Prohepatis 200mg Phil treats gallstones, raw bile cirrhosis (20 blisters x 5 tablets)

Dosage form Box of 20 blisters x 5 tablets
Specifications Ursodesoxycholic Acid

Ingredient

Composition information	Content
Ursodesoxycholic Acid	200mg

Uses

Indications

Prohepatis drug are indicated in the following cases:

Melt cholesterol -rich cholesterol -rich gallstones in patients with normal gallbladder function.

Treatment cirrhosis raw bile. Oral UDCA increases this ratio (related to the dose) and can become the main bile acid (40 - 50%), UDCA reduces the secretion of bile cholesterol, mainly due to reducing cholesterol absorption from the intestine.

Dynamic pharmacy

UDCA was discovered in serum for about 10 - 40 minutes after drinking. UDCA only melted in the upper bowel section but absorbed well in the rosary and ileum. Serum peak concentration is achieved after about 1 to 3 hours.

UDCA cleared the liver for the first time about 60% (mainly in the form of glycine). UDCA quickly excreted on the honey.

Glycine-uudca combined may be hydrolyzed to release UDCA. The part is not absorbed to convert bacteria into lithocholic acid, the main product caused by this transformed bacteria, less absorbed into the bile.

Other metabolites, 7 ketolithocholic acid can be reabsorbed and metabolized in the liver into UDCA and lithocholic acid UDCA and its metabolites are eliminated in the feces.

Before taking Prohepatis 200mg Phil treats gallstones, raw bile cirrhosis (20 blisters x 5 tablets)

How to use

Prohepatis medicine is taken orally.

Dosage

Dissolve gallstones rich in cholesterol without contrast

recommended dose: 8 - 10mg/kg/day (2 or 4 capsules/day for most patients). Should be divided into 2 times after meals, with at least half the dose of drinking after dinner.

The treatment time is needed to dissolve gallstones usually for about 6 - 24 months, depending on the size and composition of the stones. Regular monitoring should be monitored with X -ray and continue for 3-4 months when the gallstones are gone.

After successful treatment of gallstones can recur. The time needed to melt gallstones may increase if the drug is suspended (3-4 weeks) during treatment.

Dosage for older patients and children based on body weight (8 - 10mg/kg/day).

Obese patients may need higher doses (up to 15mg/kg/day)

Treatment of primary biliary cirrhosis

recommended dose 10 - 15mg/kg/day (2 or 6 capsules/day for most patients) to treat primary bile cirrhosis in adults and the elderly. Should be divided into 2 to 4 drinks.

Dosage for children based on body weight.

In patients with biliary cirrhosis primary, some rare cases of clinical symptoms may be worse at the beginning of treatment, such as itching may increase. If this happens, it is advisable to continue with one tablet per day, and then increase gradually (the daily dose increases one more capsules per week until the dose is specified.

Children with fibers from 6 to under 18 years old

20mg/kg/day, divided into 2-3 times, if necessary can increase to 30mg/kg/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? In general, the other symptoms of overdose are not sure because the absorption of UDCA decreases when the dose increases and thus increases the elimination through feces.

No need for specific treatments, so the treatment of diarrhea should be treated by restoring water and electrolytes. However, ion exchange resin can be used to connect bile acids in the intestine. Recommended monitoring of liver function tests.

Add more information for special subjects

Long -term treatment, high doses of UDCA (28 - 30mg/kg/day, glass) in patients with primary bile fibrosis (using non -instruction drugs) leading to a higher rate of adverse effects.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Prohepatis , you may experience unwanted effects (ADR).

Very common, (> 1/10). Common, (1/100≤ to

Rare, (1/10,000 ≤ to 1/1,000). Very rare, (

Gastrointestinal disorders

Common: diarrhea in clinical trials.

Very rare: Calcification of gallstones.

Skin and subcutaneous skin disorders

Very rare: urticaria .

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Prohepatis medicine contraindicated in the following cases:

cholecystitis or acute biliary tract.

Decreased gallbladder contractions.

UDCA is not used to melt the contrast bile stones.

UDCA is not used in patients with progressive stomach or duodenal ulcer, or intestinal or liver disorders that hinder the circulation of bile flow from the liver to the intestine, such as ileum cutting and escape holes, end inflammation, cholestasis in the liver and appendages, severe liver disease, acute and chronic.

Patients with UDCA or unobtrusive drugs.

Precautions when using

should have medical monitoring when taking UDCA.

In the first 3 months of treatment, it is recommended to monitor the parameters of liver AST (SGOT), ALT (SGPT) and GT every 4 weeks, then every 3 months. In addition to helping to determine the response and non -response in patients who are being treated with primary biliary cirrhosis, this monitor also helps early detection of hidden liver failure, especially in patients with primary bile cirrhosis.

When used to dissolve cholesterol gallstones:

To evaluate the treatment and timely detection of gallstones, depending on the size of the gravel, X -rays (taken contrast taken) general gallbladder with a upright posture, lying on your back (ultrasound) 6 - 10 months after the beginning of treatment.

Do not use the drug when you do not see the gallbladder on X-rays, or in the case of calcified gallstones, decreased gallbladder contractions or frequent bile cramps.

Women's patients drink UDCA to melt gallstones should use contraceptive measures without cradle -type cradle because the birth control pills contain cradle elements that can increase gallstones.

When used to treat primary biliary cirrhosis, progress:

Very rare cases of unsuccessful cirrhosis (partial degeneration after treatment) are observed.

In patients with primary cirrhosis, some cases of rare clinical symptoms may be worse at the beginning of treatment, such as itching may increase. If this happens, it should be continued with one tablet per day and then increased.

If diarrhea occurs, dose reduction and in cases of prolonged diarrhea, medication should be discontinued.

Should avoid a diet rich in calories and cholesterol.

The ability to drive and operate machinery

UDCA does not affect or negligible effects on the ability to drive and operate machinery.

Pregnancy

without or very little data on UDCA use in pregnant women. Animal studies have shown reproductive toxicity during pregnancy. UDCA is contraindicated during pregnancy.

Breastfeeding period

According to some cases of breastfeeding women, the concentration of UDCA in milk is very low and may not react to a baby to breastfeed.

Medicinal interaction

should not take UDCA simultaneously with Colestyramine, Colestipol, Activated Chon or Antacids containing Aluminum Hydroxide and/or Smectite (Aluminium Oxide), as these substances are linked to UDCA in the intestine, thus reducing the absorption and effectiveness of the drug's effectiveness. If you need to take the medication, you must take at least 2 hours before or after taking UDCA.

UDCA may affect the absorption of ciclosporin in the intestine. In patients who are treating ciclosporin, carefully monitor ciclosporin levels in the blood, adjust the dose if needed.

In particular, UDCA can reduce the absorption of ciprofloxacin.

In a report on drug interaction, UDCA has the potential to touch the cytochrome P450 enzymes, resulting in reducing the effectiveness of DASSone treatment, as well as detected in the Invitro test. However, it was not observed that induction in an interactive study was designed with budesonide, the cytochrome P4503A.

hormonal estrogenic, oral contraceptives are rich in estrogen and blood cholesterol -lowering drugs such as clofibrate that increases cholesterol secretion in the liver and therefore can create gallstones, affect the effects of UDCA (used to dissolve gallstones).

Storage

In closed containers, cool dry places, avoid light, under 30 ° C.

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