Prednisolon Sachet 5mg Vacopharm anti -inflammatory, anti -allergy (30 packs x 1g)

Dosage form 30 package box
Specifications Prednisolone

Ingredient

Composition information	Content
Prednisolone	5mg

Uses

indications

Prednisolon Sachet drug is indicated when it is necessary to anti -inflammatory, anti -allergic and immunosuppressive effects:

allergies: Severe allergies: Allergic dermatitis, Hypersensitivity reactions, seasonal or year-round allergic rhinitis, serum. Calculating, granulomatitis (semi -acute, no pus), primary or secondary adrenal insufficiency (hydrocortison or cortison is the top choice, synthetic drugs can be used in combination with mineralocorticoid). Diamond-Blackfan, spontaneous platelet hemorrhage in adults, anemia, secondary thrombocytopenia in adults. Cerebral edema in primary brain tumors or metastatic, opening tricks or head damage. Aspergillus fungal disease- allergic lungs; pneumonia due to inhalation of substances; bronchial asthma; tuberculosis outbreaks or spread when used simultaneously with appropriate chemotherapy; Hypersensitivity pneumonia; Sumonaritis is blocked by spontaneous pneumonia, spontaneous eosin pneumonia; Spontous pulmonary fibrosis, pneumocystis carinii (PCP) pneumonia with hypoxemia in HIV patients (+) are being treated with appropriate antibiotic PCP; Sarcoid disease. In severe phase or maintenance treatment in certain cases (selected) of joint spondylitis, dermatitis/ muscle dermatitis, low muscle pain, temporal arthritis, psoriasis arthritis, recurrent cartilage inflammation, rheumatoid arthritis, including teenage rheumatoid arthritis (some cases need low doses for maintenance treatment), siogrenic sioge syndrome, lupus. Special infections: Worm disease in the nervous system or myocardial, meningitis due to tuberculosis average to severe (must be used simultaneously with appropriate anti -tuberculosis chemotherapy). glucocorticoid.

ATC code: H02AB06, R01AD02.

Prednisolon is a synthetic adrenal steroid with the main characteristics of a glucocorticoid. Some of these characteristics produce the physiological effects of endogenous glucocorticoids. The effects of Prednisolon are due to glucocorticoid characteristics include: increasing glycogen synthesis, increasing glycogen storage in the liver, inhibiting the use of glucose, antagonistic antagonism of insulin, increasing protein catabolic leads to negative nitrogen balance, redistribution of fat in the body, increasing lipid cancellation, increasing glomerular filtration speed leading to urine excretion in urine exchange), reduce calcium absorption in the intestine and increase the excretion of calcium through the kidneys. Prednisolon reduces acid and lymphocytes but stimulates red blood cells in the bone marrow and neutrophils. In physiological doses, corticosteroids are used to replace endogenous hormones.

Other effects of glucocorticoids are only available when using higher doses of treatment than physiological doses (pharmacological doses). In these doses, the drug is used for both treatment and diagnostic purposes, due to the ability to inhibit the normal excretion of adrenal hormones. In pharmacius doses, glucocorticoids have anti -inflammatory, immunosuppressive effects and effect on blood and lymphocytes, used for temporary treatment in many different diseases.

Prednisolon inhibits inflammation (edema, fibrin deposits, capillary dilatation, leukocytes and macrophages into inflammatory foci) and the later stage of healing wound healing (hyperplasia, collagen deposition, scar formation). Anti -inflammatory mechanism: Stabilizing lysosom membrane of leukemia, preventing the release of acid hydrolase destroyed from leukocytes, inhibiting concentration of macrophages at inflammatory drive, reducing leukocytes with capillary endothelium, reducing vascular permeability and edema formation, reducing complex components, antagonism with the activity of histamine and releasing kinine, reducing the fiber biochemical, unprocessedness of the fiber, and the scars of the fiber, and the scars in the stage, the fibrous sediment is in the next stage of the fiber Know well.

Prednisolon inhibits the immune system due to reducing the activity and volume of the lymphatic system, reducing lymphocytes, reducing immune globulin and complementary concentrations, reducing immune complexes through membranes and can be by reducing tissue reactions to antigen -antibodies.

Prednisolon can stimulate the excretion of different components of gastric juice. Prednisolon has weak mineralocorticoid activity, increases sodium retention and loss of potassium in the cell, can lead to sodium stagnation and hypertension.

Glucocorticoid therapy does not cure the disease and is rarely indicated as the first method in treatment, usually for supportive treatment with other specified therapies.

Effects of oral Prednisolon compared to other glucocorticoids: 5mg Prednisolon has the same effect as 4mg of methylprednisolon or triamcinolon, 0.75mg dexamethasone, 0.6mg betamethasone and 20mg hydrocortison.

Dynamic pharmacokinetics

Prednisolon is easily absorbed from the digestive tract, bioavailability depends on the solubility speed if taking the tablet. The peak concentration in plasma is achieved from 1-2 hours after drinking. Prednisolon binds to protein about 65-91%, reduced in the elderly. The distribution of the drug is 0.22-0.7 liters/kg.

Prednisolon is metabolized mainly in the liver, but is also metabolized in most tissues, into non -activity metabolites. Elimination mainly in urine in the form of free metabolites or sulfate and complex glucuronid. Prednisolon waste time is about 3.6 hours. Effect time 18-36 hours.

Before taking Prednisolon Sachet 5mg Vacopharm anti -inflammatory, anti -allergy (30 packs x 1g)

How to use

Dissolve the drug in water to drink.

Dosage

Prednisolon dosage depends on the disease that requires treatment and response of the patient. The dosage for children and children must rely on the condition of the disease and the patient's response rather than the correct way to the instructions for age, weight or body surface area. The dose is calculated according to Prednisolon Base. After achieving the desired response, it is necessary to gradually reduce the dose to the extent that it is still appropriate to maintain the appropriate clinical response. Must constantly monitor patients to adjust the dose when needed.

When stressed while using corticosteroids (surgery, infection, injury) should increase the dose before, during and after stress. If the prednisolon is needed for a long time, it is advisable to consider the medication regimen whenever possible whenever possible, using only once after breakfast, so it will be less inhibited by the hill - the pituitary gland, limiting ADR, but may not achieve adequate control. Continue to try reducing the dose and it is best to completely withdraw glucocorticoid. After long -term treatment must stop Prednisolon gradually.

Take medicine after meals or with food or milk to reduce the effect on the digestive tract. Increase a diet high in pyridoxin, vitamin C, vitamin D, calcium and phosphorus.

Monitor the parameters: blood pressure, blood glucose, electrolytes, eye pressure (when used for more than 6 weeks), bone mineral density.

Children:

Granting asthma: 1-2mg/kg/day, divided into 1-2 times (maximum 60mg/day), for 3 -10 days. Prolonged treatment: 0.25-2mg/kg/day, drink once a day in the morning or daily when needed to control asthma. In 4-6 weeks. Then use the maintenance dose of 1-2mg/kg or 40mg/m², use a day in the morning for 4 weeks.

The usual dose: 5-60mg/day. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? Wounds and bones, headache, weakness, menstrual disorders, more severe menopause, neuropathy, osteoporosis, fracture, stomach -duodenal ulcer, reduced glucose tolerance, hypokalemia and adrenal impairment. Big liver and bloating were met in children.

Extremely overdose treatment: gastric lavage or instant vomiting, then symptomatic treatment and support.

Treatment of chronic overdose in patients with severe illnesses must continue to use steroids, can reduce the temporary dose of prednisolon or rotate the treatment day.

In case of emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose

Side Effects

When using the drug often has unwanted effects (ADR) such as:

ADR is most common when using high -dose and long -doses of prednisolon. Common corticosteroid ADR includes fluid fluid, glucose tolerance, hypertension, mood change and behavior, stimulating delicious food and weight gain.

Prednisolon inhibits prostaglandin synthesis and thus losing the effect of prostaglandin on the gastrointestinal tract, which means losing the effect of inhibiting stomach acid secretion and protecting the stomach lining.

Mental reactions such as stimulation, excitement, depression and unstable mood and suicide thoughts, mental reactions (including paranoia, hallucinations and schizophrenia), behavioral disorders, irritability, anxiety, sleep disorders and cognitive disorders including confusion and memory loss have been reported. The reactions can occur in both adults and children. In adults, the estimated frequency is 5-6%.

Instructions on how to handle ADR:

After a long -term treatment with glucocorticoid, there is a possibility of inhibiting the hypothalamus - pituitary - adrenal gland, so it is imperative to reduce the dose of glucocorticoids step by step, instead of sudden stopping. Prednisolon's dose reduction process may be applied: every 3 to 7 days decrease 2.5-5mg, until the physiological dose of Prednisolon is approximately 5mg. If the disease is worse when it is reduced, increasing the dose of prednisolon and then reducing the prednisolon dose slowly.

Apply continuous treatment to avoid drugs with pharmacological effects. Taking a single dose of the day causes less ADR than using doses of division during the day, and Japanese insulation is the best way to minimize adrenal inhibition and minimize other ADRs. In Japanese therapy, every two days use a single dose, in the morning.

Preventive gastric and duodenal ulcerative prophylaxis with antihistamine H2 or proton pump inhibitors when taking high doses of corticosteroids.

All long -term patients with glucocorticoids need additional calcitonin, calcitriol and supplementing calcium to prevent osteoporosis.

Notify the physician with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Prednisolon Sachet drugs are contraindicated in the following cases:

Hypersensitivity to Prednisolon or any ingredients of the drug. Virus.

Patients with mental disorders.

Be cautious when using

need to be very careful when taking the drug for patients in the following cases:

Patients who do not tolerate Galactose, Lagoon Lactase or Glucose -Galactose should not take this medication. All patients. When stopping the drug must be cautious and slowly reduced. Closely monitor patients who are taking corticosteroids to use inhalation because they may be deficient in hormones or when stopping the drug, including increasing allergic symptoms, especially in Prednisolon users> 20mg/day. Hormones). Creatin kinase must be monitored. Using corticosteroids can cause mental disorders, including inhibition, refreshment, insomnia, mood and personality change. It may worsen the existing mental disorders. Closely monitor patients with potential tuberculosis and/or TB reaction. Used in limited tuberculosis, only used when combined with anti -tuberculosis drugs. Used after lens surgery can slow down the incision or increase bleeding. (excess bags, stomach ulcers, duodenum ulcers, colon ulcers). Use caution after acute myocardial infarction. Do not use in patients with reduced circulation in the skin.

Symptoms usually appear within a few days or weeks after treatment. Most of the reactions will recover after a decrease in the dose or stopping the drug.

The effect of the drug on the ability to drive and operate machinery

Caution when used because the drug can cause dizziness, headache, seizures.

Use drugs for women during pregnancy and lactation

Pregnancy

Prednisolon passes the placenta and can be dangerous to the fetus when used in pregnant women. Animal studies and people suggest that using corticosteroids in the first 3 months of pregnancy increases the risk of lip chipping, cleft palate, reducing pregnancy growth in the uterus and reducing weight at birth. Using corticosteroids for mothers during pregnancy can cause adrenal insects in newborns.

If you use Prednisolon during pregnancy or begins to get pregnant while taking the drug, the patient must be informed in advance for the danger to the fetus. In general, using corticosteroids in pregnant women requires consideration of benefits that can be achieved compared to the risks that may occur for mothers and children.

Breastfeeding period

Prednisolon secretes breast milk with a concentration of milk in 5-25% of the concentration of the mother serum, about 0.14% of the mother's daily dose. Be careful when using Prednisolon for nursing mothers. Mothers taking high doses of corticosteroids for a long time can affect the growth and development of breastfed babies and affect endogenous corticosteroid production. Must consider the benefits/risks for both mother and child. If forced to use Prednisolon for breastfeeding people, the lowest dose must be used enough to achieve clinical effect.

Interactive drug

Interaction with alcohol/nutrition/Herbal:

alcohol: Avoid alcohol (because it may increase the irritation of the stomach lining).

Food: Prednisolon affects calcium absorption. Restricting caffeine. Avoid exposure to cats, Echinacea (due to immunity stimulation).

Storage

Leave a cool place, avoid light, temperatures below 30⁰C.

To be out of reach of children, read the instructions carefully before use.

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