Prednisolon Boston treats inflammatory and allergic disorders (200 tablets)

Dosage form Bottle of 200 capsules
Specifications Prednisolone

Ingredient

Composition information	Content
Prednisolone	5mg

Uses

indications

Prednisolon are indicated in the treatment of inflammatory and allergic disorders.

Pharmacological

Prednisolon is a glucocorticoid that has a clear anti -inflammatory, anti -allergy and immunosuppressive effect.

Basic corticosteroidal anti -inflammatory ability is shown by the mechanisms:

Inhibits leukocytes and macrophages, preventing their movement into the inflamed area. Related.

Prednisolon is easily absorbed through the gastrointestinal tract and exists in the form of active metabolites.

Prednisolon's absorption ability is affected by food.

Distribution

Plasma peak concentration reaches 1-2 hours after taking the drug. Prednisolon is strongly connected to plasma proteins, although less than hydrocortison. Prednisolon passes the placenta and a small amount is excreted through breast milk.

Metabolism

Prednisolon is metabolized in the liver. Selling time for 2-4 hours.

Elimination

Prednisolon is excreted in the urine in the form of ester sulfate and glucuronid along with large amounts in the form of unchanged Prednisolon.

Before taking Prednisolon Boston treats inflammatory and allergic disorders (200 tablets)

How to use

use Prednisolon after eating.

The lowest doses that are effective should be used in the shortest time to reduce side effects.

Dosage

adults

Starting dose: 5 to 60 mg/day, taking 1 single dose in the morning, or using Japanese insulation. Oral medication after eating. The dose may be reduced within a few days but if needed for a few weeks or months.

Maintenance dose: 2.5 to 15 mg/day. Cushing syndrome may be suffered from> 7.5 mg/day if used for a long time.

Children

Only used in specific specified cases with minimum doses in the shortest possible time:

Anti-inflammatory and immunosuppressive inhibition: 0.1-2 mg/kg/day, divided into 1-4 times.

Genital bronchial asthma: 1-2 mg/kg/day, divided into 1-2 times (maximum 60 mg/day), for 3-10 days. Prolonged treatment: 0.25 - 2 mg/kg/day, drink once a day in the morning or daily when needed to control asthma.

Nephrotic syndrome: Starting 2 mg/kg/day or 60 mg/m2/day (maximum 80mg/day), divided into 1-3 times, until urine is no longer protein for 3 consecutive days or for 4-6 weeks. Then, use the maintenance dose of 1 - 2mg/kg or 40 mg/m, used on the morning in the morning for 4 weeks. Maintain long term if frequent recurrence: 0.5 -1.0 mg/kg, used for daily for 3-6 months.

What to do when overdose?

Handling: There is no specific antidote. Symptomatic treatment is considered in this case. Need to monitor electrolytes in serum if the case occurs overdose.

What to do when forgetting the dose? If the next dose time, skip the forgotten dose and take the next dose. Do not use 1 time 2 dose.

Side Effects

When using Prednisolon drugs often experience unwanted effects (ADR) such as:

Inhibition of hypothalamus - pituitary - adrenal ads for dosage, time of use and treatment time.

Endocrine and metabolism, inhibiting the axis of the hypothalamus-Yen-Than Kidney, inhibiting growth during the embryo, childhood and childhood, abnormal menstrual periods and amenorrhea. Hairy, weight gain, reducing carbohydrate tolerance, hyperglycemia, pre -diabetes. Loss of calcium, increase appetite. Hyper cholesterol and triglyceride increased. High or long -term doses of corticosteroids can cause Cushing syndrome.

Anti -inflammatory and immunosuppressive effects: Increasing sensitivity and severity of infection along with concealing signs and clinical symptoms: opportunistic infections, recurrent tuberculosis.

muscle weakness, osteoporosis, fracture. Visual necrosis is associated with long -term treatment or high doses of corticosteroids.

Keeping water and sodium, electrolyte disorders, potassium loss, alkaline infection, hypokalemia, edema.

Disorders of blood and lymphatic systems, hyper coagulation.

vascular disorders, hypertension.

A series of mental reactions such as emotional disorders (stimuli, excitement, depression and unstable mood, suicide thought), paranoia, hallucinations, schizophrenia, behavioral disorders, irritability, anxiety, sleep disorders.

Increased internal pressure compared to gai in children, usually after sudden treatment.

Surgery: increased the pressure of eyeball, glaucoma, thorny gai, cataract. Long -term use of corticosteroids can cause eye convex.

Digestive: digestive disorders, stomach ulcers with perforation and hemorrhage, acute pancreatitis, Candida infection, nausea.

Dermatology: Skin atrophy, bruising, acne, thin skin, blushing.

Hypersensitivity includes anaphylactic reaction, which has been reported. Leukemia. Venous thrombosis, recent heart muscle rupture, increased risk of Stevens-Johnson syndrome or poisoned epidermal necrosis, tumor explanation syndrome.

Sudden stopping after prolonged corticosteroid dose can lead to acute adrenal failure, lower blood pressure and death. Detox syndrome "may also occur including fever, muscle pain, muscle weakness, joint pain, rhinitis, conjunctivitis, weight loss, mental change, emotional changes, nausea, vomiting, hypotension, benign intracranial hypertension, dizziness, headache, and re -appear of symptoms.

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Contraindications for treatment with Prednisolon in the following cases:

Hypersensitivity to Prednisolon or any ingredient of the drug.

Caution when used

Before treatment with glucocorticoid for a long time, the electrocardiogram, blood pressure, lung and spine X-ray, test glucose tolerance and assess the hypothalamus function-pituitary-adrenal gland (HPA) for all patients. Prednisolon can cause adrenal energy or HPA axis inhibitors, especially in children and patients taking high doses for a long time. For long -term use for many years may have adrenal atrophy after stopping treatment. Therefore, the lowest dose is effective in the shortest time to reduce side effects.

Be cautious and reduce the dose slowly in patients who are not at risk of recurrence and belong to one of the following groups of patients:

Adults: take a dose greater than 40 mg/day (or equivalent) for more than 1 week. The dose of 1 mg/kg for 1 month. Kidney.

Systemic corticosteroids can be stopped suddenly in patients who are not at risk of recurrence and those who have a 3 -week treatment period and do not belong to one of the above patients.

There are 2 complications that require immediately stop or decrease to the physiological dosage while being treated with corticosteroids:

Acute mental disorders caused by corticosteroids when not responding to anti -psychotic drugs.

While Ingung treatment can reduce the dose quickly with physiological doses (equivalent to 7.5 mg of prednisolon daily) and then reduce the dose slowly. Assessing the condition is necessary in the process of stopping the drug to ensure the risk of recurrence does not occur.

Patients who are about to have surgery may have to use glucocorticoid supplements because of the normal response to stress that has been reduced due to the inhibition of hypothalamus - pituitary - adrenal glands.

Corticosteroid high doses can cause acute muscle disease, common in patients with neurotransmitter disorders, can be seen in the eye and/or respiratory muscles. Creatin kinase must be monitored. Using corticosteroids can cause mental disorders, including inhibition, refreshment, insomnia, mood and personality change. Can worsen the existing mental disorders.The prolonged corticosteroid use may increase secondary infections, covering acute infections (including fungal infections), prolonged or severe viral infection, or reduced response to vaccines.

Do not use the treatment of herpes simplex in the eyes, brain malaria or viral hepatitis.

Tightly monitor patients with potential tuberculosis and/or have a TB reaction. Used limited in operating tuberculosis, only used when combined with anti -tuberculosis drugs.

The prolonged corticosteroid use can cause glaucoma, optic nerve damage (not indicated for treatment of optic neuritis), blurred vision and market reduction, cataracts under the following bags. Used after glass surgery can slow down the incision or increase bleeding.

There has been a prolonged treatment report with corticosteroids that develops Sarcom Kaposi, consider stopping treatment.

Use cautiously in patients with thyroid disease, liver failure, kidney failure, cardiovascular disease, diabetes, glaucoma, cataract, muscle weakness, risk of osteoporosis, risk of convulsions or digestive tract disease (cholecystitis, stomach ulcers, duodenal ulcers, colon ulcers). Use caution after acute myocardial infarction.

Children: Corticosteroids slow growth and development in children, therefore, need to be cautious and regularly monitor when using prolonged prednisolon.

Elderly: Common side effects of systemic corticosteroids are often more serious in the elderly, especially osteoporosis, hypertension, hypokalemia, diabetes, sensitive to infections and thin skin. Clinical monitoring is necessary to avoid life threats.

In the composition containing lactose may not be suitable for patients with lactose intolerance, galactosaemia disease or malcose/galactose malabsorption.

affects the ability to drive and operate machinery

No report information.

Women during pregnancy and lactation

Pregnant women

Prednisolon passes the placenta and can be dangerous to the fetus when used in pregnant women. Animal studies and people suggest that using corticosteroids in the first 3 months of pregnancy increases the risk of lip chipping, cleft palate, reducing pregnancy growth in the uterus and reducing weight at birth. Using corticosteroids for mothers during pregnancy can cause adrenal insects in newborns.

If using Prednisolon during pregnancy or starting to get pregnant while taking medication, health workers must notify patients in advance the danger to the fetus. In general, using corticosteroids in pregnant women requires consideration of benefits that can be achieved compared to the risks that may occur with mother and child.

breastfeeding women

Prednisolon secretes breast milk with a concentration of milk in 5-25% of serum concentration, about 0.14% of the mother's daily dose. Be careful when using prenisolon for nursing women. Mothers taking high doses of corticosteroids for a long time can affect the growth and development of breastfed babies and affect endogenous corticosteroid production. Must consider benefits/risks for both mother and child.

If forced to use Prednisolon for nursing women, the lowest dose must be used enough to achieve clinical effect.

Drug interaction

Avoid coordination: Avoid simultaneous use of Prednisolon with Natalizumab, live vaccines.

Increase toxic effects:

Prednisolon may increase the effects of: acetylcholinininiserase inhibitors, amphotericin B, cyclosporin, strap diuretics, thiazid diuretics, natalizumab, nonsteroidal anti -inflammatory drugs (non -selective COX inhibitors and COX 2 selective inhibitors), live vaccines, wafarin.

Medications that increase the concentration or effect of prednisolon: antifungal drugs (Azol group derivatives use systemic sugar) ,prepitant, calcium channel blockers (not belonging to dihydropyridin), cyclosporin, estrogen derivatives, fluconazol, fosaprepitant, macrolid group antibiotics, non -reducing inhibitors (non -reducing inhibitors) Antibiotics of Quinolon group, trastuzumab, ritonovir.

Reduce effect:

Prednisolon can reduce the concentration/effect of: anti -diabetes drugs, calcitriol, corticorelin, isoniazid, saliylates, vaccines (inactivated), somatropin. The effect of Prednisolon can be reduced by: aminoglutethimid, antacids, barbiturates, bile acid, echinacea, primidon, rifamicin derivatives, phenytoin, carbamazepin.

Parenture stimulants (Bambuterol, Salbutamol, Salmeterol, Terbutalin ...): Increased risk of hypokalemia if using high doses of corticod.

Using the same digitalis may increase the risk of hypotension due to hypokalemia.

Must monitor tightly when taking the same drugs also reduces potassium.

Prednisolon can cause hyperlem of blood glucose, so it is necessary to adjust the anti -diabetic dose. Avoid simultaneous use of precednisolon with nonsteroidal anti -inflammatory drugs because it can cause stomach ulcers.

Other drugs: The desired effect of hypoglycemic drugs (including insulin), anti -hypertension drugs, antagonistic diuretics by corticosteroids and worsen the risk of acetazolamide hypotension, strap diuretics, thiazid diuretics, carbenoxolon, theophylllin.

Interaction with herbal alcohol:

alcohol: Avoid alcohol (because it may increase the irritation of the stomach lining).

Food: Prednisolon affects calcium absorption. Restricting caffeine.

Storage

Where dry, less than 30 ° C, avoid light.

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