Pyfaclor 500mg pymepharco treatment for otitis media, respiratory infections (1 blister x 12 tablets)

Dosage form Box of 1 blister x 12 tablets
Specifications Cefaclor

Ingredient

Composition information	Content
Cefaclor	500mg

Uses

Indications

Pyfaclor 500 mg is indicated in the following cases:

Treatment of infections caused by sensitive bacteria: otitis media , respiratory infections, including sore throat. drink. The drug has a bactericidal effect due to synthetic inhibition of mucopeptide into bacterial cells.

In vitro tests show that Cefaclor works for bacterial strains: Staphylococcus including strains producing penicillinase, positive, negative coagulase; Streptococcus Pneumoniae, Streptococcus Pyogenes, (Streptococcus Beta Group A); Moraxella Catnrhalis, Haemophilus Influenzae (including strains producing beta lactamase, ampicillin resistance); Escherichia coli; Proteus Mirabilis; Klebsiella spp; Citrobacter Diversus, Bacteroides spp. (except bacteroides fragilis); Neisseria gonorrhoeae.

pharmacokinetic

cefaclor is absorbed very well after drinking. The total number of medications is the same whether patients are hungry or full. However, when used with food, the peak concentration is only 50-70% compared to the peak concentration when the patient is fast and is slower about 45 - 60 minutes. After taking the dose of 250 mg, 500 mg and 1 g in hunger, the average peak concentration in serum corresponds to 7 mg/l, 13 mg/l and 23mg/l, achieved after 30-60 minutes.

The drug is widely distributed to the body's tissues. About 25% of the drug associated with plasma proteins. The average half -life of serum cancellation in normal people is about 1 hour (from 0.6 to 0.9 hours).

In patients with impaired renal function, the half -life is often a bit longer.

In patients completely impaired renal function, the half -life of serum cancellation of the original drug is 2.3 - 2.8 hours.

Dialysis reduces the sale time of drugs by about 25 - 30%.

Before taking Pyfaclor 500mg pymepharco treatment for otitis media, respiratory infections (1 blister x 12 tablets)

How to use

Pyfaclor 500 mg oral, oral, orally.

Dosage

Adults:

Normal dose 250 mg every 8 hours. Maximum dose of 4 g/day.

Sore throat, bronchitis, tonsillitis, skin and soft tissue infections, urinary tract infections below the dose 250 - 500 mg, twice a day or 250 mg, 3 times a day.

For more severe infections: dose of 500 mg, 3 times a day.

To treat gonorrhea due to gonorrhea: The only dose of 3 g combined with 1 g of probenecid.

Patients with renal failure:

Mild to moderate renal function: No dose adjustment.

Cases of severe renal failure: If the clearine clearance 10 - 50 ml/min, use 50% of the common doses. If creatinine clearance is below 10 ml/min, use 25% of the common doses.

Patients have to climb hematoma:

When the hemorrhage, half -life of Cefaclor in serum decreased by 25 - 30%. Therefore, for patients who have to hemorrhage regularly, the starting dose should be used 250 - 500 mg every 6-8 hours, during the time between the separation.

Children:

Normal dose 20 mg/kg/day, divided into oral oral every 8 hours.

For bronchitis and pneumonia: take a dose of 20 mg/kg/day divided into 3 times. In case of more severe infections, 40mg/kg/day can be used in several times. Maximum dose of 1 g/day.

When using drugs in children, it is necessary to choose the appropriate preparation form.

With the dose division (using a hard capsules of 250 mg Cefaclor or Cefaclor nuggets to divide the dose accordingly).

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Signs and symptoms

After overdose, the patient has symptoms: nausea, vomiting, epigastric pain, diarrhea. The level of epigastric pain and diarrhea depends on the dose. If there are other symptoms, it may be due to the secondary reaction of a hidden disease, an allergic reaction or other poisoning effects.

Treatment

Treatment of symptoms and use measures to support the total weight, including maintenance of the air, blood gas and serum electrolyte. Can use activated carbon. Strong diuretic should not be taken, peritoneal, dialysis or dialysis with active carbon to treat overdose. Except for the case of 5 times the dose of normal, no need to apply gastrointestinal measures.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using pyfaclor 500 mg , you may experience unwanted effects (ADR).

Common, ADR> 1/100

Blood: Eosin hypernagus.

Systemic: Test Coombs directly positive.

Digestive: Nausea, vomiting.

Skin: itching, urticaria.

Body: Anaphylaxis, fever, Stevens - Johnson syndrome , Lyell syndrome. The serum is more common in children than adults: diverse rash, inflammation or joint pain, fever or no, may be accompanied by enlarged lymph nodes, proteinuria.

liver: Increased liver enzyme, hepatitis and jaundice.

kidney: interstitial nephritis, slight increase in blood urea or serum creatinine or abnormal urine tests.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Pyfaclor 500 mg contraindicated in the following cases:

Patients with antibiotics of cephalosporin groups.

Children under 1 month of age.

Caution when using

Caution used for patients with a history of hypersensitivity to penicillin.

Be careful when using Cefaclor for patients with severe renal impairment.

Patients with gastrointestinal diseases, especially patients with colon.

The ability to drive and operate machinery

cefaclor does not affect the ability to drive and operate machinery. However, some rare cases can cause headaches, dizziness, and sleep. Therefore, patients use drugs should be cautious when driving and operating machinery.

Pregnancy

only used for pregnant women when really necessary.

Breastfeeding period

only used for breastfeeding women when essential.

Drug interaction

Probenecid slowed down Cefaclor's excretion.

Cefaclor's absorption is reduced if used with antacids containing aluminum hydroxid or magnesium hydroxid within 1 hour.

cefaclor causes prolonged prothrombin time.

Storage

In a dry, cool place (below 30 ° C). Avoid light.

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