Pulmicort Respules Astra Asters treat bronchial asthma (20 tubes x 2ml)

Dosage form Box of 20 tubes x 2ml
Specifications Budesonide

Ingredient

Thành phần cho 2ml

Composition information	Content
Budesonide	500mcg

Uses

indications

Pulmicort respule drugs are indicated in the following cases:

Treatment of bronchial asthma. Use by inhalation in treatment and prophylaxis of bronchial asthma.

Many experiments show the favorable correlation between local anti -inflammatory activity and systemic glucocorticoid effects with a wide range of dosage safety amplitude.

This is explained by the great metabolism of BudesonID in the early stages of the liver after being absorbed into the bloodstream, about 85-90% and due to the low activity of the metabolites formed.

Dynamic pharmacokinetics

absorption: Maximum concentration in plasma, occurring about 10 to 30 minutes after starting to spray aerosol is about 4 nmol/l after a single dose of 2 mg.

Distribution: About 10% of the dose of pulmicort tapes in the lungs.

Budesonid's distribution voltage in adults is about 300L and in children is 3.1 to 4.8L/kg, Budesonid has high affinity at tissue. The level of cohesion with plasma protein is 85 - 90%.

Metabolism: 90% of pulmicort is inactivated when the first metabolism through the liver creates more polarized metabolites with a body activity of the whole body than 100 times lower than the original compound.

Elimination: Budesonid removal in plasma is 84L/hour in adults and 1.5 - 2L/hour/kg in children.

Before taking Pulmicort Respules Astra Asters treat bronchial asthma (20 tubes x 2ml)

How to use

pulmicort is a backup drug that needs to be used regularly and does not use as a monatlearty to cut acute asthma attacks.

Patients using inhaled bronchodilators are recommended to use bronchodilators before using Pulmicort to enhance the penetration of the drug in the bronchi. Should be separated by a break between 2 inhalation.

Pulmicort Respules should be used with an appropriate air compressor.

Before use, rotate the tube gently so that the ingredients in the tube are evenly distributed.

Keep the single -dose pipe in the top and open the tube by twisting the top (wing).

Put the opening of the pipe into the tank of the gas machine and squeeze slowly. The single -dose drug tube is marked by a line (only in the pulmicort tube of 0.25 mg/ml and 0.5 mg/ml). This line indicates the volume of 1ml when the pipe is located down.

If only 1ml is used, squeeze the internal component until the liquid level reaches the line.

Store to avoid light for opened pipe. Must use opened pipe within 12 hours. It should be noted that if only 1ml, the remaining volume will not guarantee aseptic.

Before using the remaining liquid, swimming (shaking) gently to make the ingredients in the pipe allocated evenly. The deposition can occur when preserving Pulmicort Respules. If after shaking and the drug does not return to the form of an epidemic, you should remove the pipe.

Note:

Gargle with water after each aerosol.

If using a mask, make sure to close the mask is being sprayed with aerosol. Wash your face after each treatment.

Hygiene:

The chamber of aerospm and masking head or mask should be cleaned after each use.

Wash the parts in warm water by using a mild detergent or instructions provided by the manufacturer.

Carefully and dry by connecting the gas chamber to the sprayer or gas path.

Dosage

pulmicort should be used with appropriate aerosol.

The amount of release to patients varies from 40 - 60% of the dose of use depending on the equipment equipment.

Time of aerosol and the amount of drugs released depends on the speed of the air flow, the volume of the chamber and the charging volume.

The appropriate charging volume for most aerosol machine is 2 - 4ml.

Dosage in the treatment of bronchial asthma:

Initial dose or during severe asthma, or during the decrease of oral corticosteroids:

Adults: 1 - 2mg x 2 times/day.

Children: 0.5 - 1mg x 2 times/day.

Maintenant treatment dose:

Depending on the individual and the lowest dose should lose symptoms. The indicated dose is:

Adults: 0.5 - 1mg x 2 times/day.

Children: 0.25 - 0.5mg x 2 times/day.

Pulmicort is a preventive medicine that needs to be used regularly and not used as a monatlearty to cut acute asthma attacks.

Patients do not depend on oral corticosteroids:

Treatment with pulmicort at the indicated dose for the effectiveness of treatment within 10 days. Multi -dose Pulmicort is used.

Special monitoring in patients with oral corticosteroids switches to pulmicort due to the slow normalization of the hypothalamus function - pituitary - adrenal gland has been disordered by the use of oral corticosteroids starting with pulmicort treatment when asthma patients are in a relatively stable condition. The oral road was used for about 2 weeks. Drink.

In children and children with croup, the usual dose of 2mg budesonid inhaled aerosols used once.

The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

The number and ratio of lymphocytes and love decreases.

Overdose can cause adrenal energy and inhibit the hypothalamus - pituitary - adrenal glands.

How to handle: Stop or reduce the dose will cool the symptoms completely, although the hypothalamus - pituitary - adrenal glands can recover slowly.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Pulmicort, you may experience unwanted effects (ADR).

Common, ADR> 1/100

nose - throat: hoarseness; pain, stimulating throat; Stimulating tongue and mouth; dry mouth; Oral Candida.

Respiratory system: cough.

rarely, 1/1000

nose - throat: stimulating larynx; Poor taste.

Digestive system: diarrhea, nausea

Central nervous system: headache; dizzy; feeling thirsty; Tired.

Disorders of metabolism and nutrition: weight gain

Hypersensitivity reactions: instant and late hypersensitivity reactions such as skin reactions (urticaria, erythema, dermatitis); Bronchospasm, angioedema and anaphylactic reaction.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

sensitive to Budesonid or any ingredients of the preparation.

Caution when using

bronchial spasm:

Pulmicort is not indicated in reducing instant bronchospasm, so the inappropriate drug is a asthma treatment treatment or acute asthma drama, which needs positive management measures.

Use oral corticosteroids:

Special monitoring of patients transferred from oral corticosteroids to pulmicort because these patients may still have the risk of reducing adrenal gland function in a significant time.

Systemic effects may occur when using inhaled corticosteroids:

The inhaled steroids are designed to distribute glucocorticoids directly to the lungs to reduce systemic glucocorticoid levels and side effects.

However, inhaled steroids may have adverse effects; The body -body impact of inhaled steroids includes inhibiting HPA axis, reducing bone density, cataracts, glaucoma and slow growth in children.

Patients with infections and tuberculosis:

high doses of glucocorticosteroids can cover signs of current infections and new infections that can occur while taking the drug. It is important to pay special attention to patients with tuberculosis or fungal infection, bacteria or respiratory viruses that progress or hidden.

Liver function:

Losing liver function may affect corticosteroid elimination. This may be clinically related to patients with severe liver function damage.

The distribution system under positive pressure:

Medicines used by respiratory should not be used with positive pressure distribution systems (such as IPPB) in lung diseases such as pneumothorax, cocoons, medium ventricular airflow, unless there is a special drainage system.

The ability to drive and operate machinery

pulmicort aeroser does not affect the ability to drive and operate machinery

During pregnancy and lactation

Classification of risk groups in pregnancy: Group a.

The benefits of asthma control have been rated as superior to adverse effects that may occur to the mother and fetus.

breastfeeding period

budesonid excreted through breast milk. However, due to the relatively low dosage when used in the inhaler, if the drug is present in the milk, it is also low.

If the benefits are higher than the risk that may still be considered for breastfeeding during medication.

Drug interaction

Budesonid metabolizes mainly through CYP3A intermediaries, a subgroup of the cytochrome P450 enzyme system. Therefore, these enamel inhibitors like ketoconazole and iTraconazole may increase the body's budesonid levels.

This is less clinically significant at short -term treatment (1-2 weeks) with CYP3A inhibitors, but it is necessary to consider for long -term treatment.

Storage

Store in a dry place, temperatures below 30 ºC, not frozen. Should throw away the unused respules tube after 3 months after opening.

Always keep the pipe not open in the aluminum package to preserve it to avoid light.

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