Pymme Fucan Pymepharco treats Candida Fungal infection (20 boxes x 1 tablet)

Dosage form Box of 20 boxes x 1 tablet
Specifications Fluconazole

Ingredient

Composition information	Content
Fluconazole	150mg

Uses

Indications

Pymme fucan is indicated in the following cases:

Treatment of Cryptococcus meningitis, treatment for the prevention of Cryptococcus disease in AIDS patients. Agency and relapse and prevent recurrence of vaginal candidiasis. In patients with HIV infection. Fluconazole has an anti -fungal effect due to changing cell membranes, increases cell membranes, escapes essential factors and reduces the import of precursor molecules.

fluconazole acts by selecting Cytochrom P45014 - Alpha - Demethylase, preventing the synthesis of Ergosterol as sterol mainly in the fungal cell membrane. Demethyl chemical cells in mammals are less sensitive to fluconazol's inhibition. The common sterol of sterols later correlated with the accumulation of 14 - Alpha - methyl sterol in mushrooms and can meet the mushroom pliers of fluconazol.

Used in severe specialized contamination of Candida fungi without resistance to fluconazole, in addition to the case of coccidioides immitis infection, histoplasma.

pharmacokinetics

In conventional patients, oral bioavailability of over 90% of intravenous injection. The maximum concentration in plasma is achieved within 1-2 hours, the stable concentration is achieved within 5-7 days. Patients with a single dose of 400mg with an average peak concentration of 6.72µg/ml (between 4.12 - 8.08µg/ml).

The only dose of 150mg capsules in 10 women breastfeeding CMAX results averages 2,61Ug/ml (between 1.57 to 3.65μg/ml). Stable concentration achieved in 5 - 10 days when used orally dose 50 - 400 mg daily.

Fluconazole is excreted mainly through the kidneys, about 80% of the dose appears in urine in constant form, about 11% of the dose found in urine in metabolic forms.

The drug is widely distributed in tissues and fluid fluids. The concentration of breast milk, joint fluid, saliva, sputum, vaginal fluid and peritoneal fluid similar to plasma concentrations. The concentration in cerebrospinal fluid reaches 50% - 90% of plasma concentrations even when the meninges are not inflamed. Protein ratio is about 12%. Half life eliminates about 30 hours, and increases in kidney failure. The drug is also eliminated by a separation.

Before taking Pymme Fucan Pymepharco treats Candida Fungal infection (20 boxes x 1 tablet)

How to use

oral drugs.

Dosage

Adults

Cryptocoocus meningitis

The starting dose of 400mg/day the first day. Then 200mg/day, use at least 6-8 weeks.

Cases of recurrent prevention due to cryptococcus

Dosage 100 - 200mg/day.

For blood candidiasis, scattered candidiasis and other types of invasive candidiasis infections

The usual dose of 400mg on the first day, then 200mg per day.

Vaginal candidiasis, foreskin caused by Candida

Single dose 150mg.

Candida fungus pharynx

Use 50 - 100mg/day for 1-2 weeks. To prevent the recurrence of the mouth and mouth Candida, the throat in AIDS patients, after completing the initial treatment, can be used at a dose of 150mg once a week.

Fungal fungal infections, thigh skin fungus, nail mushrooms

Use 150mg/Irel/week.

For worms

Can take the dose of 200 - 400mg/day, the treatment time depends on each person but lasts from 11 - 24 months with Coecidioides Immitis infection, 3 - 17 months for Histoplasma.

Patients with renal failure

No need to adjust the dose in case of a single dose.

Long -term treatment in patients with renal failure

should start the treatment dose with an attack dose of 50 - 400mg. After that, you must adjust the time between 2 doses or dose according to creatinine clearance as follows:

Creatinine clearance> 50ml/min: Normally every 24 hours.

Creatinine clearance 11 - 50ml/min: Normal dose every 48 hours or half a usual dose every 24 hours.

Patients with regular appraisal patients: A common dose after each appraisal.

Children

Backup

Use 3mg/kg/day in surface fungal infections and 6 - 12mg/kg/day in systemic fungal infections.

In persistent cases may need 12mg/kg/24 hours, divided into 2 times.

Do not use more than 600mg per day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

fluconazole is strongly eliminated in urine. Therefore, increasing pressure diuretic can increase the rate of elimination.

Dialysis jurors for 3 hours reduces the plasma content of fluconazole to about 50%.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Pyme Fucan, you may experience unwanted effects (ADR).

Common

headache, nausea, vomiting, diarrhea, abdominal pain.

Transient transaninase and serum bilirubin.

rash, itching.

Rare

Blood: Eosin hypernagus, anemia, leukemia, neutropenia, platelets.

liver: increasing the concentration of transaminase in serum and must stop the drug. Skin: Skin flaky (mainly in AIDS and cancer), Stevens - Johnson syndrome.

Other symptoms

Fever, edema, pleural effusion, little urine, hypotension, hypotension, anaphylaxis.

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Pymme fucan is contraindicated in the following cases:

Patients with hypersensitivity to the ingredients of the drug, the compounds of the Azol group.

Unused with terfenadine in patients using fluconazol.

Pregnant women, except for serious fungal infections threatening life.

Lactating women.

Precautions when using

Insert the kidney or liver function.

Should stop treating fluconazole if the symptoms of liver disease occur.

Caution should be monitored while treating fluconazol in immunosuppressive patients.

The ability to drive and operate machinery

fluconazole does not affect the ability to drive and operate machinery.

Pregnancy

pregnant women are not used, unless serious fungal infections threaten life.

Breastfeeding period

fluconazole through breast milk with the same concentration as in plasma, so it should not be used in nursing women.

Medicinal interaction

simultaneous use of fluconazole and phenytoin may increase the level of phenytoin in plasma.

Fluconazole can extend the half -life in serum when used simultaneously with sulfonylurea (chlorpropamide, glibenclamide, glipizide, tolbutamine).

rifampicin reduces the absorption and half -life of fluconazole, so when used simultaneously with rifampioin, the dose adjustment of fluconazol is needed.

Storage

In dry, cool, temperature below 30 ° C. Avoid light.

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