Progesterone Injection BP 25mg treatment solution for bleeding due to uterine dysfunction (10 tubes)

Dosage form Box of 10 tubes x 1ml
Specifications Progesterone

Ingredient

Composition information	Content
Progesterone	25mg

Uses

indications

drugs progesterone 25 mg/1 ml are indicated in the following cases:

Treatment uterine dysfunction bleeding .

Make pregnancy when you are pregnant in the case of a history of miscarriage many times due to the omission of the royal period, and in cases of choice such as auxiliary medicine for treatment with infertility results by techniques such as in vitro fertilization (IVF) or transfusion into the fallopian tube (GIFT) for easy fertilized egg transplantation into the uterus.

Pharmacokology

progesterone is a steroid hormone secreted mainly from the royal in the second half of the menstrual cycle. It is the initial sample substance of the progestin group (also known as the progesterone group) consisting of some natural hormones or chemical synthesis with some pharmacological effects of progesterone. Progesterone is formed from steroid precursors in ovaries , testes, adrenal shells and placenta . Hormone creation (LH) stimulates synthesis and excretion progesterone creation.

progesterone helps eggs nest and essential to maintain maternity. The hormone is secreted with high concentrations in the second half of pregnancy. Along with the amount of endogenous estrogen fully secreted in normal women, progesterone will cause endometrium to increase the proliferation to the period of secretion (the period of the royal period). Progesterone reduces sudden secretion at the end of the menstrual cycle is the main cause of the beginning menstruation .

Progesterone also works less and thickens cervical mucus, making sperm difficult to penetrate. Progesterone slightly increases the body temperature in the period of menstruation.

Progesterone stimulates breast follicles and relaxes the uterus.

Pharmacokinetics

absorption

Progesterone is quickly absorbed after being inserted into any sugar.

Distribution

Progesterone binds with serum protein (96 - 99%), mainly with serum albumin and with corticosteroid bond globulin.

Metabolism and elimination

The semi -discharged cycle in plasma is about 5 minutes and a small amount is temporarily stored in body fat. Progesterone does not have a significant effect if taken due to strong metabolism when passing through the liver for the first time. In the liver, progesterone is converted into pregandiol and binds to glucuronic acid and then excreted in the urine in the form of Pregnandiol Glucuronid.

Before taking Progesterone Injection BP 25mg treatment solution for bleeding due to uterine dysfunction (10 tubes)

How to use

Progesterone injections 25 mg/1 ml for intramuscular injection. Should be injected with worms in the butt more than injected into the thighs or muscles, using 1.5 -inch needles (3.8 cm). This area has many fat cells that create a place for progesterone to release slowly.

Dosage

Bleeding due to uterine dysfunction

5 - 10 mg daily for 5 to 10 days to 2 days before menstruation.

Make pregnancy

Two times per week or more (maximum: daily). Injecting 25 - 100 mg from the 15th day or the date of transplanting embryo or gametes and usually lasts up to about 8-16 weeks of pregnancy when progesterone secretion from the placenta is set. The daily dose may be increased to 200 mg depending on the instructions of the physician.

Because the prescription of Progesterone injection 25 mg/1 ml is limited to women of reproductive age, it is not suitable for proposing doses for children and the elderly.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Treatment is monitoring and if necessary, symptomatic treatment and supportive measures.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Progesterone 25 mg/1 ml, you may experience unwanted effects (ADR).

Bleeding due to breakdown, menstrual changes, menstruation , changing cervical erosion and changing fluid secretion, changing in the breast, edema, weight gain, catabolism, jaundice of cholestasis , allergic reactions and skin rash, mental weakness, fever, insomnia , sleepy, nausea, hair loss

Instructions on how to handle ADR

Please inform your doctor immediately if there is a side effect during treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Progesterone drug 25 mg/1 ml contraindicated in the following cases:

Hypersensitivity to progesterone, vaginal bleeding of unknown causes, almost miscarriage or incomplete miscarriage, a history of arterial blockage due to thrombosis, Breast cancer or genital cancer, thrombosis, brain hemorrhage , clear liver failure.

Used as a pregnancy diagnostic test.

Caution when using

must use the Progesterone injectable 25 mg/1 ml carefully for patients in cases may worsen due to fluid retention (for example: hypertension, heart disease, kidney disease, epilepsy ), patients with a history of mental weakness, diabetes Migraine or clear.

If you lose a part or completely vision, suddenly or slowly for unknown reasons, convex or double -sighted, eyeliner, retinal blood vessels, or migraine occurs during treatment, stop the medication and take the appropriate diagnosis and treatments.

The ability to drive and operate machinery

Because the drug can cause drowsiness, after taking the drug should not drive and use machinery.

pregnancy

Progesterone injection 25 mg/1 ml can be used to keep the fetus when there is not enough endogenous progesterone produced from the royalties. No need to use Progesterone 25 mg/1 ml when there is sufficient progesterone secretion from the placenta. The 25 mg/1 ml progesterone injection contains progesterone like a natural hormone, and it does not combine with the conversion of a girl as a fetus like synthetic progestin.

breastfeeding period

detect progesterone in breast milk. Because the effects of injections for breastfed babies have not been determined, the progesterone should not be used 25 mg/1 ml during breastfeeding.

Interactive drug

Progesterone injection 25 mg/1 ml may affect the results of bromOriptin. It can affect the results of liver function tests and or hormonal function in the laboratory. It can also increase cyclosporin levels in plasma.

Storage

Store at 25 ° C. Avoid light. The excess medicine must be left. When preserving the solid part can be separated and must be dissolved by warming before use.

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