Pyclin-150 pymepharco medicine for severe infections (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Clindamycin

Ingredient

Composition information	Content
Clindamycin	150mg

Uses

indications

Pyclin 150 drugs are indicated in the following cases:

Treatment of severe sensitive anaerobic bacteria, anaerobic Gram -positive bacteria: Staphylococcus, Streptococcus, Pneumococcus and sensitive strains Chlamydia Trachomatis, Clindamycin are used in patients with allergies with penicillin or patients using Penicillin inappropriate.

Infectious respiratory infections: tonsillitis, pharyngitis, sinusitis , otitis media and heat pink fever.

Lower respiratory infections: bronchitis, pneumonia, pleural inflammation, lung abscess.

Skin and soft tissue infections: fish eggs, nail boils, cellular inflammation, abscess, moment and wound infections, especially skin and soft tissue infections caused by sensitive bacteria such as circles, inflammation around the nail.

Bone and joint infections: osteoarthritis joints, arthritis infections.

Gynecological infections: endometriosis, cellulitis, felt inflammation in the uterus, uterine abscess - ovaries not due to gonorrhea, wide ligament inflammation.

Infection in the peritoneal: Peritonitis, abscess in the abdomen.

Tooth infection; periodontal abscess, periodontitis.

Infections and endocarditis.

Pharmacology

Clindamycin is an antibiotic that has an impact on inhibiting the protein synthesis of sensitive bacteria by attaching to the bacterial ribosom 50s, preventing peptid connection formation. Clindamycin is an alkaline antibiotic, but at high concentrations of drugs that have bactericidal effects.

antibacterial spectrum:

staphylococcus aureus; Staphylococcus epidermidis (secretion or not penicillinase secretion); Streptococci (except for Streptococcus Faecalis); Pneumococci; Bacteroides spp. including B. Fragilis, B. Melaninogenicus); Fusobacterium spp.; Probionibacterium; Eubacterium and Actinomyces spp; Peptococcus spp.; Peptostreptococcus spp; Microaerophilic streptococci; Clostridia; Clostridium perfringenes.

pharmacokinetics

clindamycin is sustainable with acidic environment so it can be taken orally. About 90% of the dose is well absorbed through the digestive system. In Vivo, Clindamycin Hydrochlorid is quickly decomposed into clindamycin. After taking the drug, it is widely distributed throughout the tissue and fluid in the body, including the bone except for cerebrospinal fluid. More than 90% clindamycin binds to plasma proteins. Metabolic drugs in the liver. Some metabolites have antibacterial activity.

The semi -cancellation time of clindamycin is about 2-3 hours, but may last in infants and people with severe kidney failure.

About 10% of oral medications are excreted in urine in the form of activity or metabolites and about 4% in feces. Clindamycin pharmacokinetics parameters do not change with age if normal liver function.

Clindamycin does not pass the membrane when hemolysis, peritoneal.

Before taking Pyclin-150 pymepharco medicine for severe infections (10 blisters x 10 tablets)

How to use

oral medication.

Dosage

Adults

Dosage may vary from 150 - 300 mg or 300 - 450 mg, every 6 hours depending on infection.

Children

Severe infection: 8 - 16 mg/kg/day divided into 3 or 4 times.

Severe cases: 16 - 20 mg/kg/day divided into 3 or 4 times.

In case of infection due to hemolytic streptococcal b should be treated at least 10 days.

Note; The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when using overdose?

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using pyclin 150 pills , you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive: nausea, vomiting, diarrhea, urticaria.

Rare, 1/10000

Digestive: fake colitis , esophagitis.

immune: Anaphylaxis .

Instructions on how to handle ADR

Notice the unwanted physician when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Pyclin 150 drugs contraindicated in the following cases:

Patients with climbamycin, Lincomycin or other ingredients of the drug.

Be cautious when using

should be cautious when using the drug in patients with a history of gastrointestinal diseases, especially colitis and the elderly.

Because clindamycin does not diffuse much into the cerebrospinal fluid, it is not advisable to use the drug to treat meningitis. Clindamycin accumulates in serious liver failure patients, so the dose adjustments and periodic analysis of liver enzyme must be adjusted for these patients.

The ability to drive and operate machinery

does not affect.

Pregnancy

only use clindamycin when really necessary.

Breastfeeding period

Clindamycin is excreted through breast milk (minerals 0.7 - 3.8 mcg/ml), so should avoid breastfeeding during medication.

Drug interaction

clindamycin increases the neurological inhibition of neurotransmitter factors.

In vitro shows the antagonistic effect between clindamycin and erythromycin, there is a cross reaction between clindamycin and lincomycin. Clindamycin reduces the effect of oral steroidal contraceptives.

Do not simultaneously use clindamycin with diphenoxylate, loopamid or opiat (anti -peristalsis) because these drugs can worsen colitis syndrome due to clindamycin.

Do not be used with the Kaolin - pectin mixture because of reducing the absorption of clindamycin.

Storage

In a dry, cool place (below 30 ° C). Avoid light.

Other drugs

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