QAPANTO Atlantic medicine reduces the recurrence of duodenal and stomach ulcers (6 blisters x 10 tablets)

Dosage form Box of 6 blisters x 10 tablets
Specifications Pantoprazole

Ingredient

Composition information	Content
Pantoprazole	40mg

Uses

indications

QAPATTO drug is indicated in the following cases:

Helicobacter pylori treatment in patients with stomach ulcers to reduce stomach and duodenal ulcers caused by using this drug in combination with two appropriate antibiotics. Severe.

Pantoprazol is converted into active metabolic activity in the acidic environment of the stomach into the stomach due to inhibiting H+, K+ - ATPASE inhibiting the final stage of the production of hydrochloric acid. The inhibition of pantoprazol depends on the dosage and has simultaneous impact on the basic excretion process and increases the production of hydrochloric acid. On most patients, symptoms will improve after 2 weeks.

As with other H2 receptor inhibitors and inhibitors, the treatment with pantoprazol can cause a decrease in gastric acid secretion and thus increases the galastin levels in the ratio of acid reduction. Gastrin increased process is reversible. Because Pantoprazol is attached to the enzyme far away from the surface cell receptor, it can independently act on the excretion of hydrochloric acid of other stimulants such as acetylcholine, histamine, gastrin and this effect is the same if using pantoprazol in oral or intravenous form.

Pharmacokinetics

absorption

Pantoprazol is quickly absorbed and reaches the maximum concentration in plasma only after taking a single dose of 40mg. On average, about 2-2.5 hours after taking the drug, the drug reaches the maximum concentration in the serum is 1-1.5μg/ml, this concentration remains the same after many treatments. The distribution volume is about 0.15l/kg and the clearance of about 0.1 l/h/kg.

The last half of the semi -waste of the drug is about 1 hour. There are only a few cases of slow elimination. Due to the selective chemical impact of Pantoprazol in the cover cells, half -life excreted time of non -linear activity with the time of prolonged impact of the drug (inhibitors of gastric acid excretion).

The pharmacokinetics of the drug does not change after the single dose or reminded treatment. At a dose of about 10 to 80mg, the plasma dynamics of Pantoprazole are almost linearly when oral and intravenous treatment.

Distribution

Pantoprazol ratio combined with serum protein is about 98%.

Metabolism

The active ingredient is almost completely metabolized in the liver. The main metabolites both in serum and kidneys are desmethylpantoprazol - the metabolic form due to the sulfate combination.

Elimination

The metabolic forms of pantoprazol excreted mainly in the kidneys (accounting for 80%), the rest is excreted in feces. Half lifetime elimination of main metabolites (about 1.5 hours) is not much longer than half a lifetime elimination of pantoprazol.

Before taking QAPANTO Atlantic medicine reduces the recurrence of duodenal and stomach ulcers (6 blisters x 10 tablets)

How to use

Do not chew or crush pantoprazol but must take whole tablets with water, an hour before breakfast. In Helicobacter Pylori, need to take the second pantoprazol tablet before dinner.

Dosage

In patients with stomach and duodenal ulcers, Helicobacter pylori infection (positive), need to kill bacteria by combined therapy. Depending on the type of drug resistance, recommend the coordination treatment regimens as follows:

Regimen 1: 2 times a day x (1 pantoprazol + 1000mg Amoxicillin + 500mg Clarithromycin). + 1000mg Amoxicillin + 500mg metronidazol).

duodenal ulcer, gastric ulcer and reflux esophagitis, most of the usual doses 1 pantoprazol daily. In special cases, double dosage can be increased (every day to 2 pantoprazol), especially those who do not respond to other drugs.

In long-lasting control treatment for Zollinger-Elison syndrome and the situation of increased diseases of pathology, patients should start treatment at a dose of 80mg/day (2 tablets/day). Then increase or decrease the dose as required by measuring the concentration of gastric acid secretion to orient. With a dose of over 80mg/day, it is necessary to divide and take medicine 2 times. The temporary dose may be increased over 160mg/day but not treated longer than the necessary time for stomach acid to be adjusted.

There is no restriction on the treatment time for Zollinger-Elison syndrome and the situation of increased disease secretion, so adjust the time appropriate to the treatment needs.

For patients with severe liver failure, the dose should be reduced to 2 days 1 tablet 40 mg pantoprazol). In addition, while using pantoprazol, the liver enzyme should be monitored, if the liver enzymes increase, they must stop taking the drug immediately.

For elderly people or kidney failure, do not overdose pantoprazol 40mg. Except for the case of using a combination therapy to kill H.pylori, then pantoprazole must be used twice as much as the usual dosage (2x40mg/day) in a week of treatment.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when using overdose? In case of overdose and clinical poisoning symptoms, the application of common detoxification rules.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using QAPANTO drugs, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive system: upper abdominal pain, diarrhea , constipation or flatulence.

Nervous system: headache .

The digestive system: Nausea, vomiting.

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

anti -contraindications in the following cases:

Do not use Pantoprazol for cases where there is a history of sensitivity to any ingredient of the drug or any drug used in coordinated treatments. Destroy H.P in these patients.

Be cautious when using

do not indicate pantoprazol for mild digestive disorders such as nervous indigestion.

In the drug combination therapy, it is necessary to pay attention to the characteristics of the combined drug.

Before treatment with Pantoprazol, it is necessary to eliminate the possibility of malignant stomach ulcers or malignant esophagitis, because treatment with Pantoprazol can temporarily lose symptoms of malignant ulcer, so it can slow down the diagnosis of cancer.

Diagnosis of reflux esophagitis should be confirmed by endoscopy.

There is no experience in treating Pantoprazol in children.

For patients with Zolliger-Elison syndrome and the condition of increased diseases that need long-term treatment, Pantoprazole is like other acidic blockers, which can reduce the absorption of vitamin B12 (cyanocobalamin) caused by reduced or no acid secretion. This should be noted when there are clinical symptoms in each individual.

The ability to drive and operate machinery

is currently unclear the effect of the drug when used for drivers or operating machinery.

Pregnancy

Clinical experience of pantoprazol when used during pregnancy is limited. In animal reproduction studies, the signs of toxicity on the mild fetus are recorded in bureaucracy above 5 mg/kg.

The period of breastfeeding

There is no information on pantoprazol excretion through breast milk. Therefore, only using pantoprazol when the benefit of the mother is considered greater than the risk of the fetus and the baby.

Drug interaction

pantoprazole may reduce the absorption of drugs that depend on pH (for example, ketoconazole).

The active ingredient of pantoprazol is metabolized in the liver by the cytochrom P450 enzyme system. It does not exclude the possibility of pantoprazole interacting with other drugs metabolic and cytochrom P450 enzyme system. However, the clinical clinical has not seen significant interaction in specific tests with some of the above -mentioned drugs or compounds, such as carbamazepin, caffeine , diazepam, diclofenac, digoxin , ethanol, glibenclamid, metoprolol, nifedipine Phenytoin, Theophyllin , warfarin and oral contraceptives.

Do not observe drug interactions when treated simultaneously with phenprocoumon and warfarin in clinical pharmacokinetic studies, there are very few cases of changes in the rate of ordinary chemicals of INR stated in the drug circulation report when coordinated treatment. Therefore, in patients treated with Coumarin -style anticoagulants, prothrombin/INR is required to monitor the ratio of prothrombin/INR when starting, finishing or when there is an abnormal treatment with pantoprazol.

also do not see pantoprazole interacting with antacids (treat stomach pain) when taken at the same time.

There is no interaction with combined antibiotics (clarithromycin, metronidazol, amoxicyllin ) in the treatment of Helicobacter pylori.

Storage

Store in closed packaging, at temperatures below 30 ° C.

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