Pymme-AM10 pymepharco treatments for idiopathic hypertension (2 blisters x 15 tablets)

Dosage form Box of 2 blisters x 15 tablets
Specifications Amlodipine

Ingredient

Composition information	Content
Amlodipine	10mg

Uses

indications

Pymme AM10 is indicated for treatment in the following cases:

Treatment of idiopathic hypertension.

Calcium inhibitors passing through the heart cells and smooth muscles of blood vessels by preventing slow calcium channels of cell membranes.

Thanks to the effect of the drug, the smooth muscle tone of the blood vessels (the arteries) decreases, thereby reducing the peripheral resistance that leads to hypotension.

The drug has an anti -angina effect mainly by relaxing peripheral arteries and reducing the back burden.

The consumption of energy and oxygen needs of the heart muscle decreases because the drug does not cause reflection of tachycardia.

Coronary dilatation drugs increase oxygen supply for myocardial muscle.

Dynamic pharmacokinetics

Biological comfort of amlodipine when drinking about 60 - 80% and not affected by food.

Peak concentration in plasma is achieved after taking the recommended dose for 6 to 12 hours. Half life in plasma from 30 - 40 hours.

Peak concentration in plasma reaches 7 to 8 days after taking the drug once a day.

The integral distribution is approximately 21 liters/kg body weight and drugs linked to protein - high plasma.

The plasma clearance is normal at about 7 m/min/kg body weight due to excretion mainly through metabolism in the liver. The metabolites are inactive and excreted through the urine.

Before taking Pymme-AM10 pymepharco treatments for idiopathic hypertension (2 blisters x 15 tablets)

How to use

Pymme AM10 tablets for oral tablets.

Dosage

Adults: Treatment of angina and high blood pressure at the starting dose is usually 5mg/time/day. It can be increased until the maximum dose is 10mg depending on the response of the patient.

Patients with risk of liver failure.

No need to adjust the dose when used simultaneously with thiazide diuretics, inhibitors, and enzyme inhibitors.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when overdose?

In case of an overdose with calcium blockers, the general treatment is as follows:

Monitor cardiovascular disease with electrocardiograms and treat symptoms of effects on cardiovascular effects along with gastric lavage and active carbon drinking. If you need to adjust the electrolytes.

In case of bradycardia and heart heart, atropine injection must be injected with an Atropine 0.5-1 mg into the vein for adults (for children, intravenously 20-50 micrograms/kg body weight). If you need to repeat the injection.

Intravenous injection 20 ml of calcium gluconate solution (9 mg/ml) for 5 minutes for adults isoprenalin 0.05 - 0.1 microgram/kg/minute or adrenalin 0.05 - 0.3 microgram/kg/minute or dopamine 4 microgram/kg/min.

For patients with reduced circulatory volume, 0.9%sodium chloride solution is required. When you need to place the pacemaker.

In case of severe hypotension, intravenously 0.9%sodium chloride solution, adrenalin.

If not effective, use isoprenalin in combination with amrinone. Symptomatic treatment.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

Unwanted effects when using PYME AM10 that you may encounter.

Frequently responded to the body such as ankle edema from mild to moderate related to the dose, headache, dizziness, flushing and feeling of barrel, fatigue, weakness; Brush the chest drum; cramps; Digesting such as nausea, abdominal pain, indigestion, shortness of breath.

Less: excessive hypotension, tachycardia, chest pain; Output, itching, muscle pain, joint pain, sleep disorders.

Rarely: extra mind; Increase productivity; urticaria; Increase liver enzyme; Increase blood glucose, confusion, diverse roses.

Notice the unwanted physician when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Pymme AM10 is contraindicated in the following cases:

Contraindicated in patients with hypersensitivity to amlodipine or dihydropyridine derivatives or any ingredients of the drug.

Be cautious when using

with people who reduce liver function, artery stenosis, heart failure after acute myocardial infarction.

The ability to drive and operate machinery

Persons who often drive or operate machinery should use drugs?

Do not use drugs when driving and operating machinery.

Women during pregnancy and lactation

Women during pregnancy should take medicine?

Calcium channel blockers can inhibit uterine muscles early.

However, the drug has no adverse effects on the delivery process. The risk of oxygen deficiency must be taken into account if causing hypotension in the mother, because there is a risk of reducing placental perfusion. This is a common risk when using hypertension medications, they can change the blood flow due to peripheral vasodilation.

In experimental animals, calcium channel blockers can cause teratogenic bone deformities. Therefore, avoid using amlodipine for pregnant women, especially in the first 3 months of pregnancy.

Should

Women breastfeeding should take medicine?

There has been no notice to evaluate the accumulation of amlodipine in breast milk.

Drug interaction

drug interactions may affect the activity of the drug or cause side effects. Should notify the doctor or pharmacist a list of drugs and functional foods you are using. Do not use or increase or decrease the dose of the drug without the guidance of a doctor.

Non -steroid anti -inflammatory drugs: Studies show that amlodipine is used safely with nonsteroidal anti -inflammatory drugs but can reduce the hypotension of amlodipine, especially indomethacin due to the inhibition of prostaglandin synthesis in the kidneys and/or cause na and water to keep na and water.

estrogen: estrogen causes water so it tends to increase blood pressure.

Sympathetic nerve stimulants: reducing the hypotension effect of amlodipine.

Anesthesia: Increases the anti -hypertension effect of amlodipine and can make blood pressure more sharply.

Lithi: When used with amlodipine, it can cause nerves, nausea, vomiting, diarrhea.

High -linked drugs with protein (such as Coumarin, Hytantoin ...) must be used to be careful with amlodipin, because amlodipine is also highly linked to protein, the concentration of the above drugs is free (non -linked), can change in serum.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

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