Predsantyl 4mg Hasan drug anti -inflammatory and immunity (10 blisters x 10 tablets)
Dosage form Box of 10 blisters x 10 tablets
Specifications Methylprednisolone
Ingredient
| Composition information | Content |
| Methylprednisolone | 4mg |
Uses
Indications
Predsantyl 4 mg drug is indicated in the following cases:
Skin disease: regular Pemphigus.
Blood disorders: Self -dissolved hemolyticemia, plateletal hemorrhage. TB meningitis. Methylprednisolon is a synthetic glucocorticoid and a methyl derivative of Prednisolon Methylprednisolon is a powerful anti -inflammatory substance with the ability to inhibit immunosuppression. Glucocorticoid works mainly by attaching and activating the internal cell receptors. Glucocorticoid receptors have been associated with the activating areas of DNA and active code factors that lead to genetic inactiveness through the cyton's histon deacetyi. After using corticosteroids, the clinical effects due to gene manifestations appear after a few hours of other impacts that are unrelated to the gene expression that may appear faster. Corticosteroids affect the kidneys, water balance and electrolytes, lipid metabolism, protein and carbohydrates, skeletal muscles, cardiovascular system, immune system, nervous system and corticosteroid endocrine system during stress. absorption Methylprednisolon is quickly absorbed and the top concentration in mineral plasma 1.5 - 2.3 hours after drinking in healthy adults. Distribution Melhy iprednisolon binds to plasma proteins quickly leaving the blood and distributed into the body tissue, especially muscle, liver, kidney, skin, intestines, an integral distribution of about 1.4 l/kg. Drugs through the placenta and small amount of amount into breast milk. Metabolism Methylprednisolon pharmaceuticals mainly metabolized in the liver is also metabolized through the kidneys like the substrates of CYP3A4, which is also the substrate of ABC (ATP Binding Cassette) P - Glycoprotein, Methyiprednisolon affects the distribution of tissue and other drug interactions. Elimination Methylprednisolon is excreted through the semi -excreted time of methylprednisolon than prednisolon. The total clearance of approximately 5 - 6 ml/kg. Pharmacokinetics in a special clinical object: The clearance of methylprednisolon can be reduced in patients with thyroid disabilities, increasing in hyperthyroidism patients. Pharmacy
pharmacokinetic
Before taking Predsantyl 4mg Hasan drug anti -inflammatory and immunity (10 blisters x 10 tablets)
How to use
Use the drug with just enough water, not chewed. The daily dose can be taken only once or divided into small doses.
The starting dose may vary depending on the treatment and should be maintained until the clinical effect is achieved satisfactory. The treatment period is from 3 to 7 days in the case of rheumatism (except for rheumatoid arthritis causing myocarditis), allergic disease affects skin and respiratory tract, eye disease. If after 7 days has not achieved satisfactory clinical effect, it is necessary to re -evaluate to determine the cause of the disease.
Immediately after achieving satisfactory clinical effect, daily dosage should be gradually reduced until the end of treatment in acute diseases (seasonal asthma, flaky dermatitis, acute facial inflammation) or gradually decreased to minimal maintenance dose effectively in chronic diseases (rheumatoid arthritis, systemic lupus erythematosus, bronchial asthma, allergic dermatitis). For chronic diseases, especially rheumatoid arthritis, the treatment should be gradually reduced from the starting dose not exceeding 2 mg every 7-10 days, should treat rheumatoid arthritis at the lowest maintenance dose possible.
In the daily use of drugs, the drug should be used at 8 am every 2 days.
Elderly
It should be noted for unwanted effects that can cause more serious consequences. In the elderly (osteoporosis, diabetes, hypertension, easily infected, thin skin), especially when the use time is prolonged.
Children
Dosage is based on clinical response and doctor's opinion. Minimum doses should be used effectively in the shortest time. If possible, daily dose should be used.
Dosage
rheumatism
Rheumatoid arthritis
The starting dose depends on the level of disease: 12 - 16 mg (serious), 8 - 12 mg/day (serious medium), 4- 8 mg/day (average).
The starting dose in children is 4 - 8 mg/day.
Acute rheumatism
The starting dose of 48 mg/day until the rate of blood sedimentation (ESR) returns to normal for 1 week.
Collagen vascular disease/artery inflammation
System Reds
Starting dose 20 - 100 mg/day.
Systemic dermatitis
Starting dose 48 mg/day.
Giant cell arteritis/low muscle inflammation
Starting dose 64 mg/day.
Skin disease
Pemphigus usually starts the starting dose of 80 - 360 mg/day.
allergies
Bronchial asthma
Children
Adults and teenagers have at least 2 severe asthma/year use of 40 - 60 mg/day, drink 1-2 times/day. The dose of aerosium corticosteroid can be added to the prolonged β2 bronchodilator. A short oral corticosteroid (3-10 days may continue until the patient reaches out the exhalation (PEP) 80% of the patient's largest exhalation and until the symptoms are out of symptoms.
Allergic disease (contact dermatitis)
Initially recommended dose is 24 mg (6 tablets Predsantyl 4 mg) on the first day, then gradually decreases 4 mg/day (1 tablet Predsantyl 4 mg), used until the total number of drugs is 21 tablets Predsantyl 4 mg (in 6 days).
Eyes/eye inflammation
Starting dose 12 - 40 mg/day.
Respiratory disease
pulmonary sarcoid starts 32-48 mg, used daily.
Blood disorders
Starting dose 16 - 100 mg/day.
cancer (leukemia, lymphoma)
Starting dose 16 - 100 mg/day.
Gastrointestinal tract disease
ulcerative colitis
Initial dose 16 - 60 mg/day.
Crohn's disease
The starting dose may be up to 48 mg/day in the acute phase.
anti -transplantation
The starting dose can be up to 3.6 mg/kg/day.
Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.
What to do when overdose?
Symptoms
There are no specific clinical symptoms when overdose acute methylprednisolon. Rarely report on acute and or death poisoning during corticosteroid overdose. Manifesting Cushing syndrome, muscle weakness and osteoporosis, all occur only when using long -term corticosteroids.
How to handle
There is no specific treatment for methylprednisolon overdose, mainly supportive treatment and methylprednisolon symptoms.
When using too high doses for a long time, adrenal gain and adrenal inhibition may occur. In these cases, it is necessary to consider to make the right decision to suspend or stop using corticosteroids.
What to do when forgetting a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.
Side Effects
When using Predsantyl 4mg Hasan, you may experience unwanted effects (ADR).
Common, (1/100 Mental disorders: Prolonged emotional disorders (depressed or excited). Unknown frequency Endocrine, metabolism and nutrition: Pituitary insertion, symptoms of drug condenser, alkaline hypoglycemia, metabolic acidosis, glucose tolerance disorders, appetite, epidural tumors, carbohydrate tolerance, blood phosphate increased, increased calcium in urine. Mental disorders: Halfy, hallucinations, paranoia, schizophrenia, mental behavior, prolonged emotional disorders (inductance, dependent psychology, suicide thoughts), mental disorders, personality changes, change of nature, confusion, anxiety, insomnia, discomfort. Other: menstrual disorders, dizziness, fatigue, discomfort, acute adrenal impairment and hypotension can be fatal when sudden stopping the drug, embolism, hiccup, liver enzyme, leukopenia, kaposi's u. sarcoma, tendon broken, spinal fracture, glaucoma. Instructions on how to handle ADR When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.
Warnings
Before using the drug you need to read the instructions carefully and refer to the information below.
Contraindicated
Predsantyl 4 mg drug is contraindicated in the following cases:
Systemic fungal infection. Systemic infections, except for patients treated with special medications. Being vaccinated or reducing toxicity in patients needs to use the anti -immune treatment. Inhibits immunity to increase sensitivity to infections corticosteroid inhibits inflammatory reactions and immune function, increases the risk of fungal infections, bacterial infections, virus infections, and increases the severity of the disease. Patients should be exposed to chickenpox, measles, herpes zoster and need to see a doctor immediately if exposed. Passive immunity by injecting antibodies within 10 days after exposure in patients who are using generalized corticosteroids or have used corticosteroids within the previous 3 months. Be cautious when using corticosteroids in patients who are diagnosed or suspected of infection with parasites, it is possible to cause superinfection or spreading larvae, sometimes accompanied by severe intestinal inflammation, gram -negative bacteria, which causes death of corticosteroids with people wearing tuberculosis and need to be combined with tuberculosis, preventive treatment for patients with potential tuberculosis. When using high doses, can affect the vaccination effect of the vaccine immune system There have been cases of skin reactions or hypersensitivity reactions when treated with corticosteroids, need to be cautious before using the drug, especially in patients with a history of allergies, Endocrine system Patients using systemic corticosteroids are greater than the physiological dose (about 6 mg of methylprednisolon) that lasts more than 3 weeks, do not stop the drug suddenly due to the risk of inhibiting the operation of the HPA axis (lower - pituitary - adrenal gland). If the disease does not recur and is uncertain about the risk of HPA axis, whether the whole corticosteroid can be reduced rapidly to the physiological dosage, when reaching a dose of 6 mg/day, it is necessary to reduce the dosage slowly so that the HPA shaft is restored, stop treatment after more than 3 weeks if the disease is sure not to recur. Need to stop treating whole corticosteroids, even if the treatment time is less than 3 weeks if the patient has been treated many times with corticosteroids, especially if used for more than 3 weeks, treated with long -term corticosteroids within 1 year, adrenal insufficiency, using methylprednisolon> 32 mg/day, continuously taking dose in the evening. Acute adrenal insufficiency may occur when stopping the drug suddenly after a long time of treatment or when stressed. Symptoms of stopping drugs occur when stopping the drug suddenly such as anorexia, nausea, vomiting coma, headache, stones, joint pain, skin peeling, muscle pain, weight loss, hypotension. Glucocorticoid can cause or worsen the Cushing syndrome, it is necessary to avoid glucocorticoids in patients with Cushing syndrome. It is necessary to be particularly cautious and periodically monitored when using the drug in patients with hypothyroidism. Metabolic and nutrition disorders Prolonged methylprednisolon treatment can increase blood glucose, severe diabetes. Caution in patients with diabetes (or family with a history of diabetes). Mental disorders Serious undesirable effects on the nerves can occur after a few days or weeks of treatment, although most eye symptoms after decreased dose or termination of treatment. Nervous system Need to be particularly cautious in patients with convulsions and muscle weaknesses. Eyes Caution for patients with Glaucom (a family with a history of Glaucom), an eye infection of the Eye Simple virus may cause a corneal risk. heart High doses of prolonged glucocorticoids may cause blood lipid disorders and hypertension. Use medication carefully and really necessary in case of heart failure and a history of myocardial infarction. Caution should be careful in patients with cardiac drugs such as digoxin because corticosteroids cause electrolytes/potassium decreased disorders. blood vessels Be cautious when taking corticosteroids in patients with hypertension, venous thrombosis. digestive Be cautious with patients with stomach ulcers, duodenum, stitches connecting small intestine, abscess or pus bacteria, ulcerative colitis, appendicitis. Collaborate with NSAID drugs to increase the risk of gastrointestinal ulcers. honey Corticosteroid high doses can cause acute pancreatitis, caution in patients with liver or cirrhosis. Most cases of liver disorders can recover when termination of treatment. musculoskeletal Acute muscle disease when using high doses of corticosteroids, often occurs in patients with neuropathy (myopmen), simultaneous use of neurological - muscle blockers (pancuronium). Caution in patients with osteoporosis (especially in postmenopausal women). Kidney and urinary system Be cautious in patients with renal impairment. Trauma, poisoning, complications body corticosteroids are not indicated for treatment on people with a traumatic brain injury. Other Low doses of corticosteroids in the shortest time or this dose reduces unwanted effects. Precautions when combining aspirin and non -steroid anti -inflammatory drugs different from corticosteroids. Children corticosteroid is the cause of developmental retardation in infants and children. Prolonged treatment causes risk of increased intracranial pressure, high doses that can cause pancreatitis. Children may be more sensitive to adrenal inhibition when treated with topical. Predsantyl products contain lactose, patients with rare genetic disorders in tolerance Galactose, Lapp Lactase deficiency or Glucose - Galactose should not be used. The effect of methylprednisolon on driving capabilities or operating machinery has not been systematically evaluated. Using methylprednisolon can cause unwanted effects such as dizziness, dizziness, visual disorders, fatigue ... If occurring with patients, do not drive, operate machinery, work on high or other cases. methylprednisolon may pass through the placenta. Using corticosteroids in pregnant animals can affect the fetus such as cleft palate defects, pregnancy retardation in the uterus, affecting the brain, there is no evidence that there is a birth defect in babies such as cleft palate. Using methylprednisolon for the mother can lead to a mitigation of babies. There has been a report on cataracts in infants whose mothers use long -term corticosteroids during pregnancy, in general, using methylprednisolon in pregnant women needs to be able to achieve the benefits that can be achieved compared to the risks that may occur with the mother and child. Methylprednisolon breastfeeding women are excreted in small amounts in breast milk, but the dose of up to 40 mg/day is not likely to affect babies. Babies with high -dose mothers may be inhibited adrenal glands, which should only be used for breastfeeding women when considering the benefits of treatment greater than the risks that may occur with children. Rifampin, Rifabutin, Phenobarbital, Phenytoin, Timido, Carbamazepin may reduce the effectiveness of methylprednisolon due to the CYP3A4 enzyme sensor. troleandomycin, grapefruit juice, mibefradil, cimetidin, isoniazid, Aprilitant, fosaprepitant, iTraconazole, ketoconazole, diltiazem, ethinyylestradiol norethindron, ciclosporin, clarithromycin, erythromycin CYP3A4 enzyme inhibitor increases methylprednisolon levels. ciclosporin ciclosporin and methylprednisolon inhibit each other increase the concentration of plasma of either or both drugs. Antiviral drugs (inhibitors of HIV protease) indinavir and ritonavir increases methylprednisolon levels in plasma. In addition, corticosteroids may increase the metabolism of HIV protease inhibitors, thus reducing their concentration in plasma. cyclophosphamide, tacrolimus can affect the clearance of prednisolon if shared. Non -steroid anti -inflammatory drugs (NSAID) and high -dose aspirin There is a risk of increased hemorrhage or gastrointestinal ulcer if used simultaneously with NSAID. Methylprednisolon increases high -dose aspirin clearance, reducing blood aspirin levels. Methylprednisolon's discontinuation can lead to increased serum aspirin levels leading to poisoning. anti -cholinergic drugs Used in combination with methylprednisolon can cause acute muscle disease. Neurological blockers - muscle methylprednisolon antagonists antibiotic effect of pancuronium and vecuronium. antiviral drugs methylprednisolon may reduce the effects of anti -cholinesterase drugs in myasthenia gravis. Diabetes treatment methylprednisolon may cause hyperglycemia, so the dose adjustments of diabetic medications are needed. Anticoagulant (oral) corticosteroid enhances the impact of anti -dynamic drugs of Coumarin. Potassium -causing drugs methylprednisolon can lower potassium when combined with potassium -reducing pills, amphotericin b, motorbike owners β2. aminoglutethimid Adrenal inhibition worsens the endocrine disorders when treating methylprednisolon. Precautions when using
The ability to drive and operate machinery
Pregnancy
Breastfeeding period
Drug interaction
Storage
In a dry place, under 30 ° C, avoid light.
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