Raxium 20 DHG medicine treats stomach ulcer, duodenum (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Rabeprazole

Ingredient

Composition information	Content
Rabeprazole	20mg

Uses

indications

Raxium 20 drugs are indicated in the following cases:

Treatment of active duodenal ulcer, benign stomach ulcers, gastroesophageal reflux disease - ulcerative or erosion form (GERD), Zollinger - Eleson syndrome and other conditions of increased diseases. Severe. Specialized enzyme H+/K+-Aatpase (acid pump or proton pump).

Effective proportional to dosage and inhibit both basic acid secretion and acid secretion due to stimulation regardless of stimuli. Because it is a weak base, Rabeprazole is quickly absorbed and focuses on the acidic environment of the wall. Rabeprazole is converted into a sulphenamide form that is active through protonization and then reacts with Cysteine available in the proton pump.

After taking a dose of 20 mg of sodium Rabeprazole, the onset of acid secretion effect occurs within an hour, with maximum efficiency between two and four hours. 23 hours after the first dosage Rabeprazole sodium, the basic acid secretion is 69% and the inhibition of acid secretion caused by food stimulating food is 82% and the inhibitor time lasts up to 48 hours. Rabeprazole's acid secretion effect is slightly increased when the daily dose is repeated, reaching stable inhibition after three days. When stopping the drug, normal acid secretion activity after 2–3 days.

Dynamic pharmacokinetics

Raxium 20 is a tablet in the intestine (insoluble in the stomach).

absorption:

Rabeprazole is absorbed quickly, the peak concentration in plasma is about 3.5 hours and bioavailing is about 52% after taking the dose of 20 mg. Rabeprazole's peak in the peak (CMAX) and AUC ratio with the dose of 10–40 mg. In addition, bioavailability does not increase with repeated dose. There is no clinical interaction with food. Food and time of medication during the day do not affect the absorption of the drug.

Distribution:

rabeprazole is heavily connected to plasma proteins (about 97%).

Metabolism:

Rabeprazole is metabolized through the liver's Cytochrome P450 system. In studies with human liver microsome shows that Rabeprazole sodium is metabolized by isenzyme CYP2C19 and CYP3A4. In these studies with different plasma levels, Rabeprazole does not touch nor inhibit CYP3A4.

Era:

In healthy people, the semi -cancellation time in plasma is about 1 hour (0.7–1.5 hours) and the body clearance is 283 ± 98 ml/min. About 90% of the dose is exported in the urine in the form of metabolism, the rest is excreted through feces.

Before taking Raxium 20 DHG medicine treats stomach ulcer, duodenum (3 blisters x 10 tablets)

How to use

oral medication. Should drink whole tablet, should not chew or crush the pill. Take medicine before breakfast or before going to bed.

Dosage

Adults/Elderly

Active duodenum ulcer:

Take 10 mg or 20 mg x 1 time/ day, for 4–8 weeks.

benign stomach ulcer activity:

Oral 10 mg or 20 mg x 1 time/day, for 6–12 weeks.

Gastroesophageal reflux disease - ulcerative or abrasive form (gerd):

Take 10 mg or 20 mg x 1 time/day, for 4–8 weeks.

Long -term maintenance treatment of gastroesophageal reflux disease:

Can use maintenance dose 10 mg or 20 mg x 1 time/day.

Treatment of symptoms of gastroesophageal reflux disease from average to very severe:

Take 10 mg x 1 time/day for patients without esophagitis. If symptoms do not improve after 4 weeks, patients need further examination.

Zollinger - Ellison syndrome and other pathological increased conditions:

The starting dose is 60 mg x 1 time/day. Can increase the dose up to 100 mg x 1 time/day or 60 mg x 2 times/day. Some patients with Zollinger - Elison syndrome have been treated continuously for a year.

Deduction Helicobacter pylori:

Seven -day combination treatments are proposed as follows: Raxium 20 x 2 times/day + Clarithromycin 500 mg x 2 times/day + Amoxicillin 1 g x 2 times/day.

Children

Children ≥ 12 years: Safe and effective in short -term treatment GERD (used for 8 weeks).

Children

Patients with kidney failure and liver failure

No dose adjustment.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Because the drug is heavily attached to plasma proteins, it is not easy to separate. Because there is no specific antidote, in case of overdose, patients need symptoms and supportive measures.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Raxium 20, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Infection and parasitic infection: infection.

central nervous system: insomnia, headache, dizziness.

Respiratory: cough, sore throat.

digestive: diarrhea, abdominal pain, nausea, flatulence.

Bone muscle: Non -specific pain/back pain.

Uncommon, 1/1000

Central nerve: Stress.

Respiratory: bronchitis, sinusitis. digestive: indigestion, dry mouth, belching.

muscle and skeletal: muscle pain, crust, joint pain, fracture.

kidney - Urinary: Urinary infection.

Rare, 1/10000

Blood: neutropenia, leukopenia, thrombocytopenia, white blood cells.

immune: allergies (face edema, hypotension and shortness of breath, erythema, water ball reaction and allergic reactions often disappear after stopping the drug). Metabolism: Anorexia.

Central nerve: depression. Eye: visual disorders. digestive: gastritis, stomatitis, taste disorders.

Kidney - Intellitis: interstitial nephritis.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Raxium 20 contraindicated drug in cases of sensitivity to any ingredients of the drug and benzimidazole derivatives.

Be cautious when using

improving symptoms through Rabeprazole treatment does not rule out the presence of stomach or esophagus, so it is necessary to eliminate the possibility of cancer before starting treatment.

Patients with long -term treatment (special treatment for more than a year) should be checked regularly.

Patients with severe liver dysfunction.

rabeprazole is not recommended for children because they have no experience using rabeprazole in this age group.

Rare Magnesi blood in patients treated with Proton pump inhibitors (PPI) for at least 3 months, may be more common in the case of 1 year of treatment. In most patients, treating blood magnesium by adding magnesi and stopping using PPI.

Proton pump inhibitors (PPI), especially if high doses and a long period of time (> 1 year), may be associated with an increase in the risk of osteoporosis associated with hip, wrist or spine fractures, mainly in the elderly or in the presence of other risk factors.

PPI treatment, including sodium Rabeprazole, can increase the risk of gastrointestinal infections such as Salmonella, Campylobacter and Clostridioides Difficile.

The ability to drive and operate machinery

The drug does not reduce the ability to drive or operate machinery. However, if sleepy, avoid driving or operating complex machinery.

Pregnancy

There is no complete or well -controlled research in pregnant women and experience after the drug is used on the market is limited. Only use Rabeprazole sodium in pregnant women when the potential benefits are better than the risk that may occur for the fetus.

The period of breastfeeding

It is unclear whether Rabeprazole sodium is excreted in milk or not and there is no research on breastfeeding women. However, Rabeprazole sodium has excretion in mouse milk. Therefore, rabeprazole should not be used in nursing women. If required to use Rabeprazole sodium, you should stop breastfeeding.

Drug interaction

rabeprazole inhibits the excretion of the acidic stomach, so the interaction with drugs can be absorbed depending on the pH.

Rabeprazole does not interact with liquid antacids.

Simultaneous use of rabeprazole with ketoconazole or iTraconazole may reduce antifungal concentration in plasma.

rabeprazole inhibits the metabolism of cyclosporin when used in combination.

Simultaneous use of rabeprazole and warfarin increases Inr and prothrombin time, which can lead to abnormal bleeding and death.

Do not use simultaneously with Atazanavir.

Storage

In a dry place, the temperature does not exceed 30 ° C, avoiding light.

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