Rabestad 20 Stella medicine for gastroesophageal reflux treatment (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Rabeprazole

Ingredient

Composition information	Content
Rabeprazole	20mg

Uses

indications

Rabestad 20 pills are indicated in the following cases:

Gastroesophageal reflux disease .

Gastrointestinal ulcer disease. Proton) does not show the activity of cholinergic resistance or h2 receptor antagonist, but prevent stomach acid secretion by inhibiting H+, K+ ATPASE at the secret surface of the border of the stomach.

Because this enzyme acts as an acid pump inside the border cell, Rabeprazole is considered a stomach proton pump inhibitor. Rabeprazole inhibits the final step of gastric acid secretion. In the border cells of the stomach, Rabeprazole is protonized, accumulated and transformed into a form of activity sulfenamid.

Dynamic pharmacokinetics

Rabeprazole's peak in plasma concentration is reached for about 3.5 hours after drinking. Oral bioavailability is about 52%, because there is the first metabolism through the liver, so the difference between the single dose and the dose is repeated. Rabeprazole binds 97% to plasma protein.

The drug is strongly metabolized through the liver by the Cytochrom P450 ISOENZYM CYP2C19 and CYP3A4 systems into Thiioether, the thioether carboxylic acid, sulfon and desmethylthioether. The metabolites are excreted mainly in the urine (about 90%) and the rest through the feces. Selling duration of plasma is about 1 hour, increasing to 2-3 times in the case of liver failure, 1.6 times in people who are slowly metabolized through CYP2C19 and an increase of 30% in the elderly.

Before taking Rabestad 20 Stella medicine for gastroesophageal reflux treatment (3 blisters x 10 tablets)

How to use

rabestad 20 is used by oral.

The drug is usually taken in the morning.

Dosage

Gastroesophageal reflux disease - Severe esophagus

The usual dose of Rabeprazole Sodium is 20 mg/day/day for 4-8 weeks. After that, continue treatment for 10 mg or 20 mg per day depending on the response of the patient.

Digestive ulcerative disease

20 mg/day for 4 - 8 weeks for duodenal ulcer and 6-12 weeks for stomach ulcers.

Zollinger syndrome - Ellison

Starting dose 60 mg/day/day, adjust the dose according to the patient's response. The dose may increase to 120 mg/day; When the daily dose is higher than 100 mg should be divided into 2 times.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Symptoms

There is no experience in the case of rabeprazole too high doses. The highest overdose has been reported 80 mg. There are no clinical signs or symptoms related to overdose.

Treatment

Detoxification for Rabeprazole is not known. Rabeprazole is strongly connected to protein and is not easily separated. In case of overdose, symptomatic treatment and support.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Rabestad 20 , you may experience unwanted effects (ADR).

The most unwanted effect with Rabeprazole and other proton inhibitors are headache, diarrhea and skin rash.

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Rabestad 20 drugs contraindicated in cases of hypersensitivity to rabeprazole, other benzimidazol derivatives (such as Esomeprazol, Lansoprazol, Omeprazol, Pantoprazol) or any other ingredient of the drug.

Caution when using

influence on the gastrointestinal tract

Symptoms that respond to Rabeprazole do not prevent potential stomach cancer.

The respiratory effect

Using proton pump inhibitors may increase the risk of expancing infection (such as community -suffering pneumonia).

Symptomatic and asymptomatic maggesi maggesi in patients using prolonged proton pump inhibitors (at least 3 months or most cases of drug use over 1 year).

On the patient, the long -term treatment has been treated with proton pump inhibitors, or on the patient who is taking simultaneously proton pump inhibitors with digoxin or those that can lower blood magnesia (such as diuretics), doctors should pay attention to testing serum magnesium levels before starting prescriptions with Proton pump inhibitors and subsequent check -ups.

Rabestad 20 contains Tartrazin Lake excipients that can cause allergic reactions.

The ability to drive and operate machinery

Based on the pharmacological characteristics and data on unwanted effects, not sure Rabeprazole will reduce driving capabilities or the ability to use machines. However, avoiding driving or operating complicated machinery because the drug causes drowsiness, reducing alertness.

Pregnancy

There is no complete and strict research on pregnant women. Because studies on animal reproduction do not always predict the response on humans, this drug should only be used for pregnant women when really necessary.

The period of breastfeeding

It is unclear whether Rabeprazole is excreted through breast milk or not. Stop breastfeeding or stopping medication because the drug is likely to be harmful to breastfed babies.

Interactive drug

Stomach dependent drugs

Ability to interact with pharmacokinetics; Increase or decrease the absorption of drugs when gastric pH increases (such as digoxin, ketoconazole). Should closely monitor while taking the drug simultaneously with rabeprazole.

Sucralfat

Simultaneous use of Lansoprazol or Omeprazol with sucralfat slows down the absorption and reduces the bioavailability of these proton pump inhibitors. Use proton pump inhibitors at least 30 minutes before using sucralfat.

warfarin

Proton pump inhibitors can inhibit the metabolism of warfarin. There is no important clinical interaction in the test of single dose, but there has been a report that increases the international standardization ratio (INR) and the time of prothrombin (PT) on patients to simultaneously use these drugs. Need to monitor Inr and PT while using with rabeprazole.

Tyeum of drugs

Due to the absence of studies on the correlation of the drug, not mixing this drug with other drugs.

Storage

Store in closed packaging, dry place, avoid moisture. The temperature does not exceed 30 ° C.

Other drugs

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