Profertil Kalbe medicine for infertility treatment in amenorrhea women (1 blister x 10 tablets) f

Dosage form Box of 1 blister x 10 tablets
Specifications Clomiphene citrate

Ingredient

Composition information	Content
Clomiphene citrate	50mg

Uses

indications

Profitil drug are indicated in the following cases:

Treatment of infertility in menstrual women, Stein-Leventhal syndrome or uterine bleeding function due to ovulation disorders. Citrate has a chemical formula 2- [P- (2-cloro-1,2-diphenylvinyl) phenoxy] triethylamine dihydro citrate.

Clomiphene Citrate is a specific effect on the reproductive organ system in both men and women.

Clomiphene Citrate has both the same effect as estrogen and anti -estrogen.

Clinical trials with Clomiphene Citrate shows that it stimulates ovulation in women and stimulates sperm production in men.

The stimulating effect of the ovulation of Profercil is due to the ability to increase the concentration of FSH and LH in serum by preventing the process of inhibiting these substances by estrogen or androgen.

Not recorded the effect of Profitil on progesterol or Androgenic effects. This is beneficial for the treatment of infertility in women who decrease in ovulation or men's decline in sperm.

Dynamic pharmacokinetics

Drinking, Clomiphene is absorbed in the gastrointestinal tract.

Distribution: There is no data on distribution and cohesion ratio of clomiphene to plasma proteins.

Metabolism: The drug is metabolized through the liver, is slowly excreted from the liver into the biliary tract and enters the liver -round.

Elimination: Clomiphene is excreted mainly in feces, with 51% of oral doses and 37% of intravenous dose is excreted within 5 days. The drug is still eliminated 6 weeks after use. Clomiphene waste sale time is 5–7 days.

Before taking Profertil Kalbe medicine for infertility treatment in amenorrhea women (1 blister x 10 tablets) f

How to use

Adfertil drugs for oral use.

Dosage

The usual dose in the treatment of infertility due to non -ovulation is 1 tablet daily for 5 days, starting from the 5th day of the menstrual cycle or any day if the patient is amenorrhea.

Ovulation usually occurs within 6–10 days after the last dose of Profercil.

If no ovulation occurs after the first treatment, may continue at a dose of 1 tablet daily for 5 days.

If not pregnant after 6 treatments, often less likely to succeed.

For men's decline in sperm, using ProfeTil at a dose of 1 tablet daily for 40–90 days.

The amount of sperm may increase within 4–5 weeks from the beginning of treatment.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

No report on cases of overdose.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Profitil drugs , you may experience unwanted effects (ADR).

Unwanted effects occur when taking the drug at a dose of 100–200 mg daily for 2–3 weeks is the excessive enlargement of the ovaries and the formation of ovarian cysts.

Other unwanted effects such as hot face, digestive disorders , skin rash may occur in some patients sensitive to the drug.

There may be side effects such as blurred vision, headache , insomnia in some cases.

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Profitil drug contraindicated in the following cases:

Patient impaired liver function .

Pregnant women or ovarian cysts.

Pituitary, ovarian dysfunction or other genital organs.

Be cautious when using

need to be very careful when taking the drug for patients in the following cases:

It is necessary to carefully examine the gynecological examination before the patient conducts treatment with Profitil.

The ability to drive and operate machinery

Persons who often drive or operate machinery should use Profercil?

The drug can cause visual disorders, so it is not advisable to drive or operate machinery when taking the drug.

Pregnancy

Women during pregnancy should use Profitil?

Although there is no related data between drugs and birth defects, for safety reasons, only each clomiphene treatment should be started after being sure that the patient is not pregnant.

How to breastfeed

Should women breastfeeding?

Do not use clomiphene for breastfeeding women.

Drug interaction

drug interactions may affect the activity of the drug or cause side effects. Should notify the doctor or pharmacist a list of drugs and functional foods you are using. Do not use or increase or decrease the dose of the drug without the guidance of a doctor.

In special cases, Clomiphene may be used in combination with HMG (Human Menopausal Gonadotrophin; Gonadotrophin in menopausal women) to stimulate the growth follicles and with HCG (Human Chorionic Gonadotrophin; Gonadotrophin of the people's placenta) to stimulate ovulation.

In this case, Clomiphene's side effects may occur significantly (which can be fatal): excessive stimulation of the ovaries causes pain, the function of the ovaries can cause ascites, pleural effusion, blood thrombosis, blood reduction, blood concentration, and the risk of multiple pregnancy in more than 30% of patients.

Storage

Store at temperatures below 30ºC.

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