Rabaris 20mg Aristopharma treat gastroesophageal reflux disease (5 blisters x 10 tablets)

Dosage form Box of 5 blisters x 10 tablets
Specifications Rabeprazole

Ingredient

Composition information	Content
Rabeprazole	20mg

Uses

indications

Rabaris drugs are indicated in the following cases:

Treatment of gastroesophageal reflux disease (GERD) causes ulcers or corrosion: Rabeprazol is indicated for short -term treatment (4 to 8 weeks) to treat and reduce symptoms of gastroesophageal reflux disease (GERD) causing ulcers or corrosion. For patients who do not support after 8 weeks of treatment, one more treatment may be used with Rabeprazol 8 more weeks. Controlled studies have not been performed for more than 12 months. Most patients heal within 4 weeks. Patients who fail to treat, should perform sensitive tests. If resistance to clarithromycin or cannot be tested for sensitivity, should use other antibiotic therapy. Learning

Rabeprazole belongs to the anti -secret substance group (replacement benzimidazole proton pump inhibitors) does not manifest the characteristic antagonistic H2 h2 or acetylcholine secretion, but prevents gastric secretion by inhibiting H+/K+ ATPase stomach on the surface of the secretion of the stomach cells. Because this enzyme is considered as an acid pump (proton) in the wall of the wall, Rabeprazole is characterized as a stomach proton pump inhibitor. Rabeprazole prevents the final stage of gastric secretion. In stomach wall cells, Rabeprazole receives an additional proton, accumulated and transformed into an active sulfenamide.

Pharmacokinetics

absorption

The absolute biological comfort of the type of Rabeprazol tablet oral 20 mg (compared to the intravenous use) is approximately 52%. When Rabeprazol is used with a high -fat meal, TMAX is changed and can slow down the absorption for up to 4 hours or longer, however, CMAX and Rabeprazol's absorption level (AUC) change significantly. Therefore, Rabeprazol can be used without caring for meal time.

Distribution

rabeprazol binds to plasma proteins is 96.3%.

Metabolism

Rabeprazol is strongly metabolized. Thioether and sulphon are the main metabolites found in human plasma. These metabolites do not have significant antagonism activity. In vitro studies prove that Rabeprazol is metabolized in the liver mainly by Cytochrom P450 3A (CYP3A) into Sulphon and Cytochrom P450 2C19 (CYP2C19) into methyl reduction.

Elimination

After taking a single dose of 20 mg Rabeprazole has 14C radio isotope, about 90% of the drug is discharged into the urine, mainly thioether carboxylic acid; Its glucuronide and mercapturic acid metabolites. The rest is found in stool. The total radioactive activity found is 99.8%. Rabeprazole is not found in urine or in feces.

Before taking Rabaris 20mg Aristopharma treat gastroesophageal reflux disease (5 blisters x 10 tablets)

How to use

Take oral use.

Rabeprazol tablets should be swallowed. Do not chew, crush or break the pill. Rabeprazol tablets can be used with or not accompanied by food.

Dosage

Rabeprazol is recommended not for children, because there is no experience used in children.

Treatment of gastroesophageal reflux disease (GERD)

The recommended dose for adults is 20 mg of Rabeprazol, should be taken once a day in the morning, before eating about 4 to 8 weeks. For patients who do not help after 8 weeks of treatment, one more treatment can be used with Rabeprazol 8 more weeks.

Maintain after healing gastroesophageal reflux disease (GERD)

The recommended dose for adults is 20 mg Rabeprazol, should be taken once a day in the morning, before eating.

Treatment of gastroesophageal reflux disease (GERD) symptoms

recommended dose for adults is 20 mg Rabeprazol, should be taken once a day in the morning, about 4 weeks before eating. If the symptoms are not completely resolved after 4 weeks, one more treatment may be used.

Treatment of duodenal ulcer

The recommended dose for adults is 20 mg Rabeprazole, drink once a day after breakfast with a treatment for about 4 weeks. The majority of patients heal duodenum ulcers within 4 weeks. Some patients may need one more treatment to heal the ulcer.

Eliminate Helicobacter pylori to reduce the risk of duodenal ulcer.

Three drug therapy:

rabeprazole: 20 mg twice/day x 7 days.

Amoxicillin: 1000 mg twice/day x 7 days.

Rabeprazole dose for patients with increased diseases instead of individuals. The starting dose for adults recommends 60 mg once a day. The dose should be adjusted according to the needs of each patient and prolonged use according to clinical indications. Some patients may need to divide the dose. Can use the dose up to 100 mg once daily and 60mg twice daily.

It is not necessary to adjust the dose for the elderly, patients with kidney disease or mild to medium liver failure patients. Due to the lack of clinical data of Rabeprazole in patients with severe liver failure, it is cautious when taking the drug for these patients.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when overdose? There is no specific antidote for Rabeprazol. Rabeprazol is strongly linked to protein and is not easily separated. In case of overdose, symptomatic treatment and support.

The single doses of oral Rabeprazol 786 mg/kg and 1024 mg/kg are deadly to mice and large mice respectively. The single dose of 2000 mg/kg is not fatal to the dog. The main symptom of acute poisoning is to reduce activity, breathing, lying on your stomach or leaning on one side and convulsions occur in mice and large mice, diarrhea, tremor, convulsions and coma in dogs.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Rabaris, you may experience unwanted effects (ADR).

In the short -term and long -term studies, the following side effects regardless of the causes were reported in patients treated with Rabeprazole.

Body: weakness, fever, allergic reactions, chills, discomfort, chest pain under the breastbone, stiff neck, light sensitive reaction.

Cardiovascular system: high blood pressure, abnormal electrocardiogram, migraine, fainting, angina, suspense, slow heart sinus, tachycardia.

Digestive system: diarrhea, nausea, abdominal pain, vomiting, indigestion, flatulence, constipation, dry mouth, belching, gastritis, rectal hemorrhage, black bowel movement, anorexia, mouth ulcers, difficulty swallowing, gingivitis, cholecystitis, increased appetite, colonitis, esophagitis, tongitis, pancreatitis, rectal inflammation.

Endocrine system: hyperthyroidism, weak thyroid.

Blood and lymphatic system: Anemia, bruising, lymph nodes.

Metabolic and nutrition disorders: edema, weight gain, dehydration, weight loss.

Muscle system: muscle pain, arthritis, crushing legs, joint disease, chamber inflammation.

Nervous system: Insomnia, anxiety, dizziness, weakness, stress, drowsiness, tone of force, neurological pain, dizziness, convulsions, reduced sexual ability, neurological disease, abnormal, tremor.

Respiratory system: Difficulty breathing, asthma, nosebleeds, laryngitis.

Skin and appendages: rash, itching, sweating, urticaria, hair loss. Special senses: cataracts, vision loss, glaucoma, dry eyes, abnormal vision, tinnitus, otitis media.

The urinary system - Sex: cystitis, urination, menstruation, difficulty urinating, uterine hemorrhage, multi -urinary.

Testing values

The following changes in the test parameters have been reported as side effects: platelet abnormalities, albuminuria, creatinine phosphokinase increased, abnormal red blood cells, hyperchemical hyperglycemia, hyperactivity, hyperglycidation, hypokalemia, hyperlypes, leukemia, abnormal liver function tests, SGPT increased urine, abnormal urine.

Treatment in combination with amoxicillin and clarithromycin. In clinical trials for coordination treatment of rabeprazole amoxicillin and clarithromycin (RAC), no side effects are caused by the combination of drugs. There are no clinical significant tests due to drug coordination.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Rabeprazol drugs are contraindicated in the following cases:

Patients who know hypersensitivity to Rabeprazol, benzimidazol derivatives or any ingredients of the drug.

Caution when using

responding to symptoms when treating with Rabeprazol does not rule out the presence of malignant stomach tumors.

Interaction in rabeprazol's stability with Warfarin has not been fully assessed in patients. There have been several reports on Inr and prothrombin increase in patients treated and proton pump inhibitors with warfarin. Inronger and prothrombin time can lead to abnormal bleeding and even death. The patients treated at the same time inhibit the proton pump with warfarin, they need to monitor the increase of Inr and the prothrombin time.

The ability to drive and operate machinery

Based on the pharmacological and side effect characteristics, it is not sure that Rabaris can reduce driving and operate machinery. However, if awake is reduced due to drowsiness, avoid driving and operating complex machinery.

Pregnancy

There are no good and suitable studies for pregnant women. Because studies on animal reproduction do not always properly predict the response to humans, so contraindicated for pregnant women.

The period of breastfeeding

Due to many excreted drugs on breast milk, and due to the likelihood of side effects on infants to breastfeed from Rabeprazole, deciding whether to stop the drug or stop breastfeeding to consider the importance of the mother.

Drug interaction

Rabeprazol is metabolized by the P450 (CYP 450) metabolic enzyme. Studies on healthy subjects show that Rabeprazol has no clinical interactions with other drugs metabolized by CYP 450, such as Warfarin and Theophyllin with single dose, diazepam using single -vein injection dose, and phenytoin using single intravenous doses (for additional oral use).

Interaction in rabeprazol's stability with other drugs metabolized by this enzyme has not been studied in patients. There have been reports to increase Inr and prothrombin time in patients using proton pump inhibitors, including simultaneous use of rabeprazol and warfarin. Inronger increase and prothrombin time can lead to abnormal bleeding and death.

Rabeprazole inhibits continuous gastric secretion. The interaction may occur with substances that the absorption of the drug depends on the stomach pH due to the acid -secreting intensity of Rabeprazole. For example, in normal people, simultaneously rabeprazole 20 mg once a day reduces approximately 30% of the bioavailability of ketoconazole and increases the AUC and CMAX of Digoxin, respectively 19% and 29% respectively. Therefore, it is necessary to monitor patients when such drugs are used simultaneously with Rabeprazole.

Treatment for combination of three rabeprazole, amoxicillin and clarithromycin drugs increases the plasma concentrations of rabeprazole and 14 - hydroxyclarithromycin.

Storage

In a cool, dry place, avoid light, temperatures below 30 ° C.

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