Prednison 5mg Domesco anti -inflammatory and immunosuppressant (100 tablets)

Dosage form Bottle of 100 tablets
Specifications Prednisone

Ingredient

Composition information	Content
Prednisone	5mg

Uses

Indications

Prednison 5mg pink pink bottle of 100 capsules are indicated in cases where anti -inflammatory and immunosuppressive effects:

rheumatoid arthritis, body lupus, some forms of vascular inflammation, temporal artery and inflammation around the artery, sarcoid disease, bronchial asthma, colitis ulcer, hemolytic anemia, granulocytopenia and severe allergens including anaphylaxis. last. Glucocorticoid has anti -inflammatory, anti -allergic and immunosuppressive effects.

Glucocorticoid inhibits inflammation, reduces the number of lymphocytes, eosin blood cells, mononuclear leukocytes in peripheral blood and reducing their movement into inflamed areas.

Glucocorticoid also inhibits the function of lymphocytes and macrophages of tissue.

The effect of glucocorticoids is particularly pronounced on the macrophages, limiting their macrophages, limiting the ability to kill microorganisms and limiting the production of Interferon - Gama, Interleukin - 1, fever, collagen and elastase, the element that causes joint destruction and plasminogen activity. Glucocorticoid acts on lymphocytes that reduce the production of Interleukin - 2.

Glucocorticoid also affects inflammatory response by reducing prostaglandin synthesis due to phospholipase inhibition A2. Glucocorticoid also increases lipocortin levels, inhibits phospholipase A2. Finally, glucocorticoid reduces the appearance of cyclooxygenase in inflammatory cells, thus reducing the enzyme to produce prostaglandin.

Glucocorticoid reduces capillary permeability due to the inhibition of the activity of kinine and bacterial endotoxins due to reducing the amount of alkaline hydrophilia. Glucocorticoid with low doses has anti -inflammatory, high doses that have immunosuppressive effects. Large doses of drugs can reduce the production of antibodies, and the average dose does not have this effect.

In some cases, glucocorticoids kill lymphocytes - T. T. Normal T lymphocytes in peripheral blood have high resistance to glucocorticoid cell death. However, unusual lymphocytes, including some cancer cells, may be much more sensitive. High doses of glucocorticoids can cause cell death according to the program (apoptosis). These anti -lymphocytes are used in chemotherapy for acute lymphocytes and lymphoma. Mild acute asthma attacks are usually treated with a short spell glucocorticoid oral. All adrenal function inhibitors are usually out of 1 to 2 weeks. In the treatment of chronic bronchial asthma, there is always a long -term glucocorticoid use with different doses over time depending on the various severe serious disease.

Glucocorticoid is used in the treatment of many low diseases and in autoimmune diseases such as systemic lupus erythematosus and many inflammatory diseases such as inflammation around the button artery, Wegener, giant cell artery.

For these severe disorders, the glucocorticoid dose starts to be sufficient (higher than the dosage that has anti -inflammatory effects) to reduce the disease quickly and to minimize tissue lesions, followed by a period of consolidation with a single daily dose that is gradually reduced to the minimum dosage.

Glucocorticoid has a good effect in some people with chronic ulcerative and Crohn disease, short -term allergic diseases such as hay sauce, serum, urticaria, contact dermatitis, drug reaction, bee and neuromuscular - vessel, autoimmune diseases such as chronic hepatitis.

Use glucocorticoid alone or in combination with other immunosuppressive drugs to prevent transplantation and to treat other autoimmune diseases.

To prevent acute transplantation, requires high doses of glucocorticoids for several days and to prevent the graft against the level of glucocorticoid doses slightly lower. That may occur after bone marrow transplantation. Using long -term glucocorticoids to prevent grafting often causes many unwanted effects, including increased risk of infection, gastrointestinal ulcer, osteoporosis glucose.

In the case of meningitis, glucocorticoids need to be used before using antibiotics to minimize the harmful effects of inflammation due to bactericidal response in the central nervous system. Glucocorticoid is the leading therapy for nephrotic syndrome. In glomerulonephritis can use glucocorticoid therapy Japanese, for 8 to 10 weeks, then gradually reduce the dose for 1 to 2 months.

In autoimmune hemolytic anemia, if the main cause is not cured or if an emergency intervention is needed, Glucocorticoid is an effective treatment.

Sarcoid disease is treated with glucocorticoid. Due to the increased risk of secondary tuberculosis, patients who have tuberculosis must be treated for tuberculosis prevention.

Dynamic pharmacokinetics

Quickly absorbing through oral, bioavailability is approximately 82%, plasma peak concentration reaches 1-3 hours after taking the drug. Prednison binds to protein about 90 - 95%, clearance is 8.7 ± 1.6 ml/min/kg. The distribution of drugs of 1.5 ± 0.2 liters/kg.

Semi -selling time changes on average 3.4 - 3.8 hours. Prednison metabolizes the liver into Prednisolon and excreted through urine (80% combination and 20% unchanged form).

Before taking Prednison 5mg Domesco anti -inflammatory and immunosuppressant (100 tablets)

How to use

Prednison 5mg pink pink pink tablets for oral.

Dosage

depending on the patient's condition and response, which is used in different doses.

Dosage with chronic disorders (endocrine disorders, skin diseases, hematology and a few inflammatory diseases) use the starting dose: 5 - 10 mg/day and gradually increase to the lowest dosage.

Dosage in cases of adrenal weakness: 2.5 - 10 mg/day.

Dosage in allergies, rheumatism: 20 - 30 mg/day.

Severe diseases: Glue -generating diseases, starting 30 mg/day.

When a long -term treatment is needed, it is advisable to consider the Japanese -way drug regimen, only in the morning in the morning in the natural span of Glucocorticoid 24 hours, so it will be less ADR because there is a recovery time between 2 doses. After long -term treatment, the drug must be gradually stopped.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Overdose:

Overdose symptoms include manifestation of cushing syndrome, severe infections, stomach damage, cataracts, muscle weakness and osteoporosis, salt and water causing edema, alkaline infection, reduced potassium and hypertension, increased insulin, grow slowly in children, causing acne, skin patterns, obesity in the body, fat in the neck and shoulders, face, temperament, and mental implications. Glucocorticoid for a long time.

How to handle:

In these cases, it is necessary to consider to make the right decision to suspend or stop using Glucocorticoid.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Prednison 5mg bottle of 100 tablets, you may experience unwanted effects (ADR).

The most common unwanted effects occur when using high -dose and long -doses of Prednison.

Common

Insomnia, nervousness is prone to excitement, increased appetite, indigestion, hair, diabetes, joint pain, cataract, glaucom, nosebleeds.

Dizziness, convulsions, mental disorders, brain tumors, headaches, mood changes, delirium, hallucinations, refreshments. Acne, skin atrophy, inhibit skin reactions, increase sweating, skin bleeding (hemorrhage spots and hemorrhage), skin hyperpigmentation. Abdominal, esophageal ulcer, pancreatitis. Muscle weakness, calcium, osteoporosis, fracture, sterile necrosis of the femur.

Other

Hypersensitivity reaction, sterile abscess.

Instructions on how to handle ADR

When experiencing the side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Prednison 5mg bottle of 100 tablets contraindicated in the following cases:

Hypersensitivity to one of the ingredients of the drug (excipients: lactose, starch, Avicel, Povidon, Sodium Croscearse, Sodium Lauryl Sulfate, Magnesi Stearat, Colloidal Silicon Dioxid, Hydroxypropylmethyl cellulose 15 CP, hydroxypropylmethylethylethylethylethylylose Glycol 6000, Talc, Titan dioxyd, color erythrosin lake.).

Severe infections, except for bacterial shock and meningitis.

Virus, fungal or tuberculosis skin infections.

Using a live virus vaccine.

Caution when using

Patients with osteoporosis, newly connected people (intestines, blood vessels), mental disorders, stomach ulcers, duodenum ulcers, diabetes, hypertension, heart failure and growing children.

Due to the risk of unwanted effects, it is necessary to use all body glucocorticoids for the elderly with the lowest doses and in the shortest possible time.

Acute adrenal insufficiency may occur when the drug is stopped suddenly after a long time of treatment or when stressed.

When using high doses, it can affect the effect of vaccinations.

Be cautious when used for pregnant and lactating women.

The ability to drive and operate machines

drugs do not affect the driver and operate machinery.

Pregnancy

using long -term systemic glucocorticoids for mothers can lead to newborn weight loss. Using high -dose glucocorticoids in the mother's body can cause a small risk of adrenal hygiene in newborns. In general, using glucocorticoids in pregnant women requires consideration of benefits that can be achieved compared to the risks that may occur with mother and child.

Need to use glucocorticoids for pregnant women with asthma because asthma is dangerous to cause an oxygen deficiency for the fetus. Using glucocorticoid before premature birth also promotes maturity of the child's lungs, preventing respiratory decline syndrome.

breastfeeding period

Prednison secreted into breast milk with less than 1% of the dose and may not be clinically significant. Should be careful when using Prednison in breastfeeding women.

Drug interaction

should not be coordinated with SultoPrid and Vincamin.

Note when coordinating: Twisted peaks such as Bepridil, Disopyramid, Bretylium, Solatol and Amiodaron; oral anticoagulants; Digitalin derivatives; heparin; Metformin; hypoglycemia sulfamids; Isoniazid; salts, oxydes and hydroxyds of Mg, AI and Ca; medications for hypertension; Interferon alpha and Vaccin lives in activity.

Prednison is an induction substance of Cytochrom P450 and is the substrate of the P450 CYP 3A enzyme, so this drug affects the metabolism of cyclosporin, erythromycin, phenobarbital, phenytoin, carbamazepine, ketoconazole, rifampicin.

Phenytoin, Phenobarbital, Rifampicin and diuretics decreased potassium can reduce Prednison's effectiveness.

Prednison can cause hyperlem of blood glucose, so it is necessary to use higher insulin doses.

Avoid simultaneous use of Prednison with nonsteroidal anti -inflammatory drugs because it can cause stomach ulcers.

Storage

Where dry, under 30 ° C, avoid direct light.

Stay out of reach of children.

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