Propain 500 Remedica treats rheumatoid arthritis (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Naproxen

Ingredient

Composition information	Content
Naproxen	500mg

Uses

indications

Propain 500 drugs are indicated in the following cases:

Treatment of rheumatoid arthritis, osteoarthritis, rheumatitis, teenage arthritis, acute gout, acute musculoskeletal disorders, menstruation.

Naproxen shows anti -inflammatory effects even on animals that remove the adrenal glands. This indicates that the effect of the drug is not indirectly through the pituitary - adrenal gland.

Naproxen inhibits prostaglandin synthesis (like other NSAIDs). However, the exact anti -inflammatory mechanism of the drug has not been well known.

Dynamic pharmacokinetics

Naproxen are completely absorbed in the gastrointestinal tract and the peak concentration achieved in plasma after 2 to 4 hours.

In the blood, Naproxen exists primarily in the form of integer and high ratio of plasma proteins. Selling time in plasma is about 12 to 15 hours. The equilibrium concentration is achieved within 3 days after starting the drug in a mode 2 times/day. The level of absorption is not much affected by food and antacids.

Eliminate almost entirely through the urine, mainly in the form of combinations and a raw excretion. Metabolism of drugs in children is similar in adults. Alcoholic chronic liver disease reduces the total level of Naproxen in plasma but increases the concentration of drugs in the form of free.

In the elderly, the concentration of free naproxen increases despite constant total concentrations.

Characteristics

Naproxen, the main active ingredient of propain, belongs to the nonsteroidal anti -inflammatory drug group (abbreviated as NSAIDs), is the derivative of propionic acid.

NSAIDS is used to reduce the symptoms of arthritis such as inflammation, swelling, pain and stiffness. The mechanism of action of NSAIDs is Prostaglandin synthesis.

These drugs do not cure arthritis but can support the treatment process.

Before taking Propain 500 Remedica treats rheumatoid arthritis (10 blisters x 10 tablets)

How to use

oral medication.

Dosage

Adults

rheumatoid arthritis, osteoarthritis and rheumatitis: 500 mg to 1 g per day, divided into 1 or 2 times, each time 12 hours apart. Use the starting dose of 750 or 1 g/day in the acute phase for the following cases:

Patients with pain at night or stiffness in the morning.

Patients switch to propain after using a different anti -joint drug than high doses.

Patients with osteoarthritis with significant pain symptoms.

Acute musculoskeletal disorders and dysmenorrhea: 500 mg for the first time, then use 250 mg at an appropriate dose ranging from 6 hours to 8 hours. The maximum dose for every day after the first treatment is 1250 mg.

Children (over 5 years old)

Adolescence arthritis: 10 mg/kg/day, divided into 2 doses 12 hours apart.

Elderly

Should use the lowest dose effectively.

kidney failure/liver

Patients with renal failure or liver failure should take lower doses. Naproxen is contraindicated in patients with Creatinine clearance

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? Epilepsy appears in a small number of patients but is not determined to be related to Naproxen or not. No life -threatening risk.

When poisoning, a large amount of propain is put into the digestive tract of patients accidentally or intentionally, need to empty the stomach and use common supportive measures. Animal studies show that using an equivalent amount of activated carbon can reduce the absorption of the drug significantly.

Hemorrhage does not reduce plasma naproxen concentration due to high protein bonding ratio. However, the hemorrhage is suitable for patients with renal impairment with Naproxen.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Propain 500, you may experience unwanted effects (ADR).

Like all other drugs, propain can cause some unwanted effects.

On the gastrointestinal tract: Most unwanted effects are the effect on the digestive tract. An ulcer may be encountered, bleeding, gastric puncture, sometimes leading to death, especially in the elderly. Nausea, vomiting, diarrhea, flatulence, constipation, indigestion, abdominal pain, black stools, vomiting blood, mouth ulcers, progressive colitis, Crohn's disease and rarer than gastritis have been recorded. Edema, hypertension, heart failure have been recorded in some patients using NSAIDs. Glomerulonephritis, interstitial nephritis, nephrotic syndrome, ureter, kidney necrosis, renal failure Listening, dizziness, mild peripheral edema, anaphylactic reaction has been recorded. More rare is jaundice, hepatitis, visual disorders, Eosin -preferred pneumonia, vasculitis, hyperkalemia, sterile meningitis and mouth ulcers.

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Propain 500 contraindications in the following cases:

Patients with hypersensitivity to Naproxen or sodium salt of Naproxen.

Patients with a history of hemorrhage or puncture of the gastrointestinal tract related to NSAIDs.

Patients who are or have a history of ulcer, recurrent stomach bleeding (at least 2 ulcers or bleeding) and patients with severe heart failure.

Do not use propain for patients with an increase in allergy symptoms such as asthma, rhinitis, urticaria when taking aspirin and other NSAIDs.

Be cautious when using

avoid combining propain with other NSAIDs, including COX2 selective inhibitors. It is possible to minimize unwanted effects by using the smallest doses to be effective in the shortest time needed to control symptoms. Patients using long -term NSAIDs should be monitored regularly to monitor unwanted effects.

Elderly

The elderly has a higher frequency of adverse reactions to NSAIDs, especially patients with bleeding or gastrointestinal perforation.

Effects on gastrointestinal tract

Bleeding, ulcers, and perforation are symptoms that can lead to deaths that have been recorded for all NSAIDs, whether used at any time, on patients with or no warning signs of stomach and bowel disease. The risk of these symptoms increases when taking high doses, for patients with a history of ulcer, especially for the elderly.

For these patients, it is necessary to start treating at the lowest possible dose. It is advisable to consider and use in combination with protective (Misoprostol or proton -inhibitors) for these patients and patients who have to use in combination with low -dose aspirin or drugs that increase the risk of gastric ulcer. Patients with a history of gastrointestinal diseases, especially the elderly, need to report all abdominal symptoms in the abdomen (especially gastrointestinal bleeding) in the early stages of treatment.

Advise patients to be cautious when they must be used simultaneously with increased risk of ulcer, stomach bleeding such as oral corticoids, anticoagulants (warfarin ...), Serotonin recovery inhibitors, platelet anti -collection drugs (aspirin ...). Stop using propain when patients show signs of ulcer or gastrointestinal bleeding. Precautions when using NSAIDs for patients with a history of digestive disease (colitis, Crohn's disease) because of the risk of increasing unwanted effects.

Bronchospasm can appear in patients with or have a history of bronchial asthma and allergies.

Heart effect

Medicines like propain can slightly increase the risk of cardiovascular disease (myocardial infarction, cerebrovascular disease). This is more likely to happen when using high doses for a long time. Do not overdose and beyond the recommended treatment period. Talk to a doctor or pharmacist if there are heart abnormalities, a history of cerebrovascular disease or high cardiovascular risk (such as high blood pressure, diabetes, high blood cholesterol levels, smoking). Be cautious when using NSAIDs for people with high blood pressure and/or heart failure, stagnation, edema.

Effects on skin

Severe skin reactions, some may cause death, including flaking dermatitis, Stevens-Johnson syndrome, epidermal necrosis is very rarely used by NSAIDs. Patients are at the highest risk of these reactions at the beginning of the treatment stage. Mostly appear in the first month of treatment. Stop using Propain as soon as there are skin rash, mucosal damage or any other hypersensitivity reaction.

Used for patients with renal failure

Be cautious when used for patients with renal failure and should monitor serum creatinine concentration or creatinine clearance. Some patients, especially cases of reducing blood flow to the kidneys, the elderly with impaired renal function, patients who are taking diuretics should be tested for kidney function before and during propain treatment and consider reducing daily dose.

Used for patients with liver failure

It is best to use the lowest dose effectively.

Blood effects

Patients with blood clotting disorders or using drugs that affect blood clotting should be carefully monitored.

Anaphylactic reaction

Hypersensitivity reactions, sometimes lead to death, can appear with hypersensitivity patients.

Visual effect

recorded a few cases of visual disorders (papillitis, optic neuritis after eyeball, gai thi) when using NSAIDs, including Naproxen. Therefore, visual examination should be tested for patients with signs of visual disorders during treatment.

This drug contains lactose, so immediately report to the doctor before taking the drug if you know you are not tolerated with some types of sugar.

The ability to drive and operate machinery

Some patients can sleep chicken, dizziness, dizziness, insomnia, depression when using Naproxen. If there is this symptom, should be cautious when doing jobs that require alertness.

Pregnancy

Like other drugs, Naproxen affects the circulatory system of the human fetus (affecting the closing of the aortic duct). Used for pregnant women, even the lowest level must be carefully considered between benefits and risks, especially in the first 3 months and the last 3 months of pregnancy.

Consult your doctor or pharmacist before using any medicine.

breastfeeding period

Avoid using propain for breastfeeding women. Consult your doctor or pharmacist before using any medicine.

Interactive drug

Some drugs interact with Naproxen and should not be shared.

However, a few of which can be used with special notes. In this case, the doctor may adjust the dose or make some necessary notes. If you use propain, you should notify the doctor or pharmacist the drugs you are using, especially the following drugs:

corticosteroids, anticoagulants (warfarin), sulphonylirros, anti -platelet aggregation drugs, Serotonin recovery inhibitors (SSRIs), Furosemide, Propranolol, Beta channel blockers, Probenecid, Methotrexate, Glycosides Tim, Cyclosporine, MIcledone, Quinolone, Quinolone, Quinolone, Quinolone, Quinolone, Quinolone, Quinolone, Quinolone, Quinolone, Quinolone, Quinolone Inhibition of angiotensin transfer enzymes.

can suspend the use of 48 hours of Naproxen before checking the adrenal gland function as the drug can affect the results.

Storage

Store at less than 30 ° C, avoid light, avoid moisture.

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