Pycalis 20 pymepharco medicine supports erectile dysfunction (1 blister x 1 tablet)

Dosage form 1 tablet box
Specifications Tadalafil

Ingredient

Composition information	Content
Tadalafil	20mg

Uses

Indications

Pycalis medicine 20 mg is indicated in the following cases:

Treatment of erectile dysfunction support. Used when the penis cannot erect when having sex or the erection is not enough to respond in the relationship. Selective inhibitory effect on phosphodiesterase type 5 (PDE - 5) should maintain the effect of nitric oxid nitric is to dilate vascular, increase the amount of irrigated bleeding into the penis to create an erection in sex.

The response time of the drug is 30 - 60 minutes after drinking. The effect of the drug can be up to 36 hours. In order for the drug to have the effect of stimulation or sexual desire.

pharmacokinetic

Tadalafil is quickly absorbed after drinking, the maximum concentration in plasma is reached for about 2 hours. The absorption of drugs is not affected by food and the time of drug use.

Average distribution volume is about 63 l/kg. At the treatment dose, about 94% of the drug is associated with plasma proteins.

The drug is metabolized mainly by CYP3A4 into inactive metabolites. The elimination drugs are largely through feces (61%) and through urine (36%) in the form of inactive metabolites.

Before taking Pycalis 20 pymepharco medicine supports erectile dysfunction (1 blister x 1 tablet)

How to use

Pycalis 20 mg oral before having sex for at least 30 minutes.

Dosage

Adults

Starting dose: 10 mg x 1 time/day.

Can be used by 20 mg x 1 time/day depending on the patient's response.

Tadalafil should not be used more than once within 24 hours.

No need to adjust the dose in the elderly.

Patients with liver failure

Patients with mild to medium liver failure: The maximum dose must not exceed 10 mg x 1 time/day, daily dosage is not evaluated.

Do not use tadalafil for patients with severe liver failure.

Patients with renal failure

Patients with mild renal impairment (Creatinine clearance 51 - 80 ml/min): No dose adjustment.

Patients with medium renal failure (Creatinine clearance 31 - 50 ml/minute): start at a dose of 5 mg not exceeding 1 time/day, maximum dose not exceeding 10 mg x 1 time every 48 hours.

Patients with severe renal impairment (Creatinine clearance

Patients with diabetes

No need to adjust the dose.

Patients have stabilized with Alpha receptor blockers

Should use Tadalafil with the starting dose of 5 mg.

Patients taking strong Cytochrome P450 CYP3A4 inhibitors

Do not use more than 10 mg x 1 time every 72 hours.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

If an overdose occurs, the use of total status support.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using pycalis 20 mg , you may experience unwanted effects (ADR).

Very common, (ADR

headache, blushing, indigestion .

Common, (1/100 Dizziness, insomnia, anxiety, dizziness, nosebleeds , stuffy nose, fever, digestive disorders (diarrhea, vomiting).

skin rash, erythema, hair loss, back pain, limb pain, muscle pain, face edema, water retention, urinary tract infection.

Rare, (ADR visual disorders, prolonged erections, cough, shortness of breath, rhinitis, sinusitis , bronchitis, cellulitis.

If the visual condition has a problem or the erection condition lasts for more than 4 hours, should notify the doctor immediately.

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Pycalis medicine 20 mg Contraindications in the following cases:

Patients use any preparations that contain nitrate.

Be cautious when using

should not use drugs in patients with cardiovascular disease, unstable blood pressure.

The ability to drive and operate machinery

No report.

Pregnancy

Contraindications.

Breastfeeding period

Contraindications.

Drug interaction

Tadalafil is metabolized mainly by CYP3A4, so induction drugs ( ketoconazol ) or inhibition (Rifampicin) CYP3A4 will reduce or increase AUC of Tadalafil.

Concentrated with antacids such as Magnesi Hydroxid/Hydroxid aluminum reduces Tadalafil's absorption rate.

Tadalafil increases the effectiveness of hypotension of nitrate -based preparations. Concomitant use of Tadalafil and nitrate -based preparations that can cause sudden hypotension below safe levels.

Storage

In a dry, cool place (below 30 ° C). Avoid light.

Other drugs

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