Prezel 75 indift medicine for central neuropathy (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Pregabalin

Ingredient

Composition information	Content
Pregabalin	75mg

Uses

Indications

Prezel 75mg drug is indicated in the following cases:

Treatment of coordination with anti -convulsions to treat local seizures in adults. Learning

Pregabalin is a anti -convulsions and pain relief. Pregabalin has the same structure as the central neurological inhibitor GABA, but is not directly attached to the Gabaa, Gabab, or Benzodiazepin receptors, does not increase the response of GABAA in cultured neurons, nor does it change GABA levels in the mouse brain, does not affect the recovery and gaba.

On cultured neurons, long -term use of pregabalin will increase the density of transport proteins and increase GABA transport speed. Pregabalin is attached to central nerve tissues with high affinity at the position of α2-Δ (a subunit of the calcium channel depending on the voltage). Although Pregabalin's exact mechanism has not been fully known, the attachment to subunit α2-she may be related to pregabalin analgesic and anti-convulsions effects.

In vitro, pregabalin reduces the release of calcium -dependent neurotransmitters such as glutamat, norepinephrin, peptides related to calcitonin regulating genes and P that can be via the function of calcium channel.

pharmacokinetic

absorption

Pregabalin is quickly absorbed in the gastrointestinal tract and the maximum concentration achieved after drinking is 1.5 hours. Oral bioavailability is about 90%. Food reduces the speed, not reducing the level of absorption, but this is not clinically significant. Stable concentration is achieved after 1-2 days.

Distribution - Metabolism

Pregabalin is not attached to plasma proteins and is almost non -metabolized.

Elimination

About 98% are eliminated through the kidneys in a constant form. Half life is 6.3 hours on average. Pregabalin is eliminated by hemolysis.

Before taking Prezel 75 indift medicine for central neuropathy (3 blisters x 10 tablets)

How to use

Pregabalin is used by oral, divided 2-3 times daily, used or not with food.

Dosage

Supplementing local epilepsy treatment

The starting dose is 150mg, daily oral, then gradually increasing the dose after each week depending on the response to 300mg/day and then 600mg/day.

Disseminated anxiety disorders

The starting dose of 150mg per day, can gradually increase the dose after week with a gap of 150mg to the maximum dose of 600mg per day.

Pain due to neuritis, after herpes

Adults

recommended dose: 150 - 300mg/day, divided into 2-3 times.

Starting dose: 150mg/day, can increase to 300mg/day for 1 week, depending on the efficiency and tolerance. If still does not help after 2-4 weeks of treatment with a dose of 300mg/day, can increase to a dose of 600mg/day divided into 2-3 times.

The dose exceeds 300mg/day for people who are still painful and tolerated with a dose of 300 mg/day, because of the potential of many ADR due to high doses.

Diabetes nerve pain

Adults

The starting dose of 150mg/day, divided into 3 times, the dose can increase in the next 1 week of the maximum dose recommended 300mg/day divided into 3 times. Increasing the dose does not increase benefits, but more ADR.

muscle pain due to fibrosis

The starting dose of 150mg/day, increasing after 1 week depending on the response to 300mg/day and 450mg/day if necessary.

For patients with renal failure

Need to adjust the dose by CLCR, specifically as follows:

CLCR 30 - Under 60ml/minute: Start 75mg/day, maximum 300mg/day, divide 2-3 times. Most.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? The highest pregabalin dose reported that 800mg does not see any significant clinical consequences.

Management: There is no specific antidote. If indicated, cause vomiting or gastric lavage, maintain airway if needed. Symptomatic treatment, support. Hematoparology if indicated (eliminating pregabalin is about 50% in 4 hours).

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Prezel 75mg, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Cardiovascular: peripheral edema.

TKTW: Dizziness, sleep, loss of fortune, headache.

Digestive system: weight gain, dry mouth.

Mechanical - Bone: Run muscles.

Eyes: blurred vision.

other: infection.

Uncommon, 1/1000

Cardiovascular: chest pain, edema.

TKTW: Neuritis, abnormal thoughts, fatigue, confusion, refreshment, language disorders, attention disorders, loss of movement, loss/memory loss, pain, dizziness, abnormal feeling, anxiety, depression, loss of orientation, sleep, fever, personality loss, stupor, stunning, stunning. Skin: Facial edema, bruising, itching.

Endocrine and metabolism: stagnant fluid, reducing blood glucose.

stomach - intestines: constipation, appetite, flatulence, vomiting, abdominal pain, gastritis. genital - urinary tract: urine and urinary incontinence, loss of pleasure, sex reduction. Blood: platelets.

muscle - Bone: balancing disorders, abnormal gait, muscle weakness, joint pain, muscle jerky, back pain, muscle spasm, muscle vibration, abnormalities, increased CPK, cramps, muscle pain, muscle weakness.

eyes: visual disorders, vision loss, eyeball vibration, conjunctivitis. ears: hearing loss.

Respiratory: sinusitis, shortness of breath, bronchitis, sore throat - larynx.

Other: influenza syndrome, allergic reactions.

Rare, 1/10000

Agency - Vehicle, acute renal failure, drug dependence (rare), agitation, albuminuria, anaphylactic reaction, anemia, angioedema, language disorders, gastritis, apnea ...

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Prezel 75mg contraindicated drug in the following cases:

Hypersensitivity to drugs or any ingredients in the preparation.

Precautions when used

anti -convulsions, including pregabalin, often increases the risk of suicidal thoughts/behaviors. Therefore, patients need to be closely monitored on depression, the tendency to commit suicide, abnormal behavior changes during the treatment process and need to be instructed to notify the doctor as soon as the above signs appear.

Be cautious when using pregabalin because it can cause peripheral edema. There is no clear combination of peripheral edema with cardiovascular complications (such as hypertension, congestion heart failure) and non -kidney or liver failure. When used in combination, pregabalin with thiazolidinedion (anti -diabetes drugs) are at higher risk of increasing body weight and edema than when using single pregabalin.

Pregabalin causes increased body weight related to the dose and time of drug use; However, weight gain is not related to the body mass index (BMI) before treatment, gender, or age, and not due to edema. Although in short -term research, controlled, weight gain does not combine with important clinical changes in blood pressure, but long -term effects on cardiovascular has not been clarified. In addition, pregabalin does not lose blood glucose.

For patients who have had heart disease before, be cautious when taking the drug because it can increase the risk of heart failure.

Pregabalin can increase CPK and can cause muscle globin - urinary tract (although rare). Patients need to notify the doctor when pain, muscle weakness, increase sensitivity, especially when accompanied by fever or fatigue, discomfort. Must stop the drug when there is a manifestation of muscle disease.

Need to stop slowly and reduce pregabalin dose for at least 1 week before stopping the drug to avoid increased epilepsy as for anti -convulsions in general.

Be careful with patients with a history of drug addiction. Monitor the signs of drug abuse (such as greasy, the trend of increasing the dose or the act of searching for drugs). In control clinical studies, the proportion of patients using pregabalin has a refreshing manifestation of 4% compared to 1% in the control group. In studies on patient populations, this rate is greater, from 1 - 12%. When stopping the drug quickly and suddenly, the symptoms of drug dependence such as insomnia, vomiting, headache, diarrhea.

The ability to drive and operate machinery

The drug that affects the TKTW includes: drowsiness, dizziness, which can reduce both the physical and mental of the patient, so be cautious on driving objects or operate machinery.

Pregnancy

Research on animals (rats, rabbits) pregnant for pregabalin with a dose to create plasma pregabalin concentrations (AUC) 5 or more than 5 times the drug concentration in the maximum dose recommended 600mg/day, see increased rate of malformations in the fetus and the symptoms of poisoning for pregnancy development, including death, development Reproduction in pregnancy.

There is no complete research and good tests in pregnant women.

Only use when the potential for mothers is greater than the potential for pregnancy.

Breastfeeding period

It is unclear whether the drug will be through breast milk or not. Should be cautious when used for breastfeeding women. Rat studies show pregabalin through milk.

Medicinal interaction

Pregabalin increases the concentration/effect of alcohol, anti -diabetic drugs group thiazolidinedion, central neurological inhibitors, methotrimeprazin, selective Serotonin recovery inhibitors.

concentration/effect of pregabalin is increased by droperidol, hydroxyzin, methotrimeprazin.

The concentration and effects of pregabalin are reduced by ketorolac, ketorolac (small nose), ketorolac (systemic line), mefloquin.

Storage

Store at temperatures from 15 - 30oC.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.