Queitoz-200 Davipharm treatment of schizophrenia (4 blisters x 7 tablets)

Dosage form Box of 4 blisters x 7 tablets
Specifications Quetiapine

Ingredient

Composition information	Content
Quetiapine	200mg

Uses

Indications

Queitoz - 200 drugs are indicated in the following cases:

Schizophrenia treatment.

Treatment of bipolar disorders.

Pharmacy

Quetiapin is an inappropriate anti -psychotic drug. Quetiapin and metabolites are active in plasma, N - Desalkyl Quetiapin, which acts on many types of neurotransmitter receptors. Quetiapin and N - Desalkyl Quetiapin have a affinity for serotonin receptors (5ht2) in the brain and with Dopamine D1 and D2 receptors. It is the selection with a higher Serotonin receptor (5HT2) in the brain with Dopamine D2 receptor that is believed to contribute to the clinical anti -psychotic properties and have little risk of unwanted effects on the outskirts of Quetiapin.In addition, N - D - Desalkyl Quetiapin has high affinity with norepinephrin transportation (Net). Quetiapin and N - Desalkyl Quetiapin also have high affinity with histaminergic and adrenergic alpha 1 receptors, with lower affinity with adrenergic alpha 2 receptors and 5HT1A Serotonin. Quetiapin has negligible affinity for the Cholinergic Muscarinic or Benzodiazepin receptors.

pharmacokinetic

quetiapin is well absorbed and completely transformed after drinking. Quetiapin's bioavailability is not significantly affected by food. Quetiapin binds about 83% to plasma protein. The maximum concentration in the stable state of metabolites is activated N - Desalkyl Quetiapin equal to 35% of this concentration of Quetiapin. The sale time of Quetiapin and N - Desalkyl Quetiapin in the order is about 7 and 12 hours. Quetiapin and its metabolites are eliminated through feces (20%) and urine (73%).

Before taking Queitoz-200 Davipharm treatment of schizophrenia (4 blisters x 7 tablets)

How to use

queritoz drugs are used for oral.

Dosage

Adults

schizophrenia

Should drink quetiapin twice a day, during or outside the meal. The total daily dose in the first 4 days of treatment is 50 mg (daily 1), 100 mg (dated 2), 200 mg (dated 3) and 300 mg (dated 4). From the 4th day onwards, the dose adjustment should be effective from 300 to 450 mg/ day. Depending on the clinical response and tolerance of each patient, the dose can be adjusted in the range of 150 to 750 mg/day.

Treatment of bipolar disorder

Should drink quetiapin twice a day, during or outside the meal. Single therapy or support for medications stabilizing the mental state, the total daily dose per day in the first 4 days of treatment is 100 mg (daily 1), 200 mg (dated 2), 300 mg (dated 3) and 400 mg (dated 4). The dose can be gradually adjusted to 800 mg/day on the 6th day but each increase should not exceed 200 mg/day. The dose can be adjusted depending on the clinical response and tolerance of each patient, between 200 to 800 mg/day. The usual dosage has a treatment effect of 400-800 mg/day.

Elderly

Like other anti -psychotic drugs, should be cautious when using Quetiapin in the elderly, especially in the starting stage of using the drug. Elderly patients should start with Quetiapin 25 mg/day. Should increase the dose every day, each level of 25 to 50 mg, to the dose to achieve effective treatment, usually lower than the dose effectively treated in young patients.

children and adolescents

Safety and effectiveness of Quetiapin for children and minors has not been evaluated.

Patients with liver failure and kidney failure

Oral Quetiapin clearance decreases by about 25% in patients with liver failure or renal failure. Quetiapin is metabolized mainly in the liver and therefore should be used carefully in patients with liver failure. Patients with liver or renal failure should start with quetiapin 25 mg/day. Should increase the dose every day, each level of 25 to 50 mg, to the dose to achieve effective treatment.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? Most of the overdose patients have no adverse events or complete recovery from the recorded events. The death of death in a clinical trial after an overdose of 13.6 g Quetiapin (not in combination with other drugs). After bringing the drug to the market, in case of reporting the overdose of Quetiapin (non -coordinating drugs) death or coma is very rare. Patients who have suffered from severe cardiovascular disease may increase the risk of overdose.

In general, the signs and symptoms are due to increased pharmacological effects of the drug, such as vaginal and sedative, tachycardia and hypotension.

There is no specific detoxification for Quetiapin. In case of severe poisoning, it is necessary to consider the ability of many drugs, taking special care measures, including establishment and maintenance of airway, ensuring ventilation and adequate oxygen supply, monitoring and cardiovascular support, need to continue monitoring and monitoring patients strictly until complete recovery.

What to do when forgetting a dose? If it is nearly time to take the next dose, skip the forgotten dose and take medicine at the next recommended dose. Do not take double dose to compensate for the forgotten dose.

Side Effects

When using queitoz - 200, you may experience unwanted effects (ADR).

Sleep, dizziness, dry mouth, mild weakness, constipation, tachycardia, hypotension, and indigestion.

Fainting, malignant neurolithic syndrome, leukopenia, neutropenia and peripheral edema, hyperglycemia, weight gain may occur.

Very common, ADR> 10%

Nervous system dysfunction: dizziness, dizziness, drowsiness.

Common, 1% ≤ ADR

Nervous system dysfunction: fainting.

Respiratory, chest and medical disorders: rhinitis.

Disorders of blood system and lymph: leukopenia.

Heart dysfunction: tachycardia.

Vascular dysfunction: Hypotenary pressure vertical.

Disorders of the digestive system: dry mouth, constipation, indigestion.

Side effects on the spot and whole body: mild weakness, peripheral edema. Subclinical: weight gain, serum transaminase (ALT, AST).

Neutral leukopenia.

Hematoma increases to the level of pathology.

Uncommon, 0.1% ≤ ADR

Bloody and lymphatic dysfunction: Multi -kind white blood cells.

Immune system dysfunction: Hypersensitivity.

Clinical: increasing gamma - GT4, increasing serum triglycerides at any time, increasing total cholesterol (mainly LDL - C).

Nervous system dysfunction: convulsions, tremor syndrome.

Rare, 0.01 % ≤ ADR

Side effects on the spot and whole body: Malignant neuropular syndrome.

Genital dysfunction: erectile dysfunction.

Very rare, ADR

Immune system disorders: Anaphylactic reaction.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Queitoz - 200 contraindications in case of hypersensitivity to any ingredients of the drug.

Precautions when using

has recorded the asymptomatic transformation of lens in patients with long -term treatment with Quetiapin. Carteches have occurred in dogs in long -term tests. The patient is recommended to check the eye to detect signs of cataract at the beginning of treatment with Quetiapine and every 6 months during treatment.

Quetiapin should be used carefully in patients with liver failure, kidney failure, patients with cardiovascular disease or conditions that can lead to hypotension, patients with cerebrovascular disease, patients with epilepsy or epilepsy or conditions may reduce epilepsy threshold.

When Quetiapin is used to treat depression in bipolar disorders, patients must be carefully monitored during the early stages of treatment until observing the significant improvement of depression, because suicide is the risk of inherent in depression patients.

Neutral leukemia

Heavy neutropenia (

Hyperglycaric blood glucose

Having acknowledges blood glucose and several diabetes reports in clinical trials with quetiapin. Although the causal relationship with diabetes has not been established, patients at risk of diabetes are advised to be appropriate clinical monitoring. Similarly, it is advisable to monitor the plays that can occur in patients with diabetes.

Cardiovascular disease:

Quetiapin should be used carefully for patients who know that there is cardiovascular disease, cerebrovascular disease, or other pathological conditions that can cause hypotension. Quetiapin can cause vertical hypotension, especially in the first stage of dose adjustment; Often occurs in older patients in young patients. In clinical trials, Quetiapin is not related to an increase in QT. However, like other anti -psychotic drugs, should be cautious when prescribing Quetiapin simultaneously with the known drugs that extend the QT range, especially in the elderly patients.

convulsions

In control clinical trials, there is no difference in the frequency of epilepsy between the group of patients using Quetiapin and the placebo group. Like other anti -psychotic drugs, should be cautious when using drugs for patients with epilepsy history.

Late movement disorders

As well as other anti -psychotic drugs, Quetiapin can cause late movement disorders when prolonged treatment. When there are any signs or symptoms of late movement disorders, should consider reducing the dose or stop quetiapin.

Malignant neuropular syndrome

Malignant neuropular syndrome is related to the treatment of anti -psychotic drugs, including Quetiapin. Clinical manifestations include overcrowding, mental changes, muscle spasms, unstable autonomous nervous systems and increased creatin phosphokinase. In this case, Quetiapin should be discontinued and appropriate treatment.

Reaction due to sudden stopping drugs

Symptoms of nausea, vomiting and insomnia are rare when sudden stopping anti -psychotic drugs. Relapse of mental symptoms can also occur, and the appearance of unintentional movement disorders (such as not sitting still, muscle disorders and movement disorders) have been recorded. Therefore, it should be stopped slowly.

Elderly patients with intellectual decline

Quetiapin has not been approved to treat patients with mental disorders related to dementia. In a synthetic analysis (Meta - Analysis) for typical anti -psychotic drugs, there was a report on increased risk of death in elderly patients with psychotic disorders associated with dementia compared to placebo.

The ability to drive and operate machinery

Because Quetiapin can cause drowsiness, patients need to be cautious when operating the machine, including driving.

Pregnancy

Quetiapin's efficiency and safety for pregnant women has not been established. Therefore, Quetiapin should only be used during pregnancy when the benefits are out of the risks that may occur.

Breastfeeding period

is unknown to the extent of quetiapin into breast milk. Therefore, women should stop breastfeeding while using Quetiapin.

Drug interaction

Increased risk of drowsiness and hypotension when used with alcohol.

CYP3A4 enzyme induction such as phenytoin and carbamazepine may reduce the plasma concentration of quetiapin.

CYP3A4 enzyme inhibitors such as ketoconazole and erythromycin may increase the plasma concentration of quetiapin.

Storage

In a dry place, avoid light, the temperature does not exceed 30 ° C.

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