Queitoz-50 Davipharm Treatment of schizophrenia, bipolar disorder (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Quetiapina

Ingredient

Composition information	Content
Quetiapina	50mg

Uses

Indications

queitoz 50mg pills are indicated in the following cases:

Treatment schizophrenia .

Treatment bipolar disorder .

quetiapin and metabolites are active in human plasma, N - Desalkyl Quetiapin has the effect on many types of neurotransmitter receptors.

Quetiapin and N - Desalkyl Quetiapin have a affinity for serotonin receptors (SHT2) in the brain and with Dopamine D1 and D2 receptors. It is the selection with the higher Serotonin receptor (SHT2) with the Dopamine D2 receptor that is believed to contribute to the clinical anti -psychotic properties and have little risk of unwanted effects on Queitoz's foreign tower system.In addition, N - D - Desalkyl Quetiapin has high affinity with norepinephrin transportation (Net). Quetiapin and N - Desalkyl Quetiapin also have high affinity with histaminergic and Adrenergic alpha1 receptors, with lower affinity with Adrenergic Alpha2 and Serotonin SHT1A receptors. Quetiapin has negligible affinity for the Cholinergic Muscarinic or Benzodiazepin receptors.

pharmacokinetic

absorption

Quetiapin absorbs well and completely transformed after drinking. Birth is not significantly affected by food.

Distribution

quetiapin binds 83% to plasma protein.

Metabolism

Quetiapin is metabolized by the liver by CYP450 3A4, maximum molecular concentration in the stable state of metabolites with activity N - Desalkyl quetiapin is equal to 35% of this concentration of Quetiapin.

Elimination

The sale time of Quetiapin and N-Desalkyl Quetiapin is 7 hours and 12 hours respectively. Quetiapin and its metabolites eliminate through feces (20%), through urine (73%).

Before taking Queitoz-50 Davipharm Treatment of schizophrenia, bipolar disorder (3 blisters x 10 tablets)

How to use

queitoz pills are used orally.

Dosage

Treatment of schizophrenia:

should take Quetiapin twice a day, during or outside the meal. Depending on the clinical response and tolerance of each patient, the dose can be adjusted in the range of 150 to 750 mg/day.

should take Quetiapin 2 times a day, during or outside the meal. Should exceed 200 mg/day. The dose can be adjusted depending on the clinical response and tolerance of each patient, between 200 to 800 mg/day. The usual dosage has a treatment effect of 400 - 800 mg/day.

Elderly:

Like other anti -psychotic drugs, should be cautious when using Quetiapin in the elderly, especially in the beginning of the use of the drug. Should increase the dose every day, each level of 25 to 50 mg, to the dose to achieve the effect of maintenance, often lower than the dose to effectively treat in young patients.

Children and minors:

Safety and effectiveness of Quetiapin for children and young children have not been evaluated.

Patients with liver and kidney failure:

The oral quetiapin clearance decreases by about 25% in patients with liver or renal failure. Patients with liver or renal failure should start with quetiapin 25 mg/day. The daily dose should be increased, each level of 25 to 50 mg, to the dose to achieve effective treatment. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Recorded death in a clinical trial after an overdose of 13.6 g quetiapin (not in combination with other drugs). After bringing the drug to the market, in case of reporting the overdose of Quetiapin (non -coordinating drugs) death or coma is very rare. Patients who have suffered from severe cardiovascular disease may increase the risk of overdose.

In general, the signs and symptoms are due to increased pharmacological impact of the drug, such as vaginal, sedative, fast heart rate and hypotension, no specific detoxification for Quetiapine.

In case of severe poisoning, it is necessary to consider the ability due to the effects of many drugs, take special care measures, including setting and maintaining airway, ensuring ventilation and adequate oxygen supply, monitoring and cardiovascular support. Need to continue monitoring and monitoring patients closely until complete recovery.

What to do when forgetting 1 dose?

Not recorded.

Side Effects

When using queitoz pills , you may experience unwanted effects (ADR).

Very common (ADR> 10%)

Nervous system dysfunction: dizziness, dizziness, drowsiness.

Common, ADR> 1/100

Nervous system dysfunction: fainting.

Respiratory, chest and medical disorders: rhinitis.

Disorders of blood system and lymph: leukopenia.

Heart dysfunction: tachycardia.

Vascular dysfunction: Hypotenia Hematoma .

Disorders of the digestive system: dry mouth, constipation, difficulty urinating.

Side effects on the spot and whole body: mild weakness, peripheral edema. Subclinical: weight gain, serum transaminase (ALT, AST).

Neutral leukopenia.

Blood sugar increases to the level of pathology.

Uncommon, 1/1000

Bloody and lymphatic dysfunction: Multi -kind white blood cells.

Immune system dysfunction: Hypersensitivity.

Clinical: increasing gamma - GT4, increasing serum triglycerides at any time, increasing total cholesterol (mainly LDL - C).

Nervous system dysfunction: convulsions, tremor syndrome.

Rare (0.01%

Side effects on the spot and the whole body: malignant syndrome due to sedatives.

Genital dysfunction: erectile dysfunction.

Very rare (ARD

Immune system disorders: Anaphylactic reaction.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

quuritoz 50 mg contraindicated in the following cases:

Hypersensitivity to any drug of the drug.

Precautions when using

neutropenia

Heavy neutropenia (

Risk factors that can cause leukopenia include: Previous low leukocytes, a history of neutropenia due to drug use. Stop using Quetiapin when a patient has neutrophils

Hyperglycemia and pathological hyperglycemia

Having acknowledged blood glucose in patients using Quetiapin although the relationship has not been set. Patients at risk of diabetes need to be monitored possible plays.

Cardiovascular disease

Quetiapin should be used cautiously for patients who already know if they have cardiovascular disease, cerebrovascular disease, or other pathological conditions that can cause hypotension.

Quetapin can cause vertical hypotension, especially in the first stage of dose adjustment; Often occurs in older patients.

In clinical trials, Quetiapin is not related to an increase in QT. However, like other anti -psychotic drugs, should be cautious when prescribing Quetiapin simultaneously with the known drugs that extend the QT range, especially in the elderly patients.

convulsions

In control clinical trials, there is no difference in the frequency of epilepsy between the group of patients using Quetiapin and the fake group.

Like other anti -psychotic drugs, should be cautious when using the drug for patients with a history of epilepsy. Late arbitrary movement disorders: Like other anti -psychotic drugs, Quetiapin can cause late movement disorders during prolonged treatment.

When there are any signs or symptoms, late movement disorders, should consider reducing the dose or stopping quetiapin.

Sedative syndrome

Malignant syndrome caused by neuroleptic is related to the treatment of anti -psychotic drugs, including Quetiapin.

Clinical manifestations include overcrowding, mental changes, muscle spasms, unstable autonomous nervous systems and increased creatin phosphokinase. In this case, Quetiapin should be discontinued and appropriate treatment.

Reaction due to sudden stopping drugs

Symptoms of nausea, vomiting and insomnia are rare when suddenly stopping anti -psychotic drugs.

Relapses of mental symptoms can also occur, and the appearance of unintentional movement disorders (such as not sitting still, muscular disorders and movement disorders) have been recorded. So stop the drug slowly.

Elderly patients with intellectual decline

Quetiapin has not been ratified to treat patients with mental disorders related to dementia.

In a synthetic analysis (meta - analysis) for non -typical anti -psychotic drugs, there was a report on increased risk of death in elderly patients with psychotic disorders associated with dementia compared to placebo.

The ability to drive and operate machinery

quetiapin can cause drowsiness, patients need to be cautious when operating the machine and driving.

Pregnancy

Quetiapin's efficiency and safety for pregnant women has not been established. Therefore, Quetiapin should only be used during pregnancy when the benefits are out of the risks that may occur.

Breastfeeding period

is unknown to the extent of quetiapin into breast milk. Therefore, women should stop breastfeeding while using Quetiapin.

Medicinal interaction

Alcohol: Increased risk of drowsiness, hypotension.

CYP 3A4 enamel induction substances such as phenytoin, carbamazepine: Reducing the concentration of quetiapin in plasma.

CYP 3A4 enzyme inhibitors such as ketoconazol, erythromycin: Increasing quetiapin levels in plasma.

Storage

In a dry place, avoid light, the temperature does not exceed 30 ° C.

Other drugs

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