Ranixe United medicine to treat stomach ulcer, duodenum (5 blisters x 10 tablets)

Dosage form Box of 5 blisters x 10 tablets
Specifications Ranitidine, magnesium oxide, magnesium aluminometasilicate, magnesium aluminate hydrate

Ingredient

Composition information	Content
Ranitidine	31.5mg
Magnesium Oxide	50mg
Magnesium aluminometasilicate	125mg
Magnesium Aluminate Hydrate	100mg

Uses

Indications

Ranixere is indicated in the following cases:

Treatment of peptic ulcer, esophageal reflux disease

Zollinger - Ellison syndrome. This drug is capable of reducing 90% of gastric acid secreted after taking 1 dose of treatment, which quickly causes a peptic ulcer and prevent recurrence. Moreover, there is an important role in controlling Zollinger - Ellison syndrome and excessive gastric secretion.

Ranitidine inhibits competition with histamine in the H2 receptor of the cell, reduces the amount of gastric acid secreted day and night, even in food stimulated by food, insulin, amino acid, histamine, or pentagastrin.

Ranitidin has a stronger inhibiting gastric acid secretion than cimetidine from 3 to 13 times but the unwanted effect (ADR) is less.

Magnesi oxyd, aluminum oxyd (magnesi aluminosilicate and magnesi alumin hydrate) are acidic anti -acid factors that increase gastric pH, reducing acidic symptoms. The drug reduces the effects of pepsin enzymes, this effect is especially important in people with digestive ulcers.

The optimal pH of Pepsin activity is 1.5 - 2.5; Due to the anti -acid that increases the gastric pH above 4, the pepsin resolution is the lowest.

Anti -acid -containing magnesium drugs often combine with aluminum antacids to reduce aluminum constipation effects.

pharmacokinetics

ranitidin

Ranitidin's bioavailability is about 50%. Take oral, after 2-3 hours, the maximum concentration in plasma will achieve the highest. The absorption is almost no effects of food and antacids.

ranitidin is not much metabolized and does not interact with many drugs like cimetidine.

Ranitidin is excreted mainly through the renal tubules, the half -life is 2-3 hours, 60 - 70% of oral doses are discharged through the urine, the rest is discharged through feces.

Magnesi Oxide

Analysis of urine within the first 24 hours shows 35% of oral doses except for constant form.

Magnesi Oxyd reacts with hydrochloric acid to form magnesi chloride and water. About 15 - 30% of the Magnesi Chloride has just formed absorbed and then eliminated through urine in humans with normal kidney function. And the amount of Magnesi oxyde has not yet transformed into magnesium chloride can be transformed in the small intestine and is not significantly absorbed.

aluminum oxyd

Slowly dissolved aluminum oxide in the stomach and react with stomach hydrochloric acid to form aluminum chloride and water. About 17 - 30% of aluminum chloride forms absorbed and quickly excreted through the kidneys in people with normal renal function. In the small intestine, aluminum chloride forms aluminum aluminum insoluble, poorly absorbed and eliminated in the feces.

Before taking Ranixe United medicine to treat stomach ulcer, duodenum (5 blisters x 10 tablets)

How to use

Ranixere is taken orally.

Dosage

Adults (15 - 80 years old): The usual dose is 2 capsules/time, 3 times a day. The total dose per day should not exceed 5 drinks (10 tablets).

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms

Overdose can increase unwanted effects.

Handling

Stop taking medicine and consult a doctor or pharmacist.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Ranixere you can experience unwanted effects (ADR).

Uncommon, 1/1000

Allergic reactions: rash, erythema, itching and edema.

The whole body: may feel chest tightness, pale skin, cold hands and feet, cold sweat and stuffy nose. The rash, along with high body temperature, erythema, blisters due to fever can appear throughout the body, lips and mucosa, sore throat, fever, discomfort, face and inside the white eyelid, bleeding (in the gums and nose).

liver: jaundice.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Ranixe drug is contraindicated in the following cases:

sensitive to the ingredients of the drug.

Children under 15 years old and elderly people over 80 years old.

Pregnant and lactating women.

Patients are taking hemorrhage.

Caution when using

Antihistamine H2, which can cover the symptoms of stomach cancer, so it is necessary to eliminate the possibility of cancer before treatment with Ranile.

After 3 -day Ranixi use, if the symptoms are not improved, the medication should be stopped, or/or conduct appropriate treatment. Do not take the drug continuously for more than 2 weeks.

Do not drink alcohol while taking the drug.

In case of overdose, should stop taking the drug and/ or conduct appropriate treatment.

Should be cautious when using Ranixes in the following patients:

Patients being treated: immune system disorders, hematological system disorders, renal dysfunction, liver disorders, duodenal disorders, asthma and rheumatism.

Patients with a history of red blood cells, leukopenia and thrombocytopenia.

Patients with sore throat, cough and body temperature because the side effects of the drug can worsen the symptoms of the disease.

Patients are taking drugs: steroids, antibiotics, cancer and antifungal because sometimes leukopenia and platelets may occur.

Patients with severe liver failure, porphyrin metabolic disorders should be carefully monitored due to the risk of increased side effects and overdose.

Patients with a history of kidney dysfunction should consult a doctor or pharmacist.

The ability to drive and operate machinery

does not affect.

Pregnancy

Safety when using drugs in pregnant women has not been established, so it should not be used for pregnant women.

Breastfeeding period

Excreted drugs in breast milk, so do not use medication in breastfeeding women.

Drug interaction

The absorption of stomach antacids may be reduced due to the following drugs: Tetracyclin, antibiotics of the new generation quinolon group (such as ofloxacin, ...).

ranitidin reduces the absorption of ketoconazole, fluconazole and otraconazole. Do not use with other stomach and intestinal treatments.

Storage

Store at room temperature no more than 30 ° C.

Other drugs

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