Rebamipid 100 DHG medicine for gastric ulcer treatment (5 blisters x 10 tablets)

Dosage form Box of 5 blisters x 10 tablets
Specifications Rebamipide

Ingredient

Composition information	Content
Rebamipide	100mg

Uses

indications

Rebamipid 100 drugs are indicated in the following cases:

Stomach ulcer.

Preventive or healing effects in the stomach ulcer model

Rebamipid prevents the damage to gastric mucosa in different experimental ulcer models in mice, including ulcers created by stress when immersed in water, due to aspirin, indomethacin, histamine, serotonin and pyloric gasters. Rebamipid also protects the mucosa from damage caused by other ulcer conditions that may generate the reaction of oxygen roots, including blood re -provision for ischemic mucosa, use platelet activation factor (PAF) or Diethyldithocarbamate (DDC) and use indomethacin in stress.

In an ulcerative model produced by acetic acid in mice, Rebamipid promotes gastric ulcer and prevents ulcers recurrence after ulcer 120 - 140 days.

Preventive or healing effects in the gastritis model

Rebamipid prevents the growth of taurocholic acid (one of the main ingredients of bile acid) - causing mucositis and promoting healing of mucositis in combination with experimental mice.

The effect of increasing prostaglandin

Rebamipid increases the formation of prostaglandin E2 (PGE2), in the gastric mucosa in the mouse.

The drug also increases the content (PGE2), i5 - keto - 13, 14 - dihydro - Peg2 (is a metabolic substance of PGE2), and Prostaglandin 12 (PGI2) in gastric juice.

Cell protection effect

Rebamipid has the effect of protecting stomach cells, inhibiting mucosal damage caused by ethanol, strong acid or strong base in mice. In healthy men, the drug prevents the damage to the gastric mucosa caused by the use of aspirin, ethanol or HCl - ethanol.

The effect of increasing mucus

Rebamipid promotes the activity of gastric enzymes synthesizing glycoprotein with high molecular weight, thickening the mucus layer on the surface of the stomach lining and increasing the amount of mucus dissolved in the stomach in the mouse.

The effect of increasing blood flow into the mucosa

Rebamipid increases blood flow to the gastric mucosa and improves hemodynamic impaired after mouse loss.

In addition, Rebamipid also works on the fence of the mucosa, the secretion of the stomach, the number of cells of the mucosa, the recovery of the stomach lining, the effect on the oxidative roots, the infection of the inflammatory cell in the gastric mucosa, the cytokin release (Interleukin - 8) causing inflammation in the gastric mucosa. pharmacokinetics

Rebamipid pharmacokinetics parameters in plasma:

216 ± 79 1.9 ± 0.7

874 ± 209

Rebamipid absorption speed tends to be slow when used orally at a dose of 150 mg for 6 healthy people after a meal compared to the absorption rate if taken before eating. However, food does not affect the bioavailability of the drug in humans.

Mobile parameters are recorded from patients with renal failure after taking a single dose of 100 mg of Rebamipid shows higher plasma concentrations and longer half -life than in healthy people. In a stable state, Rebamipid concentration in mental hemorrhage is observed in patients with renal fertilizer after the dose is repeated very similar to the values when using a single dose. Therefore, the drug is considered not accumulated.

metabolism: After giving healthy adult men with a dose of 600 mg, Rebamipid is mainly excreted in urine in the form of constant drugs. A metabolite has a group of hydroxyl in the 8th place that has been found in the urine. However, this metabolic secretion is only 0.03% of the dose used. The enzyme related to this metabolic formation is Cytochrom P450 3A4 (CYP3A4).

Elimination: When healthy men use a single dose of Rebamipid 100 mg, about 10% of the doses are excreted in the urine.

linked to protein: Rebamipid at the dose of 0.05 - 0.5 mcg/ml was put into a vitro -eating plasma and 98.4% - 98.6% of this drug has been linked to plasma proteins.

Before taking Rebamipid 100 DHG medicine for gastric ulcer treatment (5 blisters x 10 tablets)

How to use

oral tablets. Take the tablet with a glass of water.

Dosage

Stomach ulcer and treat stomach mucosa lesions: Take 100 mg x 3 times/day.

or as directed by the physician.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? Symptomatic treatment should be treated.

In case of emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double doses to compensate for missed dose.

Side Effects

When using Rebamipid 100 you may experience unwanted effects (ADR):

Clinical undesirable effects:

shock and anaphylactic reaction (unknown rate*): shock and anaphylactic reaction may occur. Need to monitor patients closely. If there are abnormal signs, stop taking the drug and take appropriate treatments. Need to monitor patients closely. If there are abnormal signs, stop taking the drug and take appropriate treatments. Need to monitor patients closely. If there are signs of abnormalities through testing, stop taking the drug and take appropriate treatments.

Frequency

Hypersensitivity: rash, itching, eczema is like a rash due to drugs, other sensitive symptoms. If there are symptoms, it is necessary to stop taking the drug. If the transaminase level increases significantly or has fever and rash, it is necessary to stop taking the drug and take appropriate treatments.

Hypersensitivity: urticaria. If there is symptoms, medication must be stopped. If the transaminase level increases significantly or has fever and rash, it is necessary to stop taking the drug and take appropriate treatments. Clearly the rate of occurrence of side effects has been reported voluntarily.

Instructions on how to handle ADR:

Notify the physician with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Rebamipid 100 contraindications in the following cases:

Patients with a history of hypersensitivity to any ingredients of the drug.

Be cautious when using

need to be very careful when taking the drug for patients in the following cases:

Used for the elderly: Pay attention to the elderly patients to minimize the risk of stomach -intestine disorders, because physiological, elderly patients are often more sensitive to this drug compared to young patients.

The effect of the drug on the ability to drive and operate machinery

Caution for those who are operating machinery, driving train, people who are working on high and other cases because the drug is likely to cause dizziness or drowsiness in some patients.

Use drugs for women during pregnancy and lactation

Rebamipid should only be used for pregnant women or likely to be pregnant if the benefits of treatment are higher than any possible risk. (Not yet determined safety for pregnant women).

Women who are breastfeeding must stop breastfeeding before using Rebamipid (mice studies show that rebamipid is excreted in milk).

Interactive drug

no drug interactions have been recorded.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

To be out of reach of children, read the user manual carefully before use.

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