Prednisolone 5mg TV.Pharm anti -inflammatory, anti -allergic and immunosuppressant (10 blisters x 20 tablets)

Dosage form Box of 10 blisters x 20 tablets
Specifications Prednisolone

Ingredient

Composition information	Content
Prednisolone	5mg

Uses

indicated

Prednisolone 5mg is indicated in the following cases:

Indicated when the anti -inflammatory, anti -allergic and immunosuppressive effects are needed. joints: Support short -term treatment in acute, severe stages of rheumatoid arthritis, psoriasis arthritis.

Respiratory disease: granuloma (especially with hypercalcemia), pulmonary tuberculosis or spreading when used simultaneously with appropriate chemotherapy. glucocorticoid.

Prednisolon is a glucocorticoid that has a clear anti -inflammatory, anti -allergy and immunosuppressant effect.

Prednisolon only has weak mineralocorticoid effects, so if you take the drug in a short time, there is very little risk of keeping Na+ and edema.

Anti -inflammatory effects of Prednisolon compared to other glucocorticoids: 5 mg Prednisolon is valid equal to 4 mg of methylprednisolon and equal to 20 mg of hydrocortisone.

Dynamic pharmacokinetics

Oral bioavailability of Prednisolon approximately 82%. Plasma peak concentration is reached 1-2 hours after drinking. Prednisolon binds to protein about 90-95 %, the clearance of Prednisolon is 8.7 + 1.6 ml/min/kg.

The distribution of the drug is 1.5 ± 0.2 liters/kg.

Prednisolon is metabolized in the liver and metabolites are ester sulfate and glucuronids are excreted into the urine.

Prednisolon waste time is approximately 1.7 - 2.7 hours.

Before taking Prednisolone 5mg TV.Pharm anti -inflammatory, anti -allergic and immunosuppressant (10 blisters x 20 tablets)

How to use

prednisolone 5mg round tablets used orally.

Dosage

as directed by the doctor or the following dose.

Adults:

Dosage 20 - 40 mg/day (granting status of up to 80 mg/day) gradually reduces the dose to maintain when symptoms have decreased.

Although the dosage is suitable compared to the actual doses used, the usual dose will be determined by clinical response as in adults. Minimize the inhibition of the hypothalamus-Yen-Theme and the developmental retardation in children.

What to do when overdose?

When an overdose occurs, it is necessary to consider or stop Prednisolone.

What to do when forgetting the dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

The most common effects occur most when using high -dose and long -doses of prednisolone.

Common

Insomnia, nervousness is easily agitated.

Increased appetite, indigestion.

Dizziness, convulsions, mental disorders, brain tumors, headaches, mood changes, delirium, hallucinations, refreshments.

edema, hypertension.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Prednisolone 5mg drug contraindicated in the following cases:

Hypersensitivity to any component of the drug.

Caution when using

Use carefully in people with osteoporosis, newly connected people (intestines, blood vessels), mental disorders, stomach ulcers, duodenum ulcers, diabetes, hypertension, heart failure and growing children. Okay.

The effect of the drug on the ability to drive and operate machinery

The drug can cause dizziness, so it is cautious for train drivers, vehicles and machinery.

Pregnant and lactating women

pregnancy:

Using corticosteroids in pregnant women requires consideration of benefits that can be achieved compared to the risks that may occur with mother and child.

Breastfeeding period:

Prednisolone secretes breast milk with less than 1% of the dose and may not be clinically significant.

Drug interaction

Prednisolone is a Cytochrom P450 enzyme induction and is the substrate of the P450 CYP 3A enzyme, so this drug affects the metabolism of ciclosporin, erythromycin, phenobarbital, phenytoin, carbamazepin, ketoconazole, rifampicol, rifampicol, rifampicol, rifampicol, rifampicol, rifampicol, rifampicol, rifampicol Phenytoin, phenobarbital, rifampicin and diuretics decreased potassium can reduce the effect of prednisolone.

Prednisolon can cause hyperglycemia, so higher insulin dose is needed.

Avoid simultaneous use of prednisolon with nonsteroidal anti -inflammatory drugs as it can cause stomach ulcers.

Storage

Store in a dry place, the temperature does not exceed 30ºC, avoiding light.

Other drugs

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