose?

Treatment should be gastrointestinal, can use activated carbon if necessary, should monitor cardiovascular functions and symptomatic treatment. Controlled convulsions by diazepam.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using praxilene 200mg, you may experience unwanted effects (ADR).

Gastrointestinal disorders

Not usually: diarrhea, nausea, vomiting and epigastric pain.

Unknown: In some patients who take medicine without drinking water before going to bed, the pill is stuck in the neck causing esophagitis on the spot.

There are cases where the oral mucosa has been reported.

Kidney and urinary disorders

Very rare: calcium oxalate kidney stones.

Skin and tissue disorders.

Not usually: rash.

Liver disorders

Rare: liver damage. There are cases of serious liver damage to the type of acute cell pepper that has been reported.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Praxilene 200mg drug is contraindicated in the following cases:

Hypersensitivity to Naftidrofuryl or any ingredients of the drug.

Caution when using

This medication can change the composition of urine, promote the formation of calcium oxalate kidney stones.

Oxalate content in 1 tablet of 200mg is 38mg. Therefore, drink enough water during treatment to maintain enough urine. Taking this medicine before going to bed without drinking water will cause esophagitis on the spot. Therefore, it is necessary to always take praxilene 200mg with 1 large glass of water.

Cases of serious liver damage The type of acute cell pepper has been reported. In case of suspicion, liver damage must check the concentration of transaminase. The drug should be stopped if the symptoms suggest liver damage occurs and if there is an increase in transaminase level, even if the increase is moderate.

Naftidrofauryl is not a medication to treat hypertension.

Do praxilene 200mg contains lactose, contraindicated in the case of congenital hematoma galactose, glucose -galactose absorption syndrome or in the case of lactase deficiency.

The ability to drive and operate machinery

Naftidrofuryl does not affect the ability to drive or operate machinery.

Pregnancy

This drug is mainly used in the elderly no longer at risk due to pregnancy. Due to the lack of clinical data related, people do not recommend Naftidrofuryl during pregnancy.

Breastfeeding period

This drug is mainly used in the elderly. Due to the lack of clinical data related, people do not recommend Naftidrofuryl during breastfeeding.

Drug interaction

Unknown drug interactions. To avoid interactions that may occur with other drugs, it is necessary to report to your doctor or pharmacist whatever medicine you are taking during use.

Storage

Store at temperatures below 30 ° C.

To be out of reach of children.

Other drugs

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