Prednison 5mg Uphace medicine for rheumatism (500 tablets)

Dosage form Bottle 500 tablets
Specifications Prednisone

Ingredient

Composition information	Content
Prednisone	5mg

Uses

Indications

Prednison 5mg Uphace drugs are indicated in the following cases:

rheumatoid arthritis: rheumatoid arthritis, stiff spine, gout arthritis, acute and semi -acute arthritis, tendonitis.

Glue -generating diseases: red lupus, low heart, muscle inflammation.

Skin disease: Pemphigus, Herpes water glossy dermatitis, Stevens syndrome - Johnson.

Allergic: Seasonal or year -round allergic rhinitis, bronchial asthma, contact dermatitis.

Pharmacokic

Prednison is a synthetic glucocorticoid. Glucocorticoid has anti -inflammatory, anti -allergic and immunosuppressive effects. Glucocorticoid inhibits inflammatory phenomenon, reduces the number of lymphocytes, eosin blood cells, single -blood cells in the peripheral blood and reduces their movement into the inflamed area.

Glucocorticoid also inhibits the function of lymphocytes and tissue macrophages. Tác dụng của glucocorticoid đặc biệt rõ rệt lên các đại thực bào, làm hạn chế khả năng thực bào của chúng, hạn chế khả năng diệt vi sinh vật và hạn chế việc sản sinh interferon - gama, interleukin - 1, chất gây sốt, các men colagenase va elastase, yếu tố gây phá hủy khớp và chất hoạt hóa plasminogen. Glucocorticoid acts on lymphocytes that reduce the production of Interleukin - 2.

Glucocorticoid also affects inflammatory response by reducing prostaglandin synthesis due to phospholipase inhibition A2. Glucocorticoid also increases lipocortin levels, inhibits phospholipase A2. Finally, glucocorticoid reduces the appearance of cyclooxygenase in inflammatory cells, thus reducing the enzyme to produce prostaglandin. Glucocorticoid reduces capillary permeability due to inhibition of the activity of kinine and bacterial inner toxins that reduce the amount of clotal released by alkaline leukocytes. Glucocorticoid with low doses has anti -inflammatory, high doses that have immunosuppressive effects. Large doses of drugs may reduce antibodies, and the average dose does not have this effect. In some cases, glucocorticoid killes lymphocytes t.

Normal T -lymphocytes in peripheral blood are highly resistant to the death effect of glucocorticoid cells. However, unusual lymphocytes, including some cancer cells, may be much more sensitive. High doses of glucocorticoids can cause cell death according to the program (apoptosis). These anti -lymphocytes are used in chemotherapy for acute lymphocytes and lymphoma.

pharmacokinetic pharmacokinetics

absorption and distribution

Quickly absorbed by oral, bioavailability is approximately 82%, plasma peak concentration reaches 1-3 hours after taking the drug. Prednison linked to protein about 90 - 95%, clearance is 8.7 + 1.6 ml/min/kg. The distribution of the drug is 1.5 + 0.2 liters/kg.

Metabolism and elimination

Semi -selling time changes on average 3.4 - 3.8 hours. Prednison metabolizes the liver into Prednisolon and excreted through urine (80% combination and 20% unchanged form).

Before taking Prednison 5mg Uphace medicine for rheumatism (500 tablets)

How to use

Prednison 5mg drug used oral. The drug is taken at meals or once in the morning.

When a long -term treatment is needed, it is advisable to consider the Japanese -way drug regimen, only in the morning in the morning in the natural span of Glucocorticoid 24 hours, so it will be less ADR because there is a recovery time between 2 doses. After long -term treatment, the drug must be gradually stopped.

Dosage

Adults

Chronic pathologies (endocrine disorders, skin diseases, hematology and some infections): The starting dose of 5 - 10 mg/day and gradually increases to the lowest dosage.

Adsicy weakening: 2.5 - 10 mg/day.

Allergy, rheumatism: 20 - 30 mg/day.

Severe diseases: Glue -generating diseases, starting 30 mg/day.

Children 6 years of age and older

as directed by the doctor.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? There is no specific antidote available, mainly supportive treatment and symptomatic treatment.

electrolytes in serum should be monitored. Corticosteroid high doses due to chronic use related to side effects such as neurological disorders (mental disorders, depression and hallucinations), arrhythmia and cushing syndrome.

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Prednison 5mg Uphace, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Nervous system: Insomnia, nervousness is easily agitated.

Digestive system: Increase appetite, indigestion.

Hormonal disorders and metabolism: Hands, diabetes.

musculoskeletal system: joint pain.

Eyes, nose: cataract, glaucoma, nosebleeds.

Uncommon, 1/1000

Nervous system: dizziness, convulsions, mental disorders, fake brain, headache, mood change, delirium, hallucinations, refreshment.

Cardiovascular system: edema, hypertension, congestive heart failure.

Skin tissue system: acne, skin atrophy, inhibit skin reactions, increase sweating, skin bleeding (hemorrhagic spots and hemorrhage), hyperpigmentation.

Hormone disorders and metabolism: Cushing -form syndrome, pituitary -adrenal inhibition, child growth slowly, glucose intolerance, potassium -decreased, alkaline, amenorrhea, sodium and water, hyperlem of blood glucose.

Gastrointestinal system: Gastro -duodenal ulcer, nausea, vomiting, bloating, esophageal ulcer, pancreatitis.

Muscle system: muscle weakness, calcium reduction, osteoporosis, fracture, sterile thigh bone necrosis.

Other: Hypersensitivity reaction, sterile apxe.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Prednison 5mg Uphace drug contraindicated in the following cases:

Hypersensitivity to one of the ingredients of the drug.

Severe bacterial infections, except for bacterial shock and meningitis.

Skin infections due to viral, fungi or tuberculosis.

Using a live virus vaccine.

Caution when using

Patients with osteoporosis, newly connected people (intestines, blood vessels), mental disorders, stomach ulcers, duodenum ulcers, diabetes, hypertension, heart failure and growing children.

Due to the risk of unwanted effects, it is necessary to use all body glucocorticoids for the elderly with the lowest doses and in the shortest possible time.

Acute adrenal insufficiency may occur when the drug is stopped suddenly after a long time of treatment or when stressed.

When using high doses, it can affect the effect of vaccinations.

Be cautious when used for pregnant and lactating women.

The ability to drive and operate machinery

The drug is at risk of irritation, sleep disorders. Be careful when used for drivers and operating machinery.

Pregnancy

Use a long -term systemic glucocorticoid for mothers can lead to newborn weight loss. Using high -dose glucocorticoids in the mother's body can cause a small risk of adrenal hygiene in newborns. In general, using glucocorticoids in pregnant women requires consideration of benefits that can be achieved compared to the risks that may occur with mother and child.

Need to use glucocorticoids for pregnant women with asthma because asthma is dangerous to cause an oxygen deficiency for the fetus. Using glucocorticoid before premature birth also promotes maturity of the child's lungs, preventing respiratory decline syndrome.

Breastfeeding period

Prednison secreted into breast milk with less than 1% of the dose and may not be clinically significant. Be careful when using Prednison for nursing women.

Drug interaction

should not be coordinated with sulpiride and vincamin.

Note when coordinating: Twisted peaks such as Bepridil, Disopyramid, Bretylium, Solatol and Amiodaron; Oral anticoagulants: Digitalin derivatives; heparin; Metformin; hypoglycemia sulfamids; Isoniazid; salts, oxydes and hydroxyds of Mg, Al and Ca; medications for hypertension; Interferon alpha and Vaccin lives in activity.

Prednison is an induction substance of Cytochrom P450 enzyme and is the substrate of the P450 CYP 3A enzyme, so this drug affects the metabolism of ciclosporin, erythromycin, phenobarbital, phenytoin, carbamazepin, ketoconazole, rifampicin.

Phenytoin, Phenobarbital, Rifampicin and diuretics decreased potassium can reduce Prednison's effectiveness.

Prednison can cause hyperlem of blood glucose, so it is necessary to take a higher insulin dosage. Avoid simultaneous use of Prednison with nonsteroidal anti -inflammatory drugs because it can cause stomach ulcers.

Storage

Where dry, less than 30 ° C, avoid direct light.

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