Progendo 200mg Abbott medicine for uterine hemorrhage due to dysfunction (2 blisters x 15 tablets)

Dosage form Box of 2 blisters x 15 tablets
Specifications Progesterone

Ingredient

Composition information	Content
Progesterone	200mg

Uses

indications

Progeno 200mg drug are indicated in the following cases:

Oral

Prevention of endometrial hyperplasia in non -uterine menopausal women and are using estrogen therapy.

Support the royal phase in tested tube (IVF). doctor's appointment.

Pharmacology

progesterone is a natural progestagen, the main hormone of the body and placenta. It makes the endometrium from the stage of proliferation turn to the period of secretion. Progesterone 200 has natural pharmacological properties of natural progesterone including: pregnancy assist, estrogen resistance, Androgen mild resistance, aldosterone resistance.

Pharmacokinetics

absorption

After drinking, progesterone is absorbed through the gastrointestinal tract and rapid metabolism through the small intestine and liver. With the oral dosage of 100mg of progesterone, the peak of plasma peaks achieved after 2 hours is 12 - 43nmol/l, followed by a rapid reduction in concentrated concentration. After 24 hours, progesterone is no longer detected in the blood. With a daily oral dosage of 100mg, progesterone reaches a plasma concentration in the range of 22 - 35nmol/l, equivalent to the observed concentration in the physical phase of the normal ovulation menstrual cycle.

Bioarization of oral progesterone reaches about 25%, this bioavailability increases with the form of micro -preparation in combination with the transportation of liquid medicine. After placing the vagina, progesterone quickly absorbed through the vaginal mucosa. The maximum concentration in plasma is achieved after 2 - 6 hours and maintained for 24 hours at an average concentration of 9.7ng/ml after the dose of 100mg in the morning and evening. With a dosage higher than 200mg/day, progesterone concentration is equivalent to concentration in the first 3 months of pregnancy.

Metabolism

In plasma, the main metabolites include 20α-hydroxy-D-4α-Preglyolone and 5α-dihydropropesterone. About 66% metabolized through the liver, tissues such as kidneys, brain, urine and skin. Progesterone metabolizes the liver in the form of glucuronide.

Elimination

Mainly through urine, 95% in the form of glucuronide is 3α, 5β-Preceganediol.

Before taking Progendo 200mg Abbott medicine for uterine hemorrhage due to dysfunction (2 blisters x 15 tablets)

How to use

oral and vaginal drugs.

Dosage

Dosage is set according to the hormone levels in each patient's plasma. However, the common treatment is as follows:

Oral:

Prevention of endometrial hyperplasia caused by estrogen in menopausal women:

200mg x 1 time/day, drink at bed during the last 12 days of estrogen treatment every month.

A dose of 300mg progesterone is divided into 2 oral times (used in combination of progendo 200mg and progendo 100mg), 100mg in the morning (Progeno100 mg) after eating two hours and 200mg before going to bed (Progeno 200mg) may be necessary for patients with estrogen -dose of 1.25mg or more.

Progesterone dosage must be adjusted until the uterine response is achieved. In many treatment regimens, the last 5 to 7 days of each month often do not use hormones, this is the time when the bleeding is often seen.

Another treatment that can be available at 1 low dose is to take 100mg of progesterone (use progesterone 100mg) 1 time a day (taking the drug before going to bed) along with estrogen treatment time. This treatment allows the phenomenon of stinging in most patients.

Secondary amenorrhea treatment: 400mg x 1 time/day x 10 days, take medicine in the evening.

Coordination in the treatment of uterine bleeding due to functional disorders: from 200 to 300mg (used in combination of progendo 200mg and progendo 100mg if needed) 1 day divided into 2 drinks.

Vaginal line:

Support the phase of the fertilization in vitro fertilization (IVF): The recommended dose is 400 - 600mg of progesterone in a day, from the first day when GCH is injected until week 12 of pregnancy.

Supporting the period of the royal period in spontaneous cycles or created in reduced fertility, primary or secondary infertility due to the change of ovulation: The recommended dose is 200mg of progesterone per day, from the 17th of the cycle, within 10 days and reuse as soon as possible in the case of menstruation and pregnancy being diagnosed.

threatening miscarriage and consecutive miscarriage due to royal disabilities: The recommended dose is 200 - 400mg of progesterone per day, divided 2 times.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose?

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Progeno 200mg drug , you may experience unwanted effects (ADR).

Abdominal pain, face edema, swelling of the joints or swelling of the legs, blood pressure increased slightly, mild headache, changing personality, anxiety, drowsiness.

Rare, 1/10000

Acne, pain or chest tightness, blush, weight gain, insomnia, nausea.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Please report to the doctor immediately if the following symptoms appear: uterine hemorrhage, bleeding between menstrual cycles, menstruation, menstruation for months. Rarely: depression, skin rash, natural lactation or lots of milk.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Progeno medicine 200mg Contraindications in the following cases:

Oral

Hypersensitivity to progesterone or to the ingredients of the drug. Capsules contain peanut oil (peanuts), so people who are allergic to peanuts (peanuts) do not use drugs.

Used as a pregnancy diagnosis test.

thrombosis, thrombosis, ventricular floods or patients with a history of these diseases.

Did the liver or severe liver disease.

Breast cancer or the reproductive agency has been diagnosed or suspected.

Vaginal hemorrhage has not been diagnosed.

Vaginal line:

Hypersensitivity to progesterone or with the ingredients of the drug.

Vaginal hemorrhage has not been diagnosed.

Be cautious when using

The risks and benefits of drug use must be evaluated and discussed with the doctor before use. Mainly consider the following issues:

People with allergies: notify your doctor if you have an allergic reaction to this drug or any other substance, or food, preservatives, coloring, flavoring or other drugs.

Children: This drug is not prescribed for children.

Elderly: Unwanted effects and problems encountered in the elderly and young people are reported are the same.

Need a general examination before starting treatment.

The history of some diseases can change the effectiveness of this drug.

Should take this medicine away from the meal.

Notice to the doctor in the case of abnormal vaginal bleeding, prolonged or repeated, to eliminate the cause of malignant disease possible.

The ability to drive and operate machinery

Caution for drivers or machinery operating because the drug can cause drowsiness, dizziness.

Pregnancy

only use progendo vaginal, not orally.

Breastfeeding period

progestagens distributed in breast milk in very different quantities, depending on the dose, so do not take the drug while breastfeeding.

Interactive

Interactions can occur with the following drugs: Carbamazepine, Phenobarbital, Phenytoin, Rifabutin and Rifampin.

Storage

A cool dry place, below 30 ° C.

Do not use expired drugs stated on the packaging.

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