Puyol-100 Davipharm medicine for endometriosis, multi-menstruation (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Danazol

Ingredient

Composition information	Content
Danazol	100mg

Uses

Indications

Puyol products contain the main ingredient with pharmacological effects of Danazol, belonging to a group of drugs called Gonadotropin anti -Gonadotropin drugs. Danazol works to reduce some hormones in your body.

Puyol is used for treatment:

Endometriosis (the tissues that normally lining in the uterus and are discharged during your menstrual cycle develops outside the uterus). You may also be prescribed Puyol before or after endometriosis.

Genetic angioedema (a genetic disease that causes swelling of the skin, lungs and the digestive system). This may be related to your menstrual cycle or by cysts (lumps) in the breast. Puyol is used when other treatments are ineffective or cannot be used.

ATC code: g03xa01.

Danazol is a synthetic derivative of ethinyl testosteron.

Danazol inhibits pituitary -ovary axis, should prevent the pituitary gland and hypothalamus gonadotropin. The drug inhibits the sex steroids and attaches to the sex steroid receptors in the cytoplasm of the target tissue, leading to anti -estrogen effects, abusive and androgen effects. The drug has weak metabolic and androgen properties but does not have estrogen and progestogen effects. Androgen activity is related to the dose. In addition, Danazol also reduces many concentrations of IgG, IGM, IGA as well as phospholipids and IgG autoimmune antibodies in patients with endometritis with an autoimmune antibody. Danazol does not inhibit the pituitary gland that releases corticotropine and the adrenal gland releases cortisol.

Some studies show that in women, Danazol inhibits the excretion of FSH and LH between cycles and reduces the concentration of estradiol, progesterone in plasma. However, in some other studies, there is no change in or changing very little concentrations in the plasma of FSH, LH, Estradiol, Progesterone and ProLactin after using Danazol. In men treatment with Danazol shows a decrease in the concentration of FSH, LH, Testosteron and Dihydroepiandrosteron.

In the treatment of endometriosis, danazol inhibits the ovaries to create steroids, thus causing normal endometrial atrophy and peanuts. No ovulation and followed by amenorrhea appear when treated for about 6-8 weeks. Danazol also reduces the rate of abnormal breast development.

Patients with genetic angize treated with Danazol showed that the concentration of esterase inhibitor C1 in the serum increased 4.5 times and the C4 complement increased by 15 times compared to before treatment.

In patients who lack factor VIII (Hemophilia A) and lack of IX (Hemophilia B), Danazol increases the concentration of factor VIII and IX factor. In addition, Danazol also increases the concentration of alpha1-antitrypsin in patients with a shortage of this factor.

Patients with spontaneous platelets treated with Danazole significantly reduced antibodies of platelet resistant IgG, especially in patients who failed with spleen cut and other treatments (such as Colchicin, Alcaloid coconut, corticosteroid).

pharmacokinetics

absorption:

Danazol is well absorbed by oral. In healthy women, when taking Danazol doses 400 mg 2 times/day, for 2 consecutive days, the highest concentration achieved in plasma is about 140 - 460 nanogam/ml, on average about 260 nanogam/ml, 2 hours after the last dose.

Biomedical research shows that the plasma Danazol concentration does not increase linear compared to oral dose. When doubling the dose, plasma Danazol concentration increased by 35 - 40%. Taking medicine with a fatty meal (about 30 g of fat) can increase bioavailability and CMAX is 3-4 times higher than when you are hungry. However, when taking the medicine with the meal, the time to reach CMAX is about 30 minutes slow.

Metabolism:

Danazol is metabolized mainly in the liver. The main metabolites found in urine are 2-hydroxymethylihihweesterone and Ethisteron. These metabolites do not have the activity of gonadotropine resistance. Donazol's activity increases slightly when used simultaneously with active inhibitors of drug metabolic enzymes.

No metabolites have been isolated from Danazol with the same pituitary inhibitor activity as Danazol.

Distribution and elimination:

Information about distribution and elimination of Danazol is still very limited.

Metabolic substances are excreted in urine and feces. Danazol's waste sale time is about 3-6 hours after taking a single dose, but increases to 26 hours if the dose is repeated. Danazol and metabolites can undergo liver -intestinal cycle.

Before taking Puyol-100 Davipharm medicine for endometriosis, multi-menstruation (3 blisters x 10 tablets)

Always use the exact medication as instructed by a doctor or pharmacist. If you are not sure, ask for sure.

How to use

oral medication. Swallowing the whole tablet with a glass of water.

Before the beginning of the treatment, the doctor will check if you are pregnant. If you are in your reproductive age, you should start treatment on the first day of your menstrual cycle to avoid exposure to the fetus. Using reliable contraceptive methods (such as using contraceptive tools in the uterus or barrier method in combination with foam or contraceptive jelly). Do not use contraceptives until the end of treatment. If you have to treat Danazol continuously, your doctor can adjust the dose depending on your response. When your condition is improved, your doctor may recommend taking lower doses.

If you feel the effect of the drug is too weak or too strong, do not arbitrarily change your dose, discuss with your doctor.

Dosage

recommended dose is 200 - 800 mg/day, can be divided up to 4 drinks. Do not drink more than 800 mg (equivalent to 8 tablets 100 mg or 4 tablets 200 mg).

Light endometriosis: Danazol 100 - 200 mg/ time, 2 times/ day continuously for 3-6 months, but you may also need treatment for up to 9 months. If you have severe endometriosis or you still bleed after 2 months of treatment, your doctor may give you a higher dosage. Month. Treatment time is usually 6 months. When the appropriate dose is achieved, the doctor can give you a reduction in the dose for a period of 1-3 months. If there is an exacerbation, the daily dose increases to 200 mg/day. After 3 months, the doctor will check your condition again.What do

do when using overdose? If you overdose or children swallow the drug, contact the nearest doctor and medical center immediately.

Handling: Stop taking medication and contacting the nearest doctor or medical center. Carrying a pills along with the packaging so that the doctor knows what medicine you take and takes measures to handle it promptly.

What to do when you forget 1 dose? Do not drink double the dose.

Side Effects

As other drugs, Puyol can cause unwanted effects, but not everyone encounters.

You have angioedema symptoms such as skin rash, redness, edema (eyelids, face, lips, mouth and tongue), shortness of breath or difficulty swallowing. These are symptoms of hypersensitivity reactions. Chest, jaw or hand, this may be a sign of a heart attack. This can be seen through blood tests or you can see infections such as sore throat, mouth ulcers or fever more often. Non -cancer and cancer and blood -filled cysts in the liver. The epilepsy is available if you have risks.

These are serious unwanted effects. You may need to be closely monitored by a treating doctor.

Other undesirable effects:

weight gain, acne, hair loss (similar to baldness in men). Your menstruation will usually return to normal within 60 - 90 days after treatment, however, sometimes you may also suffer from long -lasting amenorrhea. head). Hypertension, drugs can make the condition worse.

If you have diabetes, your blood sugar level may be affected. Even if you do not have diabetes, you may have blood sugar.

tired, change personality. It can cause tingling or numbness in the hand, sometimes called the toner syndrome.

Unwanted effects:

Light sensitivity. If you have an inherited angioedema, you may have urinating blood.

Change the number of red blood cells or platelets in your blood. You can also see that you have easier bleeding or bruising or unknown reasons. liver).

These changes often do not cause symptoms and return to normal when stopping the drug.

The drug can cause other unwanted effects, immediately notify the doctor if you experience unwanted effects after using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Do not use this medication if you:

Hypersensitivity to Danazol or any ingredients of the drug. Blood (thrombosis).

Do not take the drug if you encounter any case above. Consult your doctor if you are not sure.

Be cautious when using

before using this medication, notify your doctor if you are having the following health problems:

You used to take puyol or similar drugs and encounter unwanted effects such as water accumulation, voice changes, face hair or muscle development.

You have liver or kidney problems. Blood red blood cells become more dense (polycythemia).

You have seizures (epilepsy). Breast.

Surgery or testing:

If you are preparing to have surgery, notify your doctor that you are taking Danazol because this drug may increase the effects of some anesthetic. You take Puyol for more than 6 months, the doctor will give you an ultrasound to check your liver. The doctor may need periodic blood to check your blood and determine your liver and thyroid still functioning normally.

If you encounter the above cases (or if you are not sure), discuss with your doctor before taking the medication.

Use children's drugs: do not recommend using drugs for children.

Take drugs for the elderly: do not recommend using drugs for the elderly.

The effect of the drug on the ability to drive and operate machines

unknown Puyol's effect on the ability to drive and operate your machines. However, some unwanted effects such as dizziness, sense of rotation and vision change can sometimes occur. If encountered, you should not drive or operate machinery.

Use drugs for women during pregnancy and lactation

Pregnant women:

Do not take the drug if you are pregnant, think you are pregnant or intend to get pregnant. Danazol may harm your child. If you are in reproductive age, you must use reliable contraceptive measures during the treatment process, do not use contraception. If you think you may be pregnant, stop taking the medication and immediately notify the doctor.

Women who are breastfeeding:

Do not take the medication if you are breastfeeding. Danazol can enter your baby's body through milk. If you are planning to breastfeed, discuss with your doctor.

Consult your doctor or pharmacist before taking any medication if you are pregnant or nursing.

Medicinal interaction

Notice to your doctor or pharmacist about all drugs you are using or using recently, including prescription or non -prescribing drugs, vitamins or
drugs from pharmaceutical materials.

Notify the doctor or pharmacist if you are taking the following drugs:

Steroids: such as testosteron, estrogen, progesterone (including oral or hormone replacement therapy, also known as HRT). Danazol may increase the risk of muscle weakness or fast muscle cancellation.

Danazol can increase the effects of the following drugs:

Anti -convulsions such as carbamazepin, phenytoin, phenobarbital. Danazol may increase the concentration of these drugs in your blood and may
damage your kidneys.

Danazol can reduce the effects of the following drugs:

Drugs to treat diabetes including insulin.

If you encounter any case above (or you are not sure), discuss with your doctor before taking the medication.

Use puyol with food - Beverage:
Do not take medicine with a fatty meal.
Do not drink alcohol during treatment. Drinking alcohol while drinking Puyol can make you feel uncomfortable and shortness of breath.

Storage

Keep the drug in the original packaging of the manufacturer, cover.

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