Prostarin Abbott drugs to prevent androgen in the skin (1 blister x 21 tablets)

Dosage form Box of 1 blister x 21 tablets
Specifications Cyproterone acetate, ethinyletradiol

Ingredient

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Composition information	Content
Cyproterone acetate	2mg
Ethinylestradiol	0.035mg

Uses

indications

Prostarin drugs are indicated in the following cases:

Prevent some expressions androgen in the skin such as acne, reducing the production of mucus and too much hairs in women.

Cyproteron is a synthetic steroid, highly anti -antibogen activity. Androgenic resistance of cyproteron acetate to compete in inhibition of complex 5 - alpha dihydrotectosteron with cytosolic receptor. The main result of inhibition is to reduce the expression of androgen in the skin (producing excessive mucus and fur in women). Cyproteron when used by drinking effects to prevent ovulation, when used on the skin it is blocked with androgen receptors in the oily gland cell.

Ethinyl estradiol is a synthetic estrogen. With low doses, it has a strong inhibition of follicle growth, reduces the ability to release the ovary and effectively contraception and reduces other side effects such as mid -term bleeding, premenstrual symptoms, headaches when menstruation, menstrual pain.

The combination of cyproteron acetate and ethinyl estradiol helps reduce the amount of androgen in the blood.

Prostarin has the properties of a combined contraceptive pills.

pharmacokinetics

cyproteron acetate

absorption

Cyproteron absorbs quickly and completely through the gastrointestinal tract. The absorption is affected by food. Bioions reach nearly 100%. The peak concentration in plasma is about 7.2 ± 1.4 ng/ml after drinking 4 hours.

Distribution

Cyproteron Acetate is especially affinity for adipose tissue, high associated with 96%plasma proteins.

Metabolism

Cyproteron acetate is metabolized in the liver by CYP3A4 enzyme into a metabolic agent of 15β - hydroxycyproterone acetate, which has an anti -androgen effect but reduces the effect of progestogen.

Elimination

Cyproteron acetate excreted the main liver. 66% through the liver, 33% through urine. The sale time is about 40 hours.

ethinyl estradiol

absorption

Quick absorption and almost entirely through the gastrointestinal tract, the average peak concentration in plasma is about 80 ng/ml, achieved after about 1-3 hours (TMAX). Due to the first system conjugation and metabolic effect, the absolute bioavailability of Ethinyl Estradiol is nearly 60%.

Distribution

Ethinyl estradiol binds almost completely with plasma proteins, especially with albumine and sharply increases SHBG content in plasma. The distribution volume is 5 l/kg.

Metabolism

Ethinyl estradiol has a strong system conjugation. Not mounted on the intestinal wall, it is subjected to phase and conjugate metabolism in the liver (metabolism of phase II). Ethinyl estradiol as well as phase I metabolites, into the bile in the form of glucoronic and sulfate complex and in the intestinal circulation. Plasma clearance is about 5 ml/min/kg.

Elimination

Ethinyl estradiol's exhaust time is about 24 hours. About 40% excreted through urine, 60% in feces in the form of glucoronic and sulfate complex.

Before taking Prostarin Abbott drugs to prevent androgen in the skin (1 blister x 21 tablets)

How to use

take medicine with 1 glass of water, take the same time every day, 21 consecutive days and do not give up any dose.

Dosage

Initial treatment: Start treatment on the first day of the menstrual cycle. In 21 consecutive days (3 weeks) take 1 tablet daily until the blister is over. After taking 21 capsules, stopping for 7 days, during this period of menstruation must occur with almost normal blood.

Continue treatment: after 1 week off, 1 new cycle will start and continue other cycles.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when using overdose? If you suspect overdose, you must go to the medical center immediately.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using prostarin, you may experience unwanted effects (ADR).

If you see the following side effects, you must see a doctor immediately:

The first migraine appears or often headache with abnormal intensity.

If you see the following symptoms while taking this medication, immediately ask the doctor's opinion:

Some possible cases: headache, stomach disorders, nausea, breast tension, average bleeding, weight change, change of sexual ability, depression, skin pigmentation.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Prostarin drugs contraindicated in the following cases:

Patients with a history of jaundice, pregnant women who are pregnant or suspected of being pregnant, vaginal bleeding with unknown cause, history or suffering from myocardial infarction or coronary artery disease, acute liver disease, Dubin syndrome - Johnson, Rotor syndrome, liver tumors.

Processes of veins in the artery or veins, as well as conditions that increase the likelihood of these diseases, sickle cell anemia, breast or endometrial cancer, severe diabetes with vascular complications, mucus disorders, herpes manifestations (herpes) in pregnant women, more severe tumors in pregnancy.

Must see a doctor to make sure you do not have any diseases in contraindications when taking this medication.

Be cautious when using

only use medication as directed by the doctor under close monitoring.

During the use of prostarin, ovulation is inhibited, so prevent the possibility of pregnancy. Simultaneous use of hormones and other contraceptives is not necessary. This drug is not indicated for male patients.

Before starting treatment, the doctor must examine the whole body and gynecological examination. In cases of prolonged treatment, periodic examination must be regularly checked every 6 months.

Doctors need to know the medical history of the patient's family, eliminating blood clotting disorders. In the case of new hairs that occur or become worse, the doctor needs a comprehensive examination to determine the cause.

Women have urination, high blood pressure, ear sclerosis, varicose veins; Scattered sclerosis, epilepsy, porphyrin metabolic disorders, jerky dance, as well as people with intravenous infections or tendency to have diabetes should be monitored with strict medicine.

The ability to drive and operate machinery

There is no report on influence on the ability to drive and operate machinery.

Pregnancy

Do not use drugs for pregnant women because the drug can affect the fetus.

Demonstration period

Do not take medicine for breastfeeding women because the drug can affect the baby.

Interactive drug

Notice to the doctor all the drugs you are taking, including non -prescribing drugs.

Interaction with the following drugs has been described:

barbiturate, Hytans, rifampin, phenylbutazon, ampicillin: Take or repeat can reduce the effectiveness of prostarin.

insulin or diabetes: When taken with, prostarin can cause changes in blood sugar. Therefore, people with diabetes or family history with diabetes should consult a doctor before treatment. The doctor may have to adjust diabetes. Diabetes can affect the dosage and effectiveness of prostarin.
Macrolid group type Troleandomycin: Take the same risk of cholestasis in the liver.

Storage

Keep the drug in a cool dry place, below 30 ° C, avoid light and stay out of reach of children.

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