Prelone 0.5mg Phil has benign prostatic hypertrophy (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Dutasteride

Ingredient

Composition information	Content
Dutasteride	0.5mg

Uses

Indications

Prelone 0.5mg drugs are indicated in case of prostate hypertrophy treatment.

Pharmacokic

Dutasteride is a 5-Reductase double inhibitor. It inhibits the 5-Reductase Type 1 and Type 2 are enzymes responsible for converting testosterone into 5-dihydrotestosterone (DHT).

DHT is Androgen that plays the main role in prostate hypertrophy.

pharmacokinetic pharmacokinetics

After taking the drug, reaching the peak concentration in serum after 1 to 3 hours, bioavailability is about 60%.

dutasteride is highly connected to plasma proteins.

dutasteride is metabolized by Cytochrome P450: CYP3A4 and CYP3A5 and most are eliminated in the form of metabolism through feces. In a stable state, Dutasteride waste time is about 3 to 5 weeks.

Before taking Prelone 0.5mg Phil has benign prostatic hypertrophy (3 blisters x 10 tablets)

How to use

Prelone 0.5mg drugs are used orally. Prelone 0.5mg can be taken or not with food. When drinking, it is necessary to swallow the whole tablet, do not chew or open the capsule because when exposed to the ingredient inside the drug will irritate the mucous membranes of the pharynx.

Dosage

Adults (including the elderly):

Problem dose of Prelone 0.5mg is a 0.5mg x 1 time/ day.

Although improvement can be seen in an early stage, it is necessary to treat at least 6 months to meet satisfactory treatment. No need to adjust the dose in the elderly.

kidney failure:

No research on kidney failure on dynamic pharmacokinetics of dutasteride. No need to adjust the dutasteride dose in patients with renal failure.

Hepatic failure:

Not studying the effects of liver failure on dynamic pharmacokinetics of dutasteride so should be used carefully in patients with mild and medium liver failure. For patients with severe liver failure, contraindicated use of prelone 0.5mg.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose?

Because there is no specific antidote for Prelone 0.5mg, so when there are suspected symptoms of overdose, symptomatic treatment and appropriate support treatment should be conducted.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using a 0.5mg prelone, you may experience unwanted effects (ADR).

helpless.

Change (decline) of libido.

ejaculation disorders.

Notify the doctor or pharmacist unwanted effect when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Prelone drug 0.5mg contraindicated in the following cases:

Women, children and children are in adolescence.

Caution when using

should be visited by the rectum as well as other assessments to detect prostate cancer for BPH patients before the beginning of Prelone 0.5mg and then periodically check.

dutasteride absorbs through the skin so women, children and minors avoid contact with broken capsules. Should be washed immediately with soap and water if exposed to broken cyst.

dutasteride has not been studied in patients with liver disease. Should be cautious when using dutasteride for patients with mild and medium liver failure.

The ability to drive and operate machinery

Based on Dutasteride pharmacokinetics and pharmacodynamic properties, Dutasteride treatment does not affect the ability to drive and operate machinery.

Pregnancy

dutasteride is contraindicated for women.

Breastfeeding period

dutasteride is contraindicated for women. It is unknown whether dutasteride is excreted through breast milk or not.

Drug interaction

The long -term combination between prelone 0.5mg and enzyme inhibitors CYP3A4 (Ritonavir, Indinavir, Nefazodone, Itraconazole, Ketoconazole) can increase the concentration of Prelone 0.5mg in serum, the increase in Prelone 0.5mg dose does not add to the 5 more than 5 more than 5 more than 5 mm. alphareductuctase. However, the reduction of 0.5mg Prelone dose can cause noticeable side effects.

Note that in the case of enzyme inhibition, the sale time may be longer and may prolong the combination treatment for more than 6 months before reaching a new equilibrium state.

Storage

Store in closed boxes, at room temperature (below 30 ° C).

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