Pyrazinamide 500mg Mekophar medicine for tuberculosis (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Pyrazinamide

Ingredient

Composition information	Content
Pyrazinamide	500mg

Uses

Indications

Pyrazinamide 500mg is indicated in the following cases:

Treatment of new tuberculosis diagnosis or re -treating tuberculosis and outside the lungs, mainly at the initial attack stage, often in combination with other anti -tuberculosis drugs.

Pyrazinamide has the effect of killing mycobacterium tuberculosis, which exists in the acidic intracellular environment of the macronal.

Dynamic pharmacokinetics

absorption

Pyrazinamide is well absorbed through the gastrointestinal tract. The peak concentration in the serum reaches 2 hours after taking a dose of 1.5 g of about 35 mg/ml and with a dose of 3 g of 66 mcg/ml.

distribution

The drug is widely distributed into the body's tissue and fluid including the liver, lungs, cerebrospinal fluid.

pyrazinamide is attached to 10%mineral plasma proteins. The half -life of the drug is 9 - 10 hours, lasting longer in liver failure or kidney failure.

transformation

pyrazinamide is hydrolyzed in the liver into the main metabolic substance that is active as pyrazinoic acid, which is then hydroxylated into 5-hydroxyyrazinoic acid.

Elimination

The drug is excreted through the kidneys, mainly due to the filtration of the glomeruli, about 70% of oral dose excreted within 24 hours.

Before taking Pyrazinamide 500mg Mekophar medicine for tuberculosis (10 blisters x 10 tablets)

How to use

pyrazinamide 500mg tablets for oral tablets.

Dosage

Dosage: According to the doctor's instructions.

The dose is often used for both adults and children:

20 - 30 mg/kg day when treated daily.

30 - 40 mg/kg/day when treating distance, 3 days.

40 - 60 mg/kg/day when treating distance, 2 days week.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? This spontaneous increase returns to normal when stopping the drug.

Handling: gastric lavage, supportive treatment. Can be differentiated to eliminate pyrazinamide.

If the overdose occurs, it is recommended to go to the nearest medical facility for medical staff to have treatment methods.

What to do when you forget a dose?

If you forget a dose, use it as soon as possible. However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Pyrazinamide 500mg, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Hepatitis: hepatitis.

metabolism: increased blood uric acid that can cause gout attacks.

musculoskeletal joints: pain in large and small joints.

Uncommon, 1/1000

musculoskeletal joints: arthritis .

rare, 1/10,000

Digestive: nausea, vomiting, anorexia.

Metabolism: Porphyrin metabolism.

Kidney: difficulty urinating.

Skin: Sensitive light, itching, rash.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Pyrazinamide 500mg contraindicated in the following cases:

Sensitive to any ingredients of the drug.

Severe liver damage.

Porphyrin metabolic disorders.

acute gout.

Caution when used

To avoid anti -drug mutant bacilli in the treatment of tuberculosis, do not use a drug (single therapy) but must have a combination of pyrazinamide with other effects, especially in the initial attack treatment period.

Caution for people with a history of diabetes, arthritis, history of acute gout, renal failure.

The ability to drive and operate machinery

has not seen the drug that affects the ability to drive and operate the machine.

Pregnancy

Pregnant women only use pyrazinamide when really necessary.

breastfeeding period

pyrazinamide secreted into breast milk in small amounts, cautious when taking this medication in nursing women.

Medicinal interaction

pyrazinamide increases blood uric acid and reduces the effectiveness of gout medications such as Allopurinol, Colchicine, Probenecid, SulfinPyrazone. Need to adjust the dose of these drugs when used simultaneously with pyrazinamide.

pyrazinamide reduces cyclosporine concentration when used simultaneously. Cyclosporine concentration must be monitored in serum

Storage

In a dry place, avoid light, the temperature does not exceed 30 ° C.

Mekophar Pharmaceutical - Pharmaceutical Joint Stock Company was established in 1975. Currently, the company is operating in the fields of production and business, import and export of pharmaceuticals, pharmaceuticals, chemicals, raw materials for the pharmaceutical industry, medical tools, traditional medicine and stem cell banks.

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