Prega 100 Heterero Treatment Treatment of peripheral neuropathy (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Pregabalin

Ingredient

Composition information	Content
Pregabalin	100mg

Uses

indications

Prega 100 drugs are indicated in the case:

Treatment of peripheral neuropathy and central nerve pain; Epilepsy and whole anxiety.

Pharmacology

Pregabalin activity is the same substance as gamma aminobutyric acid, specifically (s) - 3 - (aminomethyl) -5 -methyl hexamoic acid.

Mechanism of action: Pregabalin is linked to auxiliary subunit (Alpha 2 -Delta protein) of the calcium ion channel opening and closing by voltage, of the central nervous system, and capable of pushing [3H] - Gabapentin from the link position.

pharmacokinetics

Pregabalin pharmacokinetics in stable state (Steady State) for healthy volunteers, epilepsy patients using anti -epileptic drugs, chronic pain patients are the same.

absorption

Pregabalin is quickly absorbed when drinking when hungry, and maximum concentration in plasma appears after 1 hour when taking a single dose as well as when taking multiple doses. Pregabalin's bioavailability when used by oral is estimated at 90%, and does not depend on the dose. After using multiple doses, it will achieve a stable state within 24 to 48 hours.

Pregabalin absorption speed is reduced when used with food, resulting in a cmax reduced by about 25-30% and TMAX is slowing down about 2.5 hours. However, the use of pregabalin along with non -clinical foods of pregabalin is absorbed.

Distribution

Preparation studies have shown pregabalin to overcome the bloody barrier in mice, rats, monkeys. Pregabalin also overcame the placenta in the rat, and was present in the milk mouse to breastfeed. In humans, the distribution of pregabalin when used by oral is about 0.56 l/kg. Pregabalin is not linked to plasma proteins.

Metabolism

In the human body, the metabolism of pregabalin is negligible. After taking a dose of radioactive Pregabalin, about 98% of the recovered radiation in the urine is in the form of intact pregabalin without metabolic. Pregabalin N - methylation is a major metabolic substance of pregabalin and is present in the urine, accounting for about 0.9% of the drug.

In preclinical studies, pregabalin is racemicized through the conversion of isomer S to the isomer form r.

Elimination

Pregabalin is exposed to blood from the blood, in the form of intact drugs without metabolism. The average selling time of pregabalin is 6.3 hours. Cregabalin clearance from plasma is proportional to the clearine clearance. Therefore, it is necessary to adjust the dose for patients whose renal function decreases or must be hemolysis.

linear/non -linear

Pregabalin pharmacokinetics are linearly in the recommended dose range. The difference in pharmacokinetics between individuals on pregabalin is small (

Before taking Prega 100 Heterero Treatment Treatment of peripheral neuropathy (3 blisters x 10 tablets)

How to use

can use Pregabalin with or without food.

Dosage

Dosage from 150 to 600 mg/day, divided into two or three times.

Pain due to neuralgia

Can start treatment with pregabalin at a dose of 150 mg/day. Depending on the response and tolerance of each patient, the dose may be increased to 300 mg/day after about 3 to 7 days, and if necessary, the maximum dose is 600 mg/day after the next 7 days.

epilepsy

Can start treatment with pregabalin at a dose of 150 mg/day. Depending on the response and tolerance of each patient, the dose can be increased to 300 mg/day after 1 week. It may increase to a maximum dose of 600 mg/day after another week.

All anxiety state

Can start treatment with pregabalin at a dose of 150 mg/day. Depending on the response and tolerance of each patient, the dose can be increased to 300 mg/day after 1 week. After the next 1 week may increase to a dose of 450 mg/day. The maximum dose is 600 mg/day can be achieved after 1 week.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Symptoms

In cases of overdose up to 15 g, there are no harmful reactions that are not expected to be reported in advance. After the drug is marketed, the most common harmful reactions are reported when using the overdose of pregabalin is sleeping, confusion, agitation, always manual operation.

Handling

The treatment of overdose pregabalin includes measures to support the whole body, and if the hemolysis is required.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Prega 100 drug you can experience unwanted effects (ADR).

The immune system disorders: Hypersensitivity, angioior, allergic reactions Disruptive nervous system: dizziness, dizziness, sleeping chicken, losing movement air conditioning, unusual coordination, tremor, hard -out, memory reduction, difficulty focusing on thought, paresthesia. Fire. The following phenomena have been noticed: insomnia, headache, nausea, diarrhea, influenza syndrome, easily agitated, depression, pain, sweating and dizziness, dizziness. Patients need to be informed about this issue at the beginning of treatment.

Regarding the problem of stopping the drug through a long -term treatment with pregabalin, there is no data on the ratio of appearance and the severity of the symptoms of cessation associated with the treatment time and the dose of pregabalin.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Prega 100 drugs are contraindicated in hypersensitivity fields with pregabalin or any excipients in the drug.

Be cautious when used

Depending on the results of the preclice, some diabetes patients gain weight when treated with pregabalin, may have to adjust the dose of hypoglycemic drugs. There have been reports on hypersensitive reactions after the drug is marketed, including circuit cases. Pregabalin must be stopped as soon as the angioedema symptoms like the face, around the mouth, in the upper respiratory tract.

Pregabalin therapy is often accompanied by dizziness, dizziness and sleeping, which can increase the risk of accidents that cause injury (fall) in the population of the elderly. There are also reports after the drug has been marketed on the phenomenon of loss of perception, confusion, mental disorders. Therefore, patients need to be warned to be cautious when taking the drug until they get used to the potential effects of the drug.

In control studies, patients with blurred vision in the group treated with pregabalin have a higher rate in the Placebo group and in most cases, this phenomenon goes away without stopping medication. In clinical research projects, the scientific testing, the ratio of cases of vision loss and the rate of changes in the market in the patient group treated with pregabalin is higher than the rate in the group using Placebo. However, the ratio of changes in the eye -examination test in the Placebo group is higher than this ratio in the drug group.

In the actual treatment after the drug is marketed, there are also reports on side effects on visual, most of which are reports on temporary blurred vision or vision effects. The stop use of pregabalin can resolve or improve these visual symptoms. There are reports on renal failure, and when stopping this side effect, this side effect is stopped.

There is currently no sufficient data on phenomena that occur in the case of stop using anti -epileptic drugs, when using therapy combining these drugs with pregabalin, when seizures have been well controlled, to be able to maintain treatment with just pregabalin.

When using short -term or long -term therapy with pregabalin and stop taking this medication, there may be symptoms of quitting appearing in some patients. The following phenomena have been noticed in these cases: insomnia, headache, nausea, diarrhea, influenza syndrome, easily agitated, depression, pain, sweating, dizziness, dizziness. Patients should be informed about this phenomenon at the beginning of treatment.

Regarding pregabalin use for patients with long -term medication, there is no data on the ratio of cessation syndrome and the severity of this syndrome has sex with the time of using the drug, and the drug used. After the drug was marketed, there were reports on congested heart failure in some patients using Pregabalin.

These reactions are mainly in older patients with cardiovascular disease, and are used pregabalin to treat neurological diseases. Therefore, the use of pregabalin for these patients must be very careful. The stop use of pregabalin can solve these side effects.

Patients with rare genetic problems are galactose intolerance, due to lapp -lactase enzyme deficiency or difficulty absorption of glucose - galactose must not use this drug.

In case of pain in the central nervous system due to spinal cord lesions, the appearance of side effects in general, and side effects in the central nervous system, especially the phenomenon of increasing chicken sleep. This is explained by adding the effects of simultaneous medications (for example, anti -spasms) necessary in this condition. Therefore, doctors prescribed need to be calculated when prescribing pregabalin in the above condition.

The ability to drive and operate machinery

The drug can cause side effects such as blurred vision, dizziness, dizziness, chicken sleep, loss of movement air conditioning, unusual coordination, difficulty focusing on thought and dizziness. Patients need to assess the effects of the drug before performing these activities.

pregnancy

There are no adequate and tightly controlled studies on pregnancy. Only use pregabalin during pregnancy if the potential benefits exceed the risk of pregnancy.

Breastfeeding period

It is unknown whether Pregabalin is excreted through breast milk, but it is present in Cai mouse milk. Because of many breast milk excreted, and because of Pregabalin's biomass potential in animal studies, it is necessary to decide or the mother stops breastfeeding or the mother stops taking this medication, taking into account the importance of using the drug for the mother.

Drug interaction

Pregabalin is mainly eliminated intact, not metabolized in urine. In humans, the drug is metabolized is very small small (

Storage

Store at temperatures below 30 ° C, avoid moisture.

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