Pricefil 500mg Vianex Treatment of respiratory infections (1 blister x 12 tablets)

Dosage form Box of 1 blister x 12 tablets
Specifications Cefprozil

Ingredient

Composition informationContent
Cefprozil500mg

Uses

Indications

Pricefil 500mg drug is indicated for treatment for infected patients causing sensitive bacteria:

  • Upper respiratory infections: sore throat , tonsillitis, sinusitis and acute otitis media.
  • Lower respiratory infections: bronchitis and acute pneumonia.
  • Skin and soft tissue infections.
  • Inhabited urinary tract infections, such as acute acute cystitis . Sensitive and cultured tests should be performed when it is possible to determine the sensitivity of pathogens. Bacteria learned: In vitro, Cefprozil have an anti -bacterial effect of Gram -positive bacteria and broad spectrum. The bactericidal effect of Cefprozil due to inhibiting the synthesis of bacterial cell walls. In vitro, the drug works against most of the following bacteria:

    Gram (+) aerobic bacteria

    Staphylococci: Staphylococcus aureus (only included in methicillin ), Staphylococcus Epidermidis, Staphylococcus Warneris.

    Note: PriceFl does not work with staphylococci resistance methicillin.

    Streptococci: Streptococcus Pyogenes (Streptococci group A) Streptococcus Agalactiae (Streptococci group B), Streptococcus Pneumonia, Streptococci Group C, D, F and G, Streptoccci Viridans group.

    Gram (-) aerobic bacteria

    Moraxella (Branhamella) CatVrhalis, Haemophylus influenzae (including β-lactamase strains), Citrobacter Diversus, Escherichia Coli, Klesella Pneuomoniae, Neisseria Gonorrhoeea (including penicillinases), Production) Mirabilis, Salmonella spp, Shigella spp, Vibrio spp.

    Note: The sensitivity of Citrobacter Diversus and Klebsiella Pneuomoniae should be determined by antibiotics.

    Anaerobic bacteria

    Note: Most of the bacteroides Fragilis group strains are resistant to Pricefil. Clostridium difficile, Clostridium perfringens, fusobacterium spp, peptostreptococcus spp, propionibacterium acnes.

    pharmacokinetics

    After drinking at full or hungry, Pricefil 500mg all absorb well. Birth (absolute) of Pricefil 500mg when taken is 90%. The pharmacokinetics parameters of the drug are not affected when using the drug at full or simultaneously used with antacids. The average peak concentration in plasma after using Cefprozil for patients at hunger is presented in the table below. About 65% of the dose is excreted unchanged in urine.

    Dosage

    Average peak concentration Cefprozil in plasma (µg/ml)

    Excretion through urine for 8 hours

    4 hours

    8 hours

    6,1

    1.7

    0.2

    60%

    500mg

    10.5

    3,2

    0.4

    62%

    1g

    18.3

    8.4

    1.0

    54%

    Distribution

    The cohesion with plasma protein is about 36% and does not depend on the drug concentration of the range of 2µg/ml to 20µg/ml.

    Elimination

    Half of life breaks on average in normal plasma is 1.3 hours. There is no evidence of the accumulation of protinfl in plasma in people with normal kidney function after taking multiple doses of 1g every 8 hours in 10 days. In patients with impaired renal function, half -life decomposition in a prolonged plasma is related to the level of renal dysfunction. In patients completely losing the kidney function, half -life decomposes in the plasma of PriceFil lasting up to 5.9 hours. While hemorrhage, half -life decomposed was shortened to 2.1 hours.

    Average area under the curve (AUC) in elderly patients (> 65 years old) is about 35-60% higher than young people and average AUC in women is about 15-20% higher. In terms of pharmacokinetics of Pricefil, the difference in age and gender does not mean correlation to adjust the dose.

    In patients with liver function impairment, there is no statistical difference in pharmacokinetic parameters compared to normal controlled subjects. After taking a single dose of 7.5mg/kg or 20mg/kg for patients to cut tonsils, the concentration of drugs in tonsils 1 - 4 hours after use is in the range of 0.4 - 4µg/g. This concentration is at least 25 times higher than the concentration of inhibitors (MIC) for Streptococcus Pyogenes.

    • Before taking Pricefil 500mg Vianex Treatment of respiratory infections (1 blister x 12 tablets)

    How to use

    Drugs Pricefil 500mg are used orally.

    Dosage

    Adults and children over 12 years old

    Sore throat - tonsillitis: 500mg every 24 hours.

    Acute sinusitis or recurrent sinusitis: 500mg every 12 hours.

    Acute otitis media: 500mg every 12 hours.

    Lower respiratory infections: 500mg every 12 hours.

    Inhabited urinary tract infections: 500mg every 24 hours.

    Skin and soft tissue infections: 250mg every 12 hours or 500mg every 12 hours or 500mg every 24 hours.

    Children

    Should use the form of drinking powder.

    Children from 6 months to 12 years old have upper respiratory tract infections, such as sore throat, tonsillitis, recommended dose of 20mg/kg, 1 time/day or 7.5mg/kg, 2 times/day.

    The recommended dose in otitis media is 15mg/kg every 12 hours.

    Maximum daily dose for children must not exceed the maximum daily dose for adults.

    In the treatment of bacterial infections caused by beta hemolysis streptococcus, Pricefil should be used for at least 10 days.

    The effectiveness and safety of drugs in children under 6 months of age has not been identified.

    Hepatic failure

    No dose adjustment for patients with liver function failure.

    kidney failure

    No dose adjustment for patients with creatinine clearance> 30ml/min. In patients with creatinine clearance

    Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

    What to do when overdose? In the case of severe overdose, especially in patients with kidney function damage, hemolytic jas can help eliminate cefprozil from the body.

    What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

    Side Effects

    Unwanted reactions occur while using PriceFl 500mg similar to the reactions that are noticeable when using other oral cephalosporins.

    In control clinical trials, PriceFil is often well tolerated. The most unwanted reactions observed in patients treated with Ceprozil in clinical trials are:

  • digestive: diarrhea (2.9%), nausea (3.5%), vomiting (1%) and abdominal pain (1%). Penicillin and cephalosporin, jaundice of the cholestas have a report encountered but rarely. These reactions occur in children more often in adults. Signs and symptoms usually occur a few days after the beginning of treatment and self -loss within a few days after stopping the medication. All these unwanted reactions have recovered. The long prothrombin time is rarely encountered. In the medication monitoring report after circulation, the following undesirable reactions are rarely encountered, although the correlation of the cause with Pricefil 500mg has not been shown: Anaphylaxis, angioedema, bowel inflammation , including fake colitis, diverse pink bowel, fever, prolonged allergic reaction (serum disease), stains-johnson syndrome and platelets.
  • Clinical changes: Transaminase changes, alkaline phosphatase, leukemia, eosin, urea and creatinine, similar to other cephalosporins, encountered in some patients in clinical studies. These disorders are usually mild and transient. Notify the doctor the unwanted effects when using the drug.

    • Instructions on how to handle ADR

    When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

    Warnings

    Before using the drug you need to read the instructions carefully and refer to the information below.

    Contraindicated

    Pricefil 500mg contraindicated in the following cases:

  • Patients who have known allergies to cephalosporin or any ingredients of the drug.

    • Be cautious when using

    Before starting treatment with Pricefil 500mg, it is recommended to check previous allergic reactions with cefprozil , cephalosporin, penicillin and other drugs, because the cross-reaction between β-lactam antibiotics has been proved in about 10% of the historical patient with the history of alive with the history of the history with the history of the history with the history of the history. If an allergic reaction occurs with Pricefil 500mg, the drug should be discontinued.

    Acute or severe hypersensitivity reactions if encountered, need to apply emergency measures. Antibiotic treatment can alter normal bacteria strains in the intestine and overcurrent resistance, such as Clostridium difficile, which is the main cause of fake colitis, which can be life -threatening. It should be noted the appearance of diarrhea in patients with antibiotics and considering fake colitis to apply appropriate treatments.

    Should be cautious when using PriceFl 500mg in patients with a history of chronic gastrointestinal diseases, especially bowelitis. Two reports show that during drug treatment of Cephalosporin, Coombs tested directly for false positive results.

    Should adjust the appropriate dose in patients with renal failure.

    The ability to drive and operate machinery

    It is thought that PriceFL 500mg does not affect the ability to drive and operate the patient's machines. However, like all the drugs, before starting whatever work needs special caution, patients should know the tolerance of the drug.

    Pregnancy

    Animal reproductive studies show that Pricefil 500mg does not harm the fetus. However, studies are incomplete and strictly controlled in pregnant women, so they only use drugs during pregnancy when they are really necessary. There are no studies for the use of PriceFL 500mg during birth, so it should only be treated when really necessary.

    Breastfeeding period

    Total less than 0.3% dose for mothers to produce breast milk. While the harmful effects are not determined for breastfed babies who use Pricefil 500mg, should only be used while breastfeeding when really necessary.

    Drug interaction

    may occur kidney poisoning after simultaneous use of aminoglycosides and cephalosporin.

    Concentrated with probenecid doubled the AUC PriceFil.

    Interactions in subclinical tests: Cephalosporin can give a false positive reaction in the test to determine the glucose in urine with a copper reducing test, but does not occur for enzyme tests. A false negative reaction may occur in the Ferricyanid test that determines the blood glucose. The presence of Pricefil 500mg in blood does not affect the creatinine test in urine or plasma by alkaline picrat.

    Storage

    Store at a temperature not exceeding 30 ° C.

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