Pruzena Davipharm treatments for nausea and vomiting during pregnancy (3 blisters x 10 tablets)

Dosage form Film bag tablets
Specifications Box of 3 blisters x 10 tablets
Ingredient Doxylamine, pyridoxin hydrochlorid
Indication Vomiting/nausea

Ingredient

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Composition information	Content
Doxylamine	10mg
Pyridoxin hydrochloride	10mg

Uses

Indications

Pruzena drugs are indicated in the following cases:

Treatment of nausea and vomiting during pregnancy. Due to drowsiness, Doxylamin is used to temporarily reduce insomnia. The drug is also used in combination with cough and anti -congestion drugs to temporarily reduce cough and cold symptoms. In terms of structure, Doxylamin is not related to anti -depression substances.

Doxylamin is an antihistamine that has local anesthesia, muscarinic resistance, cholinergic resistance and sedation.

Doxylamin is in combination with pyridoxin to reduce symptoms of nausea and vomiting in pregnant women.

pharmacokinetics

doxylamin

Doxylamin is well absorbed from the digestive tract. After oral, the drug achieved the peak concentration within 2-3 hours. The drug has a 10 -hour excretion selling time in healthy adults.

The metabolites of the combined, quantitative and qualitative doxicinine doxylamin 0-glucuronid, N-Desmethyl-Doxylamin 0-glucuronid, and N, N-Didesmethyl-Doxylamin 0-glucuronid. These metabolites are excreted into urine and feces.

pyridoxin

easily absorbed through the gastrointestinal tract. Vitamin B6 is accumulated mainly in the liver, less in muscle and brain. The amount of vitamin B6 reserves in the whole body is estimated at about 167 mg.

pyridoxal and pyridoxal phosphate, two main forms of vitamins present in the blood, high associated with protein. Pyridoxin passes the placenta, the plasma concentration of the fetus is 5 times higher than the concentration in the mother's plasma. The concentration of vitamin B6 in milk is about 150 and 240 mcg/ml when the mother uses 2.5 and 5 mg of vitamin B6 daily. When the mother uses

Before taking Pruzena Davipharm treatments for nausea and vomiting during pregnancy (3 blisters x 10 tablets)

How to use

Pruzena drugs are used for oral, the main dose should be taken at bedtime to reduce symptoms in the morning.

Dosage

Adults

Two film tablets (a total of 20 mg doxylamine and 20 mg of pyridoxin) oral at bedtime.

In severe cases or in case of nausea/vomiting throughout the day, an additional dose of 1 tablet may be increased in the morning and/or afternoon.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Pruzena, you may experience unwanted effects (ADR).

Cardiovascular: suspense, tachycardia.

Central nervous system: dizziness, loss of direction, drowsiness, headache, stimulating the nervous system inversely.

Genital urinary: urinary difficulty, urinary retention.

Gastrointestinal tract: Anorexia, dry mucosa.

The usual unwanted effect of Doxylamin Succinat is sleepy. Other unwanted effects include digestive disorders, headaches, blurred vision, tinnitus, excitement or weakness, irritation, nightmares, anorexia, indigestion, dry mouth, heavy chest, hands that feel heavy and weak.

Symptoms of stimulating adults include insomnia, anxiety, tachycardia, tremor, muscle twisting and convulsions.

High doses can cause epilepsy. It may occur allergies and anaphylaxis. Blood organic disorders include granulocytes and hemolytic anemia may occur.

Doxylamin Succinat has anti -cholinergic properties, should be used carefully in diseases such as glaucoma and prostate hypertrophy.

The effect of Atropin and anti -three -round drugs can increase by Doxylamin Succinat.

Doxylamin Succinat may increase the sedative effects of central neurological inhibitors including alcohol, barbiturates, sleeping pills, narcotic painkillers, sedatives.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Pruzena drugs are contraindicated in the following cases:

Hypersensitivity to doxylamin, pyridoxin, other antihistamine drugs derived from ethanolamine or any ingredients of the drug.

Caution when using

can cause drowsiness: Patients should avoid jobs that need vigilance (for example, driving, operating machinery) until knowing the effect of the drug on the body.

The drug may increase the sedative effect of alcohol or central neurological inhibitors. Use carefully in patients with closed angle glaucoma, pyloric obstruction including gastric ulcer), obstruction of the urinary tract (including bladder obstruction and symptomic prostate hyperplasia), hyperthyroidism, intraocular hypertension and cardiovascular disease (including hypertension and tachycardia). Should be cautious when drinking alcohol.

Due to the antiholinergic resistance of antihistamine drugs, it is cautious when using pruzena simultaneously with other drugs. Be cautious in patients with closed angle or open angle, urinary retention, prostate hypertrophy, duodenal pylorus, epilepsy or severe cardiovascular disease. Doxylamin can inhibit positive test results on the skin.

The ability to drive and operate machinery

Patients with dizziness and other central neurological disorders, including visual disorders, should not drive or operate machinery.

Pregnancy

are drugs that have been used by many pregnant women and women of reproductive age without increasing the rate of deformities, without direct or indirect effects on the fetus.

Doxylamin has been approved for use for nausea and vomiting due to pregnancy.

Breastfeeding period

There is no report.

Drug interaction

anti -cholinergic drugs:

Central and peripheral or peripheral antiviral syndrome may occur when used simultaneously with narcotic analgesics, phenothiazine and other mental drugs (especially highly anti -cholinergic resistance), three -round antidepressants, quinidine and several anti -arrhyths, anti -histamine drugs.

Cholinergic drugs:

High -resistant drugs of cholinergic resistance can be opposed to the treatment effects of cholinergic drugs, including Donepezil, Rivastigmin and Tacrin.

Central neurological inhibitors:

The sedative effect can increase when used with central neurological inhibitors, including alcohol, benzodiazepin, barbiturat, narcotic analgesic, and other sedatives. Therefore, sedative effects should be carefully monitored.

alcohol:

Avoid alcohol (may increase the central nervous inhibition).

Isoniazid reacts with pyridoxal to form a hydrazon and thus inhibits the formation of pyridoxal phosphate. Isoniazid also combined with high -dose pyridoxal phosphate pyridoxal affecting the enzyme function of pyridoxal phosphate formation of hydrazon formation increases the excretion of the kidneys of pyridoxin compounds. So isoniazid treatment causes pyridoxin deficiency.

Hydralazin, Cycloserin and penicillamin also affect the use and operation of pyridoxin.

Oral contraceptives reduce the concentration of pyridoxal phosphate in some women.

pyridoxin stimulates the creation of dopamine from levodopa in peripheral tissue, thus reducing dopamine levels in the brain, which loses the treatment of Parkinson's disease.

Storage

In a dry place, avoiding light, the temperature does not exceed 30 ° C.

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